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- W2135774865 abstract "Licht RW. Limits of the applicability and generalizability of drug trials in mania. Bipolar Disord 2002: 4(Suppl. 1): 66–68. ©Blackwell Munksgaard, 2002 During recent years, the majority of drug trials in mania have been conducted for the purpose of drug approval. On this background, this paper addresses to what extent these trials may actually provide the practising clinician with useful information. One major point is that selection prior to the point of randomization in RCTs in mania may limit the applicability of study results to patients seen in ordinary clinical practice. Limitations in study credibility and study design are also discussed. The need for large scale pragmatic studies using broad inclusion criteria, comparing the various treatments, alone or in combination, is emphasized." @default.
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- W2135774865 date "2002-09-01" @default.
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- W2135774865 title "Limits of the applicability and generalizability of drug trials in mania" @default.
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- W2135774865 doi "https://doi.org/10.1034/j.1399-5618.4.s1.27.x" @default.
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