FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135794174> ?p ?o ?g. }

• W2135794174 endingPage "693" @default.
• W2135794174 startingPage "d686" @default.
• W2135794174 abstract "Previously held views that the pathogenesis of idiopathic osteoarthritis (OA) originated in the synovial joint and was not influenced by systemic metabolic disturbances in the patient is inconsistent with recent data demonstrate skewing of the growth hormone/insulin-like growth factor-1 axis in the symptomatic OA patient. In light of this novel information, the role of growth hormone and insulin-like growth factor-1 in the pathogenesis and progression of OA requires further definition. In male patients with OA, the red blood cell sequesters more growth hormone than an aged-matched control group. Thus, this growth hormone depot may provide a mechanism for removal of toxic levels of growth hormone from the circulation. Storage of excess growth hormone in red cells may reduce the inflammatory or otherwise undesirable toxic actions of GH. In some patients, serum growth hormones levels may exceed three-times the average value considered normal. These episodic variations in growth hormone levels may play a significant role in the elevated levels of serum growth hormone seen in the OA patient. The connection between elevated growth hormone and decreased insulin-like growth factor-1 levels and the defined cartilage anabolic and catabolic pathways defined in in vitro assays of articular cartilage derived from the OA patients remain to be more precisely defined. However, the dampened insulin-like growth factor-1 response in OA coupled with elevated cartilage extracellular matrix degradation (mediated by metalloproteinases) and depressed compensatory biosynthesis (induced and perpetuated by the presence of cytokines such as interleukin-1 and tumor necrosis factor-alpha) may, in fact, act synergistically to suppress normal cartilage repair mechanisms thus resulting in progressive destructive lesions of the cartilage and bone." @default.
• W2135794174 created "2016-06-24" @default.
• W2135794174 creator A5037419784 @default.
• W2135794174 creator A5087077331 @default.
• W2135794174 date "1999-01-01" @default.
• W2135794174 modified "2023-09-25" @default.
• W2135794174 title "Metabolic disturbances and synovial joint responses in osteoarthritis" @default.
• W2135794174 cites W1483751226 @default.
• W2135794174 cites W1486701492 @default.
• W2135794174 cites W1588094592 @default.
• W2135794174 cites W1861255861 @default.
• W2135794174 cites W1928161708 @default.
• W2135794174 cites W1977837843 @default.
• W2135794174 cites W1979972616 @default.
• W2135794174 cites W1980354900 @default.
• W2135794174 cites W1984112291 @default.
• W2135794174 cites W1992286141 @default.
• W2135794174 cites W1993347338 @default.
• W2135794174 cites W1996499844 @default.
• W2135794174 cites W1999253223 @default.
• W2135794174 cites W2001577896 @default.
• W2135794174 cites W2003152672 @default.
• W2135794174 cites W2003470108 @default.
• W2135794174 cites W2003875220 @default.
• W2135794174 cites W2004488501 @default.
• W2135794174 cites W2014262484 @default.
• W2135794174 cites W2014972722 @default.
• W2135794174 cites W2017045877 @default.
• W2135794174 cites W2017058359 @default.
• W2135794174 cites W2023623228 @default.
• W2135794174 cites W2028088957 @default.
• W2135794174 cites W2034919108 @default.
• W2135794174 cites W2041865050 @default.
• W2135794174 cites W2041999616 @default.
• W2135794174 cites W2051113263 @default.
• W2135794174 cites W2061956760 @default.
• W2135794174 cites W2069545710 @default.
• W2135794174 cites W2072507547 @default.
• W2135794174 cites W2074860567 @default.
• W2135794174 cites W2082950410 @default.
• W2135794174 cites W2085697626 @default.
• W2135794174 cites W2089437280 @default.
• W2135794174 cites W2090464741 @default.
• W2135794174 cites W2098015378 @default.
• W2135794174 cites W2114769400 @default.
• W2135794174 cites W2125096318 @default.
• W2135794174 cites W2128268989 @default.
• W2135794174 cites W2138960046 @default.
• W2135794174 cites W2287771163 @default.
• W2135794174 cites W2343137005 @default.
• W2135794174 cites W2395128180 @default.
• W2135794174 cites W2400107839 @default.
• W2135794174 cites W2411425406 @default.
• W2135794174 cites W2412051933 @default.
• W2135794174 cites W2412994059 @default.
• W2135794174 cites W2415701306 @default.
• W2135794174 cites W2417015271 @default.
• W2135794174 cites W2418283264 @default.
• W2135794174 cites W2431310505 @default.
• W2135794174 cites W2461920409 @default.
• W2135794174 cites W2472051995 @default.
• W2135794174 cites W26378832 @default.
• W2135794174 cites W2186136111 @default.
• W2135794174 doi "https://doi.org/10.2741/a465" @default.
• W2135794174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10525474" @default.
• W2135794174 hasPublicationYear "1999" @default.
• W2135794174 type Work @default.
• W2135794174 sameAs 2135794174 @default.
• W2135794174 citedByCount "29" @default.
• W2135794174 countsByYear W21357941742012 @default.
• W2135794174 countsByYear W21357941742013 @default.
• W2135794174 countsByYear W21357941742017 @default.
• W2135794174 countsByYear W21357941742018 @default.
• W2135794174 crossrefType "journal-article" @default.
• W2135794174 hasAuthorship W2135794174A5037419784 @default.
• W2135794174 hasAuthorship W2135794174A5087077331 @default.
• W2135794174 hasConcept C1008401 @default.
• W2135794174 hasConcept C105702510 @default.
• W2135794174 hasConcept C126322002 @default.
• W2135794174 hasConcept C134018914 @default.
• W2135794174 hasConcept C142724271 @default.
• W2135794174 hasConcept C170493617 @default.
• W2135794174 hasConcept C204787440 @default.
• W2135794174 hasConcept C2775960820 @default.
• W2135794174 hasConcept C2776164576 @default.
• W2135794174 hasConcept C2777433750 @default.
• W2135794174 hasConcept C2779306644 @default.
• W2135794174 hasConcept C2780550940 @default.
• W2135794174 hasConcept C2780689927 @default.
• W2135794174 hasConcept C2780942790 @default.
• W2135794174 hasConcept C2984496839 @default.
• W2135794174 hasConcept C62231903 @default.
• W2135794174 hasConcept C71315377 @default.
• W2135794174 hasConcept C71924100 @default.
• W2135794174 hasConcept C96942376 @default.
• W2135794174 hasConceptScore W2135794174C1008401 @default.
• W2135794174 hasConceptScore W2135794174C105702510 @default.
• W2135794174 hasConceptScore W2135794174C126322002 @default.

• next