Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135799619> ?p ?o ?g. }
- W2135799619 endingPage "129" @default.
- W2135799619 startingPage "124" @default.
- W2135799619 abstract "Abstract: The purpose of this study was to examine the in vivo effect of melatonin (MEL) on peroxynitrite‐induced tau hyperphosphorylation and the involvement of glycogen synthase kinase‐3 β (GSK‐3 β ) and mitogen‐activated protein kinase (MAPK) families. Melatonin was injected into the right cerebroventricle of the rats 1 hr before the bilateral hippocampal injection of 3‐morpholino‐sydnonimine chloride (SIN‐1), the recognized donor of peroxynitrite. Thereafter, the phosphorylation level of tau and the activity of the kinases were analyzed. The injection of SIN‐1 induced hyperphosphorylation of tau at pS396 epitope with a concomitant activation of GSK‐3 β and selective MAPK isoforms including p38 α , p38 β , and p38 δ but not p38 γ . The effect of peroxynitrite was confirmed using uric acid, a recognized scavenger of peroxynitrite. Preinjection of MEL significantly arrested the peroxynitrite‐induced hyperphosphorylation of tau and the activation of GSK‐3 β and MAPKs. Melatonin also ameliorated peroxynitrite‐induced oxidative stress. We conclude that MEL can efficiently arrest peroxynitrite‐induced tau hyperphosphorylation, and the underlying mechanism may involve scavenging the reactive species and suppressing the activated GSK‐3 β and p38 MAPK family." @default.
- W2135799619 created "2016-06-24" @default.
- W2135799619 creator A5017730870 @default.
- W2135799619 creator A5019083606 @default.
- W2135799619 creator A5024286594 @default.
- W2135799619 creator A5045108074 @default.
- W2135799619 creator A5053155039 @default.
- W2135799619 creator A5065591432 @default.
- W2135799619 creator A5085309923 @default.
- W2135799619 date "2006-06-22" @default.
- W2135799619 modified "2023-10-12" @default.
- W2135799619 title "Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain" @default.
- W2135799619 cites W1531617031 @default.
- W2135799619 cites W1611407165 @default.
- W2135799619 cites W1662308449 @default.
- W2135799619 cites W1969941249 @default.
- W2135799619 cites W1978601789 @default.
- W2135799619 cites W1979780091 @default.
- W2135799619 cites W1981289966 @default.
- W2135799619 cites W1982423045 @default.
- W2135799619 cites W1987162834 @default.
- W2135799619 cites W1995515835 @default.
- W2135799619 cites W1995562130 @default.
- W2135799619 cites W1997724028 @default.
- W2135799619 cites W1997829503 @default.
- W2135799619 cites W1998440070 @default.
- W2135799619 cites W2006272352 @default.
- W2135799619 cites W2010222538 @default.
- W2135799619 cites W2013149569 @default.
- W2135799619 cites W2017610138 @default.
- W2135799619 cites W2018424788 @default.
- W2135799619 cites W2024741275 @default.
- W2135799619 cites W2025517512 @default.
- W2135799619 cites W2031999073 @default.
- W2135799619 cites W2034184306 @default.
- W2135799619 cites W2034868356 @default.
- W2135799619 cites W2041049927 @default.
- W2135799619 cites W2057682957 @default.
- W2135799619 cites W2059754504 @default.
- W2135799619 cites W2065525116 @default.
- W2135799619 cites W2065559862 @default.
- W2135799619 cites W2066476415 @default.
- W2135799619 cites W2078614391 @default.
- W2135799619 cites W2080595517 @default.
- W2135799619 cites W2086450927 @default.
- W2135799619 cites W2089199359 @default.
- W2135799619 cites W2091330155 @default.
- W2135799619 cites W2100694105 @default.
- W2135799619 cites W2103829129 @default.
- W2135799619 cites W2103913931 @default.
- W2135799619 cites W2104194752 @default.
- W2135799619 cites W2119021947 @default.
- W2135799619 cites W2124121545 @default.
- W2135799619 cites W2125904354 @default.
- W2135799619 cites W2127115979 @default.
- W2135799619 cites W2131480424 @default.
- W2135799619 cites W2132234674 @default.
- W2135799619 cites W2132534755 @default.
- W2135799619 cites W2133454381 @default.
- W2135799619 cites W2141293774 @default.
- W2135799619 cites W2142904884 @default.
- W2135799619 cites W2143771645 @default.
- W2135799619 cites W2145306453 @default.
- W2135799619 cites W2164068160 @default.
- W2135799619 cites W2185085212 @default.
- W2135799619 doi "https://doi.org/10.1111/j.1600-079x.2006.00343.x" @default.
- W2135799619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16879317" @default.
- W2135799619 hasPublicationYear "2006" @default.
- W2135799619 type Work @default.
- W2135799619 sameAs 2135799619 @default.
- W2135799619 citedByCount "34" @default.
- W2135799619 countsByYear W21357996192012 @default.
- W2135799619 countsByYear W21357996192013 @default.
- W2135799619 countsByYear W21357996192014 @default.
- W2135799619 countsByYear W21357996192015 @default.
- W2135799619 countsByYear W21357996192016 @default.
- W2135799619 countsByYear W21357996192017 @default.
- W2135799619 countsByYear W21357996192018 @default.
- W2135799619 countsByYear W21357996192020 @default.
- W2135799619 countsByYear W21357996192021 @default.
- W2135799619 countsByYear W21357996192022 @default.
- W2135799619 crossrefType "journal-article" @default.
- W2135799619 hasAuthorship W2135799619A5017730870 @default.
- W2135799619 hasAuthorship W2135799619A5019083606 @default.
- W2135799619 hasAuthorship W2135799619A5024286594 @default.
- W2135799619 hasAuthorship W2135799619A5045108074 @default.
- W2135799619 hasAuthorship W2135799619A5053155039 @default.
- W2135799619 hasAuthorship W2135799619A5065591432 @default.
- W2135799619 hasAuthorship W2135799619A5085309923 @default.
- W2135799619 hasConcept C11960822 @default.
- W2135799619 hasConcept C126322002 @default.
- W2135799619 hasConcept C134018914 @default.
- W2135799619 hasConcept C181199279 @default.
- W2135799619 hasConcept C182996813 @default.
- W2135799619 hasConcept C184235292 @default.
- W2135799619 hasConcept C185592680 @default.
- W2135799619 hasConcept C2776151105 @default.
- W2135799619 hasConcept C2778182776 @default.