FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135882425> ?p ?o ?g. }

• W2135882425 endingPage "45" @default.
• W2135882425 startingPage "40" @default.
• W2135882425 abstract "Binding to plasma proteins is one of the major metabolic pathways of metallodrugs. In the case of platinum-based anticancer drugs, it is the interaction with serum albumin that affects most strongly their in vivo behavior. Since both the configuration, i.e. cis-trans-isomerism, and the nature of leaving groups have an effect on the reactivity of Pt(II) coordination compounds toward biomolecules, a set of cis- and trans-configured complexes with halide leaving groups (Cl−, Br−, and I−) and 2-propanone oxime as carrier ligands was chosen for this study. Binding experiments were performed both with albumin and human serum and the Pt content in ultrafiltrates was quantified using inductively coupled plasma mass spectrometry. In order to shed light on the binding mechanism, the albumin binding constant (KHSA) and the octanol–water partition coefficient (P) were experimentally determined and relationships between log KHSA and log P were explored. The correlation was found significant only for cis-configured platinum complexes (R2 = 0.997 and standard deviation = 0.02), indicating a certain contribution of the nonspecific binding which is largely dominated by the lipophilicity of compounds. In contrast, for trans-complexes a specific molecular recognition element plays a significant role. The participation of albumin in drug distribution in blood serum was assessed using an equilibrium distribution model and by comparing the percentage binding in the albumin and serum-protein fractions. Irrespective of the compound polarity, albumin contributes from 85 to 100% to the overall binding in serum." @default.
• W2135882425 created "2016-06-24" @default.
• W2135882425 creator A5004914119 @default.
• W2135882425 creator A5034302513 @default.
• W2135882425 creator A5035718082 @default.
• W2135882425 creator A5047275161 @default.
• W2135882425 creator A5051845620 @default.
• W2135882425 creator A5052662655 @default.
• W2135882425 creator A5071820696 @default.
• W2135882425 date "2014-08-01" @default.
• W2135882425 modified "2023-10-11" @default.
• W2135882425 title "Inductively coupled plasma mass spectrometry for metallodrug development: Albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes" @default.
• W2135882425 cites W1974235044 @default.
• W2135882425 cites W1985282657 @default.
• W2135882425 cites W2017758592 @default.
• W2135882425 cites W2049686776 @default.
• W2135882425 cites W2053021523 @default.
• W2135882425 cites W2053141304 @default.
• W2135882425 cites W2059946233 @default.
• W2135882425 cites W2060540813 @default.
• W2135882425 cites W2062642504 @default.
• W2135882425 cites W2070363388 @default.
• W2135882425 cites W2071263650 @default.
• W2135882425 cites W2075028690 @default.
• W2135882425 cites W2076020561 @default.
• W2135882425 cites W2078068896 @default.
• W2135882425 cites W2090700713 @default.
• W2135882425 cites W2095084300 @default.
• W2135882425 cites W2110490413 @default.
• W2135882425 cites W2111176080 @default.
• W2135882425 cites W2111802384 @default.
• W2135882425 cites W2130708058 @default.
• W2135882425 cites W2163122422 @default.
• W2135882425 cites W2313050153 @default.
• W2135882425 cites W2324743082 @default.
• W2135882425 cites W2325878452 @default.
• W2135882425 doi "https://doi.org/10.1016/j.jinorgbio.2014.04.008" @default.
• W2135882425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24803025" @default.
• W2135882425 hasPublicationYear "2014" @default.
• W2135882425 type Work @default.
• W2135882425 sameAs 2135882425 @default.
• W2135882425 citedByCount "26" @default.
• W2135882425 countsByYear W21358824252014 @default.
• W2135882425 countsByYear W21358824252015 @default.
• W2135882425 countsByYear W21358824252016 @default.
• W2135882425 countsByYear W21358824252017 @default.
• W2135882425 countsByYear W21358824252018 @default.
• W2135882425 countsByYear W21358824252019 @default.
• W2135882425 countsByYear W21358824252020 @default.
• W2135882425 countsByYear W21358824252021 @default.
• W2135882425 countsByYear W21358824252022 @default.
• W2135882425 crossrefType "journal-article" @default.
• W2135882425 hasAuthorship W2135882425A5004914119 @default.
• W2135882425 hasAuthorship W2135882425A5034302513 @default.
• W2135882425 hasAuthorship W2135882425A5035718082 @default.
• W2135882425 hasAuthorship W2135882425A5047275161 @default.
• W2135882425 hasAuthorship W2135882425A5051845620 @default.
• W2135882425 hasAuthorship W2135882425A5052662655 @default.
• W2135882425 hasAuthorship W2135882425A5071820696 @default.
• W2135882425 hasConcept C107824862 @default.
• W2135882425 hasConcept C161790260 @default.
• W2135882425 hasConcept C162356407 @default.
• W2135882425 hasConcept C165616093 @default.
• W2135882425 hasConcept C165697059 @default.
• W2135882425 hasConcept C185592680 @default.
• W2135882425 hasConcept C192552737 @default.
• W2135882425 hasConcept C201399114 @default.
• W2135882425 hasConcept C2776125364 @default.
• W2135882425 hasConcept C32786932 @default.
• W2135882425 hasConcept C43617362 @default.
• W2135882425 hasConcept C51639874 @default.
• W2135882425 hasConcept C518104683 @default.
• W2135882425 hasConcept C55493867 @default.
• W2135882425 hasConcept C71240020 @default.
• W2135882425 hasConceptScore W2135882425C107824862 @default.
• W2135882425 hasConceptScore W2135882425C161790260 @default.
• W2135882425 hasConceptScore W2135882425C162356407 @default.
• W2135882425 hasConceptScore W2135882425C165616093 @default.
• W2135882425 hasConceptScore W2135882425C165697059 @default.
• W2135882425 hasConceptScore W2135882425C185592680 @default.
• W2135882425 hasConceptScore W2135882425C192552737 @default.
• W2135882425 hasConceptScore W2135882425C201399114 @default.
• W2135882425 hasConceptScore W2135882425C2776125364 @default.
• W2135882425 hasConceptScore W2135882425C32786932 @default.
• W2135882425 hasConceptScore W2135882425C43617362 @default.
• W2135882425 hasConceptScore W2135882425C51639874 @default.
• W2135882425 hasConceptScore W2135882425C518104683 @default.
• W2135882425 hasConceptScore W2135882425C55493867 @default.
• W2135882425 hasConceptScore W2135882425C71240020 @default.
• W2135882425 hasLocation W21358824251 @default.
• W2135882425 hasLocation W21358824252 @default.
• W2135882425 hasOpenAccess W2135882425 @default.
• W2135882425 hasPrimaryLocation W21358824251 @default.
• W2135882425 hasRelatedWork W1559185053 @default.
• W2135882425 hasRelatedWork W2022386059 @default.
• W2135882425 hasRelatedWork W2024149655 @default.
• W2135882425 hasRelatedWork W2030840504 @default.
• W2135882425 hasRelatedWork W2055928473 @default.

• next