Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135776750> ?p ?o ?g. }
- W2135776750 endingPage "397" @default.
- W2135776750 startingPage "387" @default.
- W2135776750 abstract "Initial sensitivity and tolerance development to the sedative-hypnotic and hypothermic effects of ethanol were investigated in gamma-protein kinase C (PKC) null mutant mice. Null mutants from a C57BL/6J x 129/SvJ mixed genetic background demonstrated decreased ethanol sensitivity and failed to develop chronic tolerance after 10 days of ethanol liquid diet. However, when the null mutation was introgressed onto a C57BL/6J background for six generations, the no tolerance phenotype for sedative-hypnotic and hypothermic effects of ethanol was no longer apparent Outcrossing the gamma-PKC null mutation to a C57BL/6J x 129/SvEvTac mixed background restored the no tolerance phenotype to ethanol-induced sedation after chronic ethanol diet; however, as measured by hypothermia, tolerance was still evident in the null mutant mice. These observations and the results of tests of chronic tolerance in the C57BL/6J, 129/SvJ, and 129/SvEvTac background inbred strains indicate that gamma-PKC plays an important role in initial sensitivity and tolerance to ethanol. However, the impact of gamma-PKC is modulated by the background genotype. These results stress the importance of including the effect of genetic background when evaluating the effects of single gene mutations on quantitative behavioral traits." @default.
- W2135776750 created "2016-06-24" @default.
- W2135776750 creator A5000917351 @default.
- W2135776750 creator A5007680291 @default.
- W2135776750 creator A5038557565 @default.
- W2135776750 creator A5050300076 @default.
- W2135776750 creator A5063726191 @default.
- W2135776750 creator A5081023159 @default.
- W2135776750 date "1999-03-01" @default.
- W2135776750 modified "2023-10-13" @default.
- W2135776750 title "Decreased Ethanol Sensitivity and Tolerance Development in gamma-Protein Kinase C Null Mutant Mice Is Dependent on Genetic Background" @default.
- W2135776750 cites W1522904635 @default.
- W2135776750 cites W1808628558 @default.
- W2135776750 cites W1964255834 @default.
- W2135776750 cites W1972677665 @default.
- W2135776750 cites W1975660197 @default.
- W2135776750 cites W1977966461 @default.
- W2135776750 cites W1981848263 @default.
- W2135776750 cites W1982832718 @default.
- W2135776750 cites W1994716095 @default.
- W2135776750 cites W1997278612 @default.
- W2135776750 cites W2011429118 @default.
- W2135776750 cites W2011627006 @default.
- W2135776750 cites W2012549768 @default.
- W2135776750 cites W2020869636 @default.
- W2135776750 cites W2021620079 @default.
- W2135776750 cites W2025758377 @default.
- W2135776750 cites W2034263343 @default.
- W2135776750 cites W2037512229 @default.
- W2135776750 cites W2041465378 @default.
- W2135776750 cites W2048705995 @default.
- W2135776750 cites W2058807117 @default.
- W2135776750 cites W2058851412 @default.
- W2135776750 cites W2059124791 @default.
- W2135776750 cites W2065309285 @default.
- W2135776750 cites W2067376187 @default.
- W2135776750 cites W2070660603 @default.
- W2135776750 cites W2071809577 @default.
- W2135776750 cites W2072029956 @default.
- W2135776750 cites W2072614922 @default.
- W2135776750 cites W2078793904 @default.
- W2135776750 cites W2085413817 @default.
- W2135776750 cites W2089032128 @default.
- W2135776750 cites W2090100880 @default.
- W2135776750 cites W2094194370 @default.
- W2135776750 cites W2114058218 @default.
- W2135776750 cites W2118774378 @default.
- W2135776750 cites W2119479764 @default.
- W2135776750 cites W2121504378 @default.
- W2135776750 cites W2142349181 @default.
- W2135776750 cites W2145417324 @default.
- W2135776750 cites W2151880786 @default.
- W2135776750 cites W2160614601 @default.
- W2135776750 cites W2161339778 @default.
- W2135776750 cites W2164124162 @default.
- W2135776750 cites W2167289000 @default.
- W2135776750 cites W2181518245 @default.
- W2135776750 doi "https://doi.org/10.1111/j.1530-0277.1999.tb04127.x" @default.
- W2135776750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10195808" @default.
- W2135776750 hasPublicationYear "1999" @default.
- W2135776750 type Work @default.
- W2135776750 sameAs 2135776750 @default.
- W2135776750 citedByCount "90" @default.
- W2135776750 countsByYear W21357767502012 @default.
- W2135776750 countsByYear W21357767502013 @default.
- W2135776750 countsByYear W21357767502015 @default.
- W2135776750 countsByYear W21357767502017 @default.
- W2135776750 countsByYear W21357767502018 @default.
- W2135776750 countsByYear W21357767502021 @default.
- W2135776750 countsByYear W21357767502023 @default.
- W2135776750 crossrefType "journal-article" @default.
- W2135776750 hasAuthorship W2135776750A5000917351 @default.
- W2135776750 hasAuthorship W2135776750A5007680291 @default.
- W2135776750 hasAuthorship W2135776750A5038557565 @default.
- W2135776750 hasAuthorship W2135776750A5050300076 @default.
- W2135776750 hasAuthorship W2135776750A5063726191 @default.
- W2135776750 hasAuthorship W2135776750A5081023159 @default.
- W2135776750 hasConcept C104317684 @default.
- W2135776750 hasConcept C126322002 @default.
- W2135776750 hasConcept C143065580 @default.
- W2135776750 hasConcept C153911025 @default.
- W2135776750 hasConcept C184235292 @default.
- W2135776750 hasConcept C195794163 @default.
- W2135776750 hasConcept C2779985140 @default.
- W2135776750 hasConcept C2780161600 @default.
- W2135776750 hasConcept C501734568 @default.
- W2135776750 hasConcept C54355233 @default.
- W2135776750 hasConcept C55493867 @default.
- W2135776750 hasConcept C57708383 @default.
- W2135776750 hasConcept C71924100 @default.
- W2135776750 hasConcept C86803240 @default.
- W2135776750 hasConcept C98274493 @default.
- W2135776750 hasConceptScore W2135776750C104317684 @default.
- W2135776750 hasConceptScore W2135776750C126322002 @default.
- W2135776750 hasConceptScore W2135776750C143065580 @default.
- W2135776750 hasConceptScore W2135776750C153911025 @default.
- W2135776750 hasConceptScore W2135776750C184235292 @default.
- W2135776750 hasConceptScore W2135776750C195794163 @default.