FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135831304> ?p ?o ?g. }

• W2135831304 endingPage "677" @default.
• W2135831304 startingPage "671" @default.
• W2135831304 abstract "We have studied the interaction of the reversible acetylcholine esterase inhibitor (-)physostigmine (D-eserine) with the nicotinic acetylcholine receptor (nAChR) from Torpedo marmorata electric tissue by means of ligand-induced ion flux into nAChR-rich membrane vesicles and of equilibrium binding. We find that (-) physostigmine induces cation flux (and also binds to the receptor) even in the presence of saturating concentrations of antagonists of acetylcholine, such as D-tubocurarine, alpha-bungarotoxin or antibody WF6. The direct action on the acetylcholine receptor is not affected by removal of the methylcarbamate function from the drug and thus is not due to carbamylation of the receptor. Antibodies FK1 and benzoquinonium antagonize channel activation (and binding) of eserine, suggesting that the eserine binding site(s) is separate from, but adjacent to, the acetylcholine binding site at the receptor. In addition to the channel activating site(s) with an affinity of binding in the 50 microM range, there exists a further class of low-affinity (Kd approximately mM) sites from which eserine acts as a direct blocker of the acetylcholine-activated channel. Our results suggest the existence of a second pathway of activation of the nAChR channel." @default.
• W2135831304 created "2016-06-24" @default.
• W2135831304 creator A5040616883 @default.
• W2135831304 creator A5067665301 @default.
• W2135831304 creator A5074867425 @default.
• W2135831304 date "1991-09-01" @default.
• W2135831304 modified "2023-09-26" @default.
• W2135831304 title "A second pathway of activation of the Torpedo acetylcholine receptor channel" @default.
• W2135831304 cites W104057338 @default.
• W2135831304 cites W1487535219 @default.
• W2135831304 cites W1509118314 @default.
• W2135831304 cites W1583381215 @default.
• W2135831304 cites W1592469478 @default.
• W2135831304 cites W170493551 @default.
• W2135831304 cites W1864322269 @default.
• W2135831304 cites W1965142345 @default.
• W2135831304 cites W1986920910 @default.
• W2135831304 cites W1998236920 @default.
• W2135831304 cites W2006798674 @default.
• W2135831304 cites W2009159998 @default.
• W2135831304 cites W2009224927 @default.
• W2135831304 cites W2009667219 @default.
• W2135831304 cites W2011696262 @default.
• W2135831304 cites W2012315029 @default.
• W2135831304 cites W2013398602 @default.
• W2135831304 cites W2018117360 @default.
• W2135831304 cites W2040955328 @default.
• W2135831304 cites W2048709188 @default.
• W2135831304 cites W2050406892 @default.
• W2135831304 cites W2056654465 @default.
• W2135831304 cites W2060165845 @default.
• W2135831304 cites W2060924198 @default.
• W2135831304 cites W2063153410 @default.
• W2135831304 cites W2066180201 @default.
• W2135831304 cites W2070448038 @default.
• W2135831304 cites W2071252954 @default.
• W2135831304 cites W2077866525 @default.
• W2135831304 cites W2078814148 @default.
• W2135831304 cites W2083269122 @default.
• W2135831304 cites W2088748706 @default.
• W2135831304 cites W2159792430 @default.
• W2135831304 cites W227476694 @default.
• W2135831304 cites W2428438473 @default.
• W2135831304 cites W2473692336 @default.
• W2135831304 cites W66493300 @default.
• W2135831304 doi "https://doi.org/10.1111/j.1432-1033.1991.tb16231.x" @default.
• W2135831304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1717267" @default.
• W2135831304 hasPublicationYear "1991" @default.
• W2135831304 type Work @default.
• W2135831304 sameAs 2135831304 @default.
• W2135831304 citedByCount "67" @default.
• W2135831304 countsByYear W21358313042012 @default.
• W2135831304 countsByYear W21358313042013 @default.
• W2135831304 countsByYear W21358313042014 @default.
• W2135831304 countsByYear W21358313042018 @default.
• W2135831304 countsByYear W21358313042020 @default.
• W2135831304 countsByYear W21358313042023 @default.
• W2135831304 crossrefType "journal-article" @default.
• W2135831304 hasAuthorship W2135831304A5040616883 @default.
• W2135831304 hasAuthorship W2135831304A5067665301 @default.
• W2135831304 hasAuthorship W2135831304A5074867425 @default.
• W2135831304 hasConcept C107824862 @default.
• W2135831304 hasConcept C116289061 @default.
• W2135831304 hasConcept C123419017 @default.
• W2135831304 hasConcept C12554922 @default.
• W2135831304 hasConcept C170493617 @default.
• W2135831304 hasConcept C185592680 @default.
• W2135831304 hasConcept C188987157 @default.
• W2135831304 hasConcept C2775910092 @default.
• W2135831304 hasConcept C2776663719 @default.
• W2135831304 hasConcept C2779570518 @default.
• W2135831304 hasConcept C55493867 @default.
• W2135831304 hasConcept C64615621 @default.
• W2135831304 hasConcept C80161118 @default.
• W2135831304 hasConcept C86803240 @default.
• W2135831304 hasConcept C98274493 @default.
• W2135831304 hasConceptScore W2135831304C107824862 @default.
• W2135831304 hasConceptScore W2135831304C116289061 @default.
• W2135831304 hasConceptScore W2135831304C123419017 @default.
• W2135831304 hasConceptScore W2135831304C12554922 @default.
• W2135831304 hasConceptScore W2135831304C170493617 @default.
• W2135831304 hasConceptScore W2135831304C185592680 @default.
• W2135831304 hasConceptScore W2135831304C188987157 @default.
• W2135831304 hasConceptScore W2135831304C2775910092 @default.
• W2135831304 hasConceptScore W2135831304C2776663719 @default.
• W2135831304 hasConceptScore W2135831304C2779570518 @default.
• W2135831304 hasConceptScore W2135831304C55493867 @default.
• W2135831304 hasConceptScore W2135831304C64615621 @default.
• W2135831304 hasConceptScore W2135831304C80161118 @default.
• W2135831304 hasConceptScore W2135831304C86803240 @default.
• W2135831304 hasConceptScore W2135831304C98274493 @default.
• W2135831304 hasIssue "3" @default.
• W2135831304 hasLocation W21358313041 @default.
• W2135831304 hasLocation W21358313042 @default.
• W2135831304 hasOpenAccess W2135831304 @default.
• W2135831304 hasPrimaryLocation W21358313041 @default.
• W2135831304 hasRelatedWork W1968377667 @default.
• W2135831304 hasRelatedWork W2031343424 @default.

• next