FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135781036> ?p ?o ?g. }

• W2135781036 endingPage "9755" @default.
• W2135781036 startingPage "9741" @default.
• W2135781036 abstract "Viral phenotype, tropism, coreceptor usage, and envelope gene diversity were examined in blood isolates collected from 27 individuals at different stages of human immunodeficiency virus type 1 (HIV-1) disease and tissue derived isolates from 10 individuals with AIDS. The majority (89%) of blood and all tissue HIV-1 isolates from all stages of infection were non-syncytium inducing and macrophage (M) tropic. Tropism and productive infection by HIV isolates in both monocytes and monocyte-derived macrophages (MDM) increased in advanced disease (HIV tropism for monocytes, 1 of 6 from categories I and II versus 11 of 21 [P = 0.05] from category IV and II [CD4 < 250]; and high-level replication in MDM, 1 of 6 from categories I and II versus 16 of 21 from categories IV and II [P = 0. 015]). There was a high level of replication of blood and tissue isolates in T lymphocytes without restriction at any stage. Overall, the level of replication in MDM was 5- to 10-fold greater than in monocytes, with restriction in the latter occurring mainly at entry and later stages of replication. Only three blood isolates were identified as syncytium inducing, and all had a dualtropic phenotype. There was a significant increase of HIV envelope gene diversity, as shown by a heteroduplex mobility assay, in advanced disease; this may partly underlie the increase of HIV replication in MDM. Unlike blood isolates (even those from patients with advanced disease), tissue isolates displayed greater similarities (90%) in productive infection between MDM and monocytes. The majority (87%) of all isolates, including those from patients with advanced disease, used CCR5, and only 5 of 37 isolates showed expanded coreceptor usage. These results indicate that in the late stage of disease with increasing viral load and diversity, CCR5 utilization and M-tropism persist in blood and tissue and the replicative ability in macrophages increases. This suggests that these characteristics are advantageous to HIV and are important to disease progression." @default.
• W2135781036 created "2016-06-24" @default.
• W2135781036 creator A5018086400 @default.
• W2135781036 creator A5026553554 @default.
• W2135781036 creator A5027497045 @default.
• W2135781036 creator A5033123518 @default.
• W2135781036 creator A5057705322 @default.
• W2135781036 creator A5071365073 @default.
• W2135781036 creator A5080291803 @default.
• W2135781036 date "1999-12-01" @default.
• W2135781036 modified "2023-10-14" @default.
• W2135781036 title "Persistent CCR5 Utilization and Enhanced Macrophage Tropism by Primary Blood Human Immunodeficiency Virus Type 1 Isolates from Advanced Stages of Disease and Comparison to Tissue-Derived Isolates" @default.
• W2135781036 cites W116133847 @default.
• W2135781036 cites W1532718280 @default.
• W2135781036 cites W1545701301 @default.
• W2135781036 cites W1596576376 @default.
• W2135781036 cites W1598711637 @default.
• W2135781036 cites W1623426438 @default.
• W2135781036 cites W1642524132 @default.
• W2135781036 cites W1723922714 @default.
• W2135781036 cites W1726325960 @default.
• W2135781036 cites W1739595091 @default.
• W2135781036 cites W1782049572 @default.
• W2135781036 cites W1811218957 @default.
• W2135781036 cites W1817018401 @default.
• W2135781036 cites W1879790343 @default.
• W2135781036 cites W1881691580 @default.
• W2135781036 cites W1900729316 @default.
• W2135781036 cites W1918933327 @default.
• W2135781036 cites W1946734657 @default.
• W2135781036 cites W1953822958 @default.
• W2135781036 cites W1963855922 @default.
• W2135781036 cites W1965019797 @default.
• W2135781036 cites W1965757034 @default.
• W2135781036 cites W1970134919 @default.
• W2135781036 cites W1974839791 @default.
• W2135781036 cites W1976466060 @default.
• W2135781036 cites W1981228431 @default.
• W2135781036 cites W1981440980 @default.
• W2135781036 cites W1981644527 @default.
• W2135781036 cites W1983513633 @default.
• W2135781036 cites W1989035987 @default.
• W2135781036 cites W1990028169 @default.
• W2135781036 cites W1995314344 @default.
• W2135781036 cites W1996183144 @default.
• W2135781036 cites W1998990074 @default.
• W2135781036 cites W2000309384 @default.
• W2135781036 cites W2004319639 @default.
• W2135781036 cites W2007989611 @default.
• W2135781036 cites W2019508559 @default.
• W2135781036 cites W2020862791 @default.
• W2135781036 cites W2022770520 @default.
• W2135781036 cites W2032118018 @default.
• W2135781036 cites W2034053987 @default.
• W2135781036 cites W2034430377 @default.
• W2135781036 cites W2035290831 @default.
• W2135781036 cites W2037793240 @default.
• W2135781036 cites W2038904774 @default.
• W2135781036 cites W2042601802 @default.
• W2135781036 cites W2062229947 @default.
• W2135781036 cites W2066121768 @default.
• W2135781036 cites W2069407559 @default.
• W2135781036 cites W2070140544 @default.
• W2135781036 cites W2082737563 @default.
• W2135781036 cites W2088271176 @default.
• W2135781036 cites W2097183306 @default.
• W2135781036 cites W2099982660 @default.
• W2135781036 cites W2105307973 @default.
• W2135781036 cites W2106333535 @default.
• W2135781036 cites W2108256128 @default.
• W2135781036 cites W2119630025 @default.
• W2135781036 cites W2121538004 @default.
• W2135781036 cites W2123778842 @default.
• W2135781036 cites W2123804736 @default.
• W2135781036 cites W2124175534 @default.
• W2135781036 cites W2126255146 @default.
• W2135781036 cites W2131376910 @default.
• W2135781036 cites W2136760141 @default.
• W2135781036 cites W2138901765 @default.
• W2135781036 cites W2142809896 @default.
• W2135781036 cites W2143663670 @default.
• W2135781036 cites W2145378126 @default.
• W2135781036 cites W2148701827 @default.
• W2135781036 cites W2154205595 @default.
• W2135781036 cites W2155117467 @default.
• W2135781036 cites W2156632979 @default.
• W2135781036 cites W2156694786 @default.
• W2135781036 cites W2159899578 @default.
• W2135781036 cites W2163611230 @default.
• W2135781036 cites W2164042883 @default.
• W2135781036 cites W2169186537 @default.
• W2135781036 cites W2170219825 @default.
• W2135781036 cites W2416672167 @default.
• W2135781036 cites W4248096216 @default.
• W2135781036 cites W4313348020 @default.
• W2135781036 doi "https://doi.org/10.1128/jvi.73.12.9741-9755.1999" @default.
• W2135781036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/113021" @default.
• W2135781036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10559284" @default.

• next