Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135870323> ?p ?o ?g. }
- W2135870323 endingPage "316" @default.
- W2135870323 startingPage "304" @default.
- W2135870323 abstract "Bone and soft tissue sarcomas are an infrequent and heterogeneous group of mesenchymal tumors, including more than a hundred different entities attending to histological patterns. Sarcomas are quite resistant to conventional chemotherapy (anthracycline and ifosfamide) with the exception of some subtypes, such as Ewing's sarcoma (ES). New drugs with proved efficacy against sarcomas include taxanes, gemcitabine, and ET-743. Preclinical studies have also identified key molecular events leading to the progression and development of sarcomas which are good candidates to targeted therapy. Inhibitors of the tyrosine kinase receptors, such as IGF-1R, c-kit, PDGFR, VEGFR, or the mTOR signaling pathway, proteasome, angiogenesis, and stress response proteins are under clinical evaluation against sarcomas. ES, a tumor characterized by chromosomal translocations that originate gene fusions (EWS-FLI1, EWS-ERG), is an example of a good chemotherapy responder tumor whose survival rate shows a plateau in recent years. Preclinical studies have identified that new targets such as HSP90 are of relevance to ES. On the other hand, recent studies showed the role of cancer stem cells (CSCs) in sarcomas and the relevance of the identification of reliable molecular markers and possible therapeutic targets. New therapeutic approaches could be directed against CSCs. This review describes more recent targeted therapy in sarcomas, with special emphasis on ES and the role of CSCs. We also emphasize the role of high throughput proteomic techniques in identifying new therapeutic targets." @default.
- W2135870323 created "2016-06-24" @default.
- W2135870323 creator A5006108242 @default.
- W2135870323 creator A5012392244 @default.
- W2135870323 creator A5013489598 @default.
- W2135870323 creator A5044250695 @default.
- W2135870323 creator A5085470464 @default.
- W2135870323 date "2008-11-01" @default.
- W2135870323 modified "2023-10-03" @default.
- W2135870323 title "Targeting sarcomas: therapeutic targets and their rational" @default.
- W2135870323 cites W1492422933 @default.
- W2135870323 cites W1789215739 @default.
- W2135870323 cites W1892156002 @default.
- W2135870323 cites W1924823925 @default.
- W2135870323 cites W192608075 @default.
- W2135870323 cites W1931843124 @default.
- W2135870323 cites W1968816294 @default.
- W2135870323 cites W1971190195 @default.
- W2135870323 cites W1975558168 @default.
- W2135870323 cites W1978922759 @default.
- W2135870323 cites W1980711299 @default.
- W2135870323 cites W1981301410 @default.
- W2135870323 cites W1988976358 @default.
- W2135870323 cites W1989054824 @default.
- W2135870323 cites W1989342167 @default.
- W2135870323 cites W1990757263 @default.
- W2135870323 cites W1990794205 @default.
- W2135870323 cites W1991951536 @default.
- W2135870323 cites W1996979039 @default.
- W2135870323 cites W1997220932 @default.
- W2135870323 cites W1997835441 @default.
- W2135870323 cites W1999030960 @default.
- W2135870323 cites W2000646653 @default.
- W2135870323 cites W2003604425 @default.
- W2135870323 cites W2008979678 @default.
- W2135870323 cites W2009412756 @default.
- W2135870323 cites W2013453542 @default.
- W2135870323 cites W2013883015 @default.
- W2135870323 cites W2015511149 @default.
- W2135870323 cites W2015690088 @default.
- W2135870323 cites W2018279800 @default.
- W2135870323 cites W2020018374 @default.
- W2135870323 cites W2020298300 @default.
- W2135870323 cites W2020564508 @default.
- W2135870323 cites W2022531767 @default.
- W2135870323 cites W2022767090 @default.
- W2135870323 cites W2023096047 @default.
- W2135870323 cites W2025989401 @default.
- W2135870323 cites W2027298187 @default.
- W2135870323 cites W2032270604 @default.
- W2135870323 cites W2032481064 @default.
- W2135870323 cites W2034176492 @default.
- W2135870323 cites W2036463815 @default.
- W2135870323 cites W2037722281 @default.
- W2135870323 cites W2038600624 @default.
- W2135870323 cites W2042155367 @default.
- W2135870323 cites W2042404839 @default.
- W2135870323 cites W2042549882 @default.
- W2135870323 cites W2043436613 @default.
- W2135870323 cites W2046788126 @default.
- W2135870323 cites W2047183534 @default.
- W2135870323 cites W2048514585 @default.
- W2135870323 cites W2051833743 @default.
- W2135870323 cites W2053007772 @default.
- W2135870323 cites W2054712075 @default.
- W2135870323 cites W2055854406 @default.
- W2135870323 cites W2056388928 @default.
- W2135870323 cites W2061054148 @default.
- W2135870323 cites W2061346489 @default.
- W2135870323 cites W2062050739 @default.
- W2135870323 cites W2071993782 @default.
- W2135870323 cites W2073045469 @default.
- W2135870323 cites W2077014658 @default.
- W2135870323 cites W2082138815 @default.
- W2135870323 cites W2083530483 @default.
- W2135870323 cites W2084739604 @default.
- W2135870323 cites W2086849370 @default.
- W2135870323 cites W2087738968 @default.
- W2135870323 cites W2090928430 @default.
- W2135870323 cites W2092817365 @default.
- W2135870323 cites W2093221289 @default.
- W2135870323 cites W2097490615 @default.
- W2135870323 cites W2098114704 @default.
- W2135870323 cites W2099868678 @default.
- W2135870323 cites W2100417824 @default.
- W2135870323 cites W2102249538 @default.
- W2135870323 cites W2102820712 @default.
- W2135870323 cites W2103571364 @default.
- W2135870323 cites W2106364098 @default.
- W2135870323 cites W2108570690 @default.
- W2135870323 cites W2112474467 @default.
- W2135870323 cites W2113855026 @default.
- W2135870323 cites W2116025938 @default.
- W2135870323 cites W2116189789 @default.
- W2135870323 cites W2118471037 @default.
- W2135870323 cites W2119462927 @default.
- W2135870323 cites W2123248195 @default.
- W2135870323 cites W2123302336 @default.