Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135773086> ?p ?o ?g. }
- W2135773086 endingPage "3268" @default.
- W2135773086 startingPage "3255" @default.
- W2135773086 abstract "SUMMARY There is broad interest in whether there is a tradeoff between energy metabolism and immune function, and how stress affects immune function. Under hypoxic stress, maximal aerobic metabolism is limited, and other aspects of energy metabolism of animals may be altered as well. Although acute hypoxia appears to enhance certain immune responses, the effects of chronic hypoxia on immune function are largely unstudied. We tested: (1) whether chronic hypoxia affects immune function and (2) whether hypoxia affects the metabolic cost of immune function. First, flow cytometry was used to monitor the peripheral blood immunophenotype of mice over the course of 36 days of hypoxic exposure. Second, hypoxic and normoxic mice were subjected to an adaptive immune challenge via keyhole limpet hemocyanin (KLH) or to an innate immune challenge via lipopolysaccharide (LPS). The resting metabolic rates of mice in all immune challenge treatments were also measured. Although hypoxia had little effect on the peripheral blood immunophenotype, hypoxic mice challenged with KLH or LPS had enhanced immunological responses in the form of higher antibody titers or increased TNF-α production, respectively. Initially, mice exposed to hypoxia had lower metabolic rates, but this response was transitory and resting metabolic rates were normal by the end of the experiment. There was no effect of either immune challenge on resting metabolic rate, suggesting that mounting either the acute phase response or a humoral response is not as energetically expensive as previously thought. In addition, our results suggest that immune responses to chronic and acute hypoxia are concordant. Both forms of hypoxia appear to stimulate both innate and adaptive immune responses." @default.
- W2135773086 created "2016-06-24" @default.
- W2135773086 creator A5038235980 @default.
- W2135773086 creator A5073659414 @default.
- W2135773086 creator A5082733015 @default.
- W2135773086 date "2011-10-01" @default.
- W2135773086 modified "2023-10-14" @default.
- W2135773086 title "Chronic hypoxia stimulates an enhanced response to immune challenge without evidence of an energetic tradeoff" @default.
- W2135773086 cites W1485236527 @default.
- W2135773086 cites W1485908957 @default.
- W2135773086 cites W1503667331 @default.
- W2135773086 cites W1515667338 @default.
- W2135773086 cites W1515730558 @default.
- W2135773086 cites W1518835034 @default.
- W2135773086 cites W1529749053 @default.
- W2135773086 cites W1667711738 @default.
- W2135773086 cites W1848530711 @default.
- W2135773086 cites W1943493722 @default.
- W2135773086 cites W1967636379 @default.
- W2135773086 cites W1968568784 @default.
- W2135773086 cites W1970955733 @default.
- W2135773086 cites W1973720695 @default.
- W2135773086 cites W1975059243 @default.
- W2135773086 cites W1980188755 @default.
- W2135773086 cites W1983057302 @default.
- W2135773086 cites W1985129279 @default.
- W2135773086 cites W1986411624 @default.
- W2135773086 cites W1987635937 @default.
- W2135773086 cites W1990655979 @default.
- W2135773086 cites W1995837138 @default.
- W2135773086 cites W1996490949 @default.
- W2135773086 cites W1997804122 @default.
- W2135773086 cites W1997871862 @default.
- W2135773086 cites W2009286881 @default.
- W2135773086 cites W2015585461 @default.
- W2135773086 cites W2016168742 @default.
- W2135773086 cites W2019403900 @default.
- W2135773086 cites W2020277250 @default.
- W2135773086 cites W2033283725 @default.
- W2135773086 cites W2036075321 @default.
- W2135773086 cites W2040439781 @default.
- W2135773086 cites W2040836184 @default.
- W2135773086 cites W2042079933 @default.
- W2135773086 cites W2043693307 @default.
- W2135773086 cites W2045922822 @default.
- W2135773086 cites W2046348353 @default.
- W2135773086 cites W2046800112 @default.
- W2135773086 cites W2049135436 @default.
- W2135773086 cites W2051558840 @default.
- W2135773086 cites W2052088896 @default.
- W2135773086 cites W2052197960 @default.
- W2135773086 cites W2054572171 @default.
- W2135773086 cites W2056126702 @default.
- W2135773086 cites W2062382041 @default.
- W2135773086 cites W2064011462 @default.
- W2135773086 cites W2064470478 @default.
- W2135773086 cites W2067948812 @default.
- W2135773086 cites W2068717659 @default.
- W2135773086 cites W2069974084 @default.
- W2135773086 cites W2070427308 @default.
- W2135773086 cites W2074571279 @default.
- W2135773086 cites W2076422538 @default.
- W2135773086 cites W2078273868 @default.
- W2135773086 cites W2082147778 @default.
- W2135773086 cites W2084019555 @default.
- W2135773086 cites W2089582877 @default.
- W2135773086 cites W2089916504 @default.
- W2135773086 cites W2091041420 @default.
- W2135773086 cites W2093600287 @default.
- W2135773086 cites W2093765191 @default.
- W2135773086 cites W2095800957 @default.
- W2135773086 cites W2099555137 @default.
- W2135773086 cites W2100567314 @default.
- W2135773086 cites W2103154710 @default.
- W2135773086 cites W2108435172 @default.
- W2135773086 cites W2109945035 @default.
- W2135773086 cites W2110785824 @default.
- W2135773086 cites W2111808595 @default.
- W2135773086 cites W2113535316 @default.
- W2135773086 cites W2114337266 @default.
- W2135773086 cites W2115219337 @default.
- W2135773086 cites W2116342174 @default.
- W2135773086 cites W2116993043 @default.
- W2135773086 cites W2119129835 @default.
- W2135773086 cites W2122339994 @default.
- W2135773086 cites W2123195960 @default.
- W2135773086 cites W2124566878 @default.
- W2135773086 cites W2127299418 @default.
- W2135773086 cites W2130133091 @default.
- W2135773086 cites W2131240705 @default.
- W2135773086 cites W2132203965 @default.
- W2135773086 cites W2135821619 @default.
- W2135773086 cites W2136016793 @default.
- W2135773086 cites W2139576132 @default.
- W2135773086 cites W2139879194 @default.
- W2135773086 cites W2143343444 @default.
- W2135773086 cites W2146335178 @default.
- W2135773086 cites W2147967849 @default.