FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135770420> ?p ?o ?g. }

• W2135770420 abstract "OF DISSERTATION PRECLINICAL EVALUATION OF LOBELINE FOR THE TREATMENT OF ADHD: COMPARISON WITH PSYCHOSTIMULANT THERAPIES This dissertation work investigated the effect of acute and repeated in vivo administration of lobeline on dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) function. The effects of lobeline were then compared to the effects of acute and repeated in vivo administration of methylphenidate and amphetamine to determine if lobeline produced similar effects compared to these Attention Deficit Hyperactivity Disorder (ADHD) medications. These medications are considered the first line of pharmacotherapy for ADHD, although there is a growing concern associated with their potential for abuse and other side effects. This merits the need for novel ADHD treatments that have a safer side effect profile. If lobeline alters DAT and VMAT2 function in the same way as methylphenidate or amphetamine, further investigation may be necessary to evaluate lobeline as a potential treatment for ADHD. Kinetic analysis of [H]dopamine (DA) was utilized to determine the effect on DAT and VMAT2 function in rat striatum. Results from the DAT experiments, revealed that lobeline as well as amphetamine had no effect on DAT function. However, methylphenidate increased DAT function after acute and 7-day treatment. None of the drug treatment regimens altered Km. To determine if the methylphenidateinduced increase in DAT function was due to DAT trafficking, biotinylation and Western blot analyses were performed. Acute administration of methylphenidate did not alter surface DAT, however repeated administration of methylphenidate for 7 days decreased intracellular DAT, suggesting that methylphenidate redistributes DAT in a time-dependent manner. Similar results were found in the VMAT2 experiments. Lobeline and amphetamine had no effect on VMAT2 function after acute or repeated administration. Amphetamine decreased the Km after repeated administration for 7 days. Methylphenidate increased VMAT2 function after acute and repeated administration for 7 days. The overall results of these experiments suggest that methylphenidate interacts with DAT and VMAT2 in a different manner than amphetamine and lobeline. In addition, since lobeline and amphetamine had no effect on DAT and VMAT2 function, further investigation is warranted to elucidate the underlying mechanisms of the therapeutic actions of these agents. This additional information will aid in the development of novel treatments for ADHD." @default.
• W2135770420 created "2016-06-24" @default.
• W2135770420 creator A5021307927 @default.
• W2135770420 date "2011-01-01" @default.
• W2135770420 modified "2023-09-26" @default.
• W2135770420 title "PRECLINICAL EVALUATION OF LOBELINE FOR THE TREATMENT OF ADHD: COMPARISON WITH PSYCHOSTIMULANT THERAPIES" @default.
• W2135770420 cites W10325908 @default.
• W2135770420 cites W1220222425 @default.
• W2135770420 cites W126854689 @default.
• W2135770420 cites W1515432410 @default.
• W2135770420 cites W1524110814 @default.
• W2135770420 cites W1526660810 @default.
• W2135770420 cites W1540614120 @default.
• W2135770420 cites W1542676884 @default.
• W2135770420 cites W1573516548 @default.
• W2135770420 cites W1598364670 @default.
• W2135770420 cites W1599299698 @default.
• W2135770420 cites W1604223290 @default.
• W2135770420 cites W1608908265 @default.
• W2135770420 cites W1696280731 @default.
• W2135770420 cites W169965504 @default.
• W2135770420 cites W1730181129 @default.
• W2135770420 cites W1783100747 @default.
• W2135770420 cites W1788048136 @default.
• W2135770420 cites W1797048281 @default.
• W2135770420 cites W18110794 @default.
• W2135770420 cites W1841443779 @default.
• W2135770420 cites W1851407835 @default.
• W2135770420 cites W1860158865 @default.
• W2135770420 cites W1885238897 @default.
• W2135770420 cites W1893908934 @default.
• W2135770420 cites W1895466054 @default.
• W2135770420 cites W1908021040 @default.
• W2135770420 cites W1921401097 @default.
• W2135770420 cites W1923591030 @default.
• W2135770420 cites W1928314647 @default.
• W2135770420 cites W1953561962 @default.
• W2135770420 cites W1956683302 @default.
• W2135770420 cites W1959337655 @default.
• W2135770420 cites W1963735974 @default.
• W2135770420 cites W1964130862 @default.
• W2135770420 cites W1964447578 @default.
• W2135770420 cites W1964520262 @default.
• W2135770420 cites W1964767493 @default.
• W2135770420 cites W1965620134 @default.
• W2135770420 cites W1966033474 @default.
• W2135770420 cites W1966099771 @default.
• W2135770420 cites W1966663884 @default.
• W2135770420 cites W1967188271 @default.
• W2135770420 cites W1967521605 @default.
• W2135770420 cites W1968490092 @default.
• W2135770420 cites W1968571803 @default.
• W2135770420 cites W1968611472 @default.
• W2135770420 cites W1969139870 @default.
• W2135770420 cites W1969378954 @default.
• W2135770420 cites W1969948765 @default.
• W2135770420 cites W1970031540 @default.
• W2135770420 cites W1970624418 @default.
• W2135770420 cites W1971635815 @default.
• W2135770420 cites W1971751319 @default.
• W2135770420 cites W1971869239 @default.
• W2135770420 cites W1972116107 @default.
• W2135770420 cites W1972571048 @default.
• W2135770420 cites W1972639908 @default.
• W2135770420 cites W1972943445 @default.
• W2135770420 cites W1973058343 @default.
• W2135770420 cites W1973178390 @default.
• W2135770420 cites W1973506599 @default.
• W2135770420 cites W1973514020 @default.
• W2135770420 cites W1973678939 @default.
• W2135770420 cites W1974211383 @default.
• W2135770420 cites W1974651690 @default.
• W2135770420 cites W1975066872 @default.
• W2135770420 cites W1975617196 @default.
• W2135770420 cites W1975977959 @default.
• W2135770420 cites W1976063687 @default.
• W2135770420 cites W1976660789 @default.
• W2135770420 cites W1976789367 @default.
• W2135770420 cites W1976924053 @default.
• W2135770420 cites W1977049293 @default.
• W2135770420 cites W1977634040 @default.
• W2135770420 cites W1978427046 @default.
• W2135770420 cites W1978755811 @default.
• W2135770420 cites W1979665818 @default.
• W2135770420 cites W1979816765 @default.
• W2135770420 cites W1980253852 @default.
• W2135770420 cites W1980428287 @default.
• W2135770420 cites W1980789028 @default.
• W2135770420 cites W1980851905 @default.
• W2135770420 cites W1981291913 @default.
• W2135770420 cites W1982292219 @default.
• W2135770420 cites W1982786179 @default.
• W2135770420 cites W1983427473 @default.
• W2135770420 cites W1984350563 @default.
• W2135770420 cites W1985127286 @default.
• W2135770420 cites W1985407755 @default.
• W2135770420 cites W1985645068 @default.
• W2135770420 cites W1985833159 @default.
• W2135770420 cites W1986839938 @default.
• W2135770420 cites W1987164572 @default.

• next