FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135833274> ?p ?o ?g. }

• W2135833274 endingPage "954" @default.
• W2135833274 startingPage "948" @default.
• W2135833274 abstract "Protracted systemic inflammation has been associated with adverse effects on cognition and brain structure and may accelerate neurodegenerative disease processes; however, it is less clear whether changes in inflammation are associated with brain structure. We studied 276 black and white older adults (mean age = 83 years at time of imaging) enrolled in a prospective study of aging. Inflammation (measured with c-reactive protein, CRP) was assessed repeatedly over 6 years (i.e., year 2, 4, 6, and 8). Brain magnetic resonance imaging (MRIs) were obtained at years 10-11 with diffusion tensor imaging; regions of interest included late-myelinating areas vulnerable to aging, including frontal-parietal (superior longitudinal fasciculus [SLF]-dorsal) and temporal (SLF-temporal; uncinate) white matter tracts. Mean CRP values significantly declined (t = -5.54, p < 0.0001) over 6 years, and subject-specific slopes (best linear unbiased predictors of slopes) all showed a decline (mean = -0.57, standard deviation = 0.53) for our participant sample. More than 50% of study participants were still in the moderate to high cardiovascular risk range based on CRP values at year 8. After controlling for demographics, vascular risk factors and MRI white matter hyperintensities, larger decreases in CRP values over time were significantly associated with higher fractional anisotropy in the SLF-dorsal (beta = -0.0052, standard error [SE] = 0.003; 95% confidence interval [CI] = -0.0103 to -0.0025, p = 0.04), SLF-temporal (beta = -0.0109, SE = 0.004; 95% CI = -0.0189 to -0.0029, p = 0.008), and uncinate (beta = -0.0067, SE = 0.003; 95% CI = -0.0132 to -0.0001, p = 0.05) fasciculi. Results suggest that in a prospective cohort of older individuals, faster declines in inflammation over time are related to indicators of white matter health, even after accounting for vascular risk factors." @default.
• W2135833274 created "2016-06-24" @default.
• W2135833274 creator A5007432044 @default.
• W2135833274 creator A5017749001 @default.
• W2135833274 creator A5018722034 @default.
• W2135833274 creator A5022120351 @default.
• W2135833274 creator A5055337948 @default.
• W2135833274 creator A5056508217 @default.
• W2135833274 creator A5062324929 @default.
• W2135833274 creator A5067387552 @default.
• W2135833274 creator A5078009095 @default.
• W2135833274 creator A5087201620 @default.
• W2135833274 creator A5089876350 @default.
• W2135833274 date "2015-02-01" @default.
• W2135833274 modified "2023-09-23" @default.
• W2135833274 title "Declines in inflammation predict greater white matter microstructure in older adults" @default.
• W2135833274 cites W1501048741 @default.
• W2135833274 cites W1516326586 @default.
• W2135833274 cites W1518273993 @default.
• W2135833274 cites W1523984875 @default.
• W2135833274 cites W1965801493 @default.
• W2135833274 cites W1971200109 @default.
• W2135833274 cites W1974460091 @default.
• W2135833274 cites W1983906797 @default.
• W2135833274 cites W1985783583 @default.
• W2135833274 cites W1994006394 @default.
• W2135833274 cites W1995854455 @default.
• W2135833274 cites W1997782235 @default.
• W2135833274 cites W2003191738 @default.
• W2135833274 cites W2006096283 @default.
• W2135833274 cites W2006823107 @default.
• W2135833274 cites W2010556599 @default.
• W2135833274 cites W2012110465 @default.
• W2135833274 cites W2012747049 @default.
• W2135833274 cites W2021652661 @default.
• W2135833274 cites W2022206202 @default.
• W2135833274 cites W2022530159 @default.
• W2135833274 cites W2028159706 @default.
• W2135833274 cites W2042622892 @default.
• W2135833274 cites W2045353197 @default.
• W2135833274 cites W2054435322 @default.
• W2135833274 cites W2055857680 @default.
• W2135833274 cites W2058486187 @default.
• W2135833274 cites W2058610272 @default.
• W2135833274 cites W2058965862 @default.
• W2135833274 cites W2065028487 @default.
• W2135833274 cites W2065123450 @default.
• W2135833274 cites W2081501019 @default.
• W2135833274 cites W2089992542 @default.
• W2135833274 cites W2093307631 @default.
• W2135833274 cites W2093984890 @default.
• W2135833274 cites W2104909085 @default.
• W2135833274 cites W2106118263 @default.
• W2135833274 cites W2112778345 @default.
• W2135833274 cites W2119222382 @default.
• W2135833274 cites W2123019462 @default.
• W2135833274 cites W2128722360 @default.
• W2135833274 cites W2130459099 @default.
• W2135833274 cites W2135568455 @default.
• W2135833274 cites W2140642073 @default.
• W2135833274 cites W2145045466 @default.
• W2135833274 cites W2146858278 @default.
• W2135833274 cites W2149814390 @default.
• W2135833274 cites W2149954869 @default.
• W2135833274 cites W2150191386 @default.
• W2135833274 cites W2150667092 @default.
• W2135833274 cites W2157035009 @default.
• W2135833274 cites W2164189703 @default.
• W2135833274 cites W231832547 @default.
• W2135833274 cites W2395337988 @default.
• W2135833274 cites W2470545058 @default.
• W2135833274 doi "https://doi.org/10.1016/j.neurobiolaging.2014.11.004" @default.
• W2135833274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4339188" @default.
• W2135833274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25554492" @default.
• W2135833274 hasPublicationYear "2015" @default.
• W2135833274 type Work @default.
• W2135833274 sameAs 2135833274 @default.
• W2135833274 citedByCount "30" @default.
• W2135833274 countsByYear W21358332742015 @default.
• W2135833274 countsByYear W21358332742016 @default.
• W2135833274 countsByYear W21358332742017 @default.
• W2135833274 countsByYear W21358332742018 @default.
• W2135833274 countsByYear W21358332742019 @default.
• W2135833274 countsByYear W21358332742020 @default.
• W2135833274 countsByYear W21358332742021 @default.
• W2135833274 countsByYear W21358332742022 @default.
• W2135833274 countsByYear W21358332742023 @default.
• W2135833274 crossrefType "journal-article" @default.
• W2135833274 hasAuthorship W2135833274A5007432044 @default.
• W2135833274 hasAuthorship W2135833274A5017749001 @default.
• W2135833274 hasAuthorship W2135833274A5018722034 @default.
• W2135833274 hasAuthorship W2135833274A5022120351 @default.
• W2135833274 hasAuthorship W2135833274A5055337948 @default.
• W2135833274 hasAuthorship W2135833274A5056508217 @default.
• W2135833274 hasAuthorship W2135833274A5062324929 @default.
• W2135833274 hasAuthorship W2135833274A5067387552 @default.
• W2135833274 hasAuthorship W2135833274A5078009095 @default.
• W2135833274 hasAuthorship W2135833274A5087201620 @default.

• next