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- W2135881373 abstract "Exposure to atmospheric fine particulate matter (PM 2.5 ) is a modifiable risk factor of cardiovascular disease. Ultrafine particles (UFP, diameter <0.1 μm), a subfraction of PM 2.5 , promote vascular oxidative stress and inflammatory responses. Epidemiologic studies suggest that PM exposure promotes vascular calcification. Here, we assessed whether UFP exposure promotes vascular calcification via NF-κB signaling. UFP exposure at 50 μg/ml increased alkaline phosphatase (ALP) activity by 4.4 ± 0.2-fold on day 3 ( n = 3, P < 0.001) and matrix calcification by 3.5 ± 1.7-fold on day 10 ( n = 4, P < 0.05) in calcifying vascular cells (CVC), a subpopulation of vascular smooth muscle cells with osteoblastic potential. Treatment of CVC with conditioned media derived from UFP-treated macrophages (UFP-CM) also led to an increase in ALP activities and matrix calcification. Furthermore, both UFP and UFP-CM significantly increased NF-κB activity, and cotreatment with an NF-κB inhibitor, JSH23, attenuated both UFP- and UFP-CM-induced ALP activity and calcification. When low-density lipoprotein receptor-null mice were exposed to UFP at 359.5 μg/m 3 for 10 wk, NF-κB activation and vascular calcification were detected in the regions of aortic roots compared with control filtered air-exposed mice. These findings suggest that UFP promotes vascular calcification via activating NF-κB signaling." @default.
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- W2135881373 date "2013-02-15" @default.
- W2135881373 modified "2023-09-27" @default.
- W2135881373 title "Atmospheric ultrafine particles promote vascular calcification via the NF-κB signaling pathway" @default.
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- W2135881373 doi "https://doi.org/10.1152/ajpcell.00322.2012" @default.
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