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- W2135880942 abstract "Background Antipsychotic drugs are associated with adverse effects that can lead to poor medication adherence, stigma, distress and impaired quality of life Aims To review the use of adverse effects of antipsychotic drugs as outcome measures, with a particular emphasis on methodological issues Method Review of data on adverse effects from sources including randomised controlled trials (RCTs), post-marketing surveillance and naturalistic studies Results All have advantages and disadvantages and the best overview comes from considering all sources of data together. Adverse effects are inconsistently reported, hampering cross-study comparisons. Many outcome measures lack clinical meaning. In both naturalistic studies and RCTs adverse effects often account for less treatment discontinuation than lack of efficacy Conclusions Standardisation in the reporting of adverse effects is needed. Patients' subjective experience of medication should be given more consideration. Total discontinuation rates provide a useful global outcome measure that incorporates tolerability and efficacy as well as patient and clinician viewpoints. Patients should be informed of common side-effects prior to treatment and monitored for their occurrence during treatment" @default.
- W2135880942 created "2016-06-24" @default.
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- W2135880942 date "2007-08-01" @default.
- W2135880942 modified "2023-10-17" @default.
- W2135880942 title "Adverse effects of antipsychotics as outcome measures" @default.
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- W2135880942 doi "https://doi.org/10.1192/bjp.191.50.s64" @default.
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