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- W2135808879 endingPage "38" @default.
- W2135808879 startingPage "32" @default.
- W2135808879 abstract "The discovery of safe and effective therapies for perinatal hypoxia ischemia (HI) and stroke remains an unmet goal of neonatal-perinatal medicine. Because of the many developmental and functional differences between the neonatal brain and the adult brain, the ability to extrapolate adult data to the neonatal condition is very limited. For this reason, it is incumbent on scientists in the field of neonatal brain injury to address the questions of therapeutic efficacy of an array of potential therapies in a developmentally appropriate model. Toward that end, a number of new models of neonatal HI and stroke have been introduced recently. Additionally, some of the established models have been adapted to different species and different ages, giving scientists a greater choice of models for the study of neonatal HI and stroke. Many of these models are now also being used for functional and behavioral testing, an absolute necessity for preclinical therapeutic trials. This review focuses primarily on the newly developed models, recent adaptations to established models, and the studies of functional outcome that have been published since 2000." @default.
- W2135808879 created "2016-06-24" @default.
- W2135808879 creator A5008837643 @default.
- W2135808879 date "2006-01-01" @default.
- W2135808879 modified "2023-09-30" @default.
- W2135808879 title "Brief Update on Animal Models of Hypoxic-Ischemic Encephalopathy and Neonatal Stroke" @default.
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- W2135808879 doi "https://doi.org/10.1093/ilar.47.1.32" @default.
- W2135808879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16391429" @default.
- W2135808879 hasPublicationYear "2006" @default.