FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135884966> ?p ?o ?g. }

• W2135884966 endingPage "1097" @default.
• W2135884966 startingPage "1087" @default.
• W2135884966 abstract "Acute tryptophan depletion (ATD) is a technique that has been used to evaluate the effects on humans of acutely reducing serotonin neurotransmission. We have developed a model using a single breath of 35% CO2 that activates the hormonal axis and produces autonomic and behavioural arousal, thus modelling a stress response. This study combines ATD and single breath 35% CO2 inhalation to study stress responses in volunteers. A randomised, double-blinded, placebo-controlled, cross-over trial involving 14 healthy adult volunteers aged between 18 and 65 years was undertaken. Subjects underwent double-blind tryptophan depletion over 2 days and were then crossed over 1 week later. During each study day, at the time of peak depletion, participants were single blinded to receive a single breath of 35% CO2 or air. This was followed 40 min later by the other gas. Psychological outcomes were assessed with the Spielberger State Anxiety Inventory (SSAI), Visual Analogue Scales (VAS), Panic Inventory (PI), Panic and Agoraphobia Scale (PSI) and Beck Depression Inventory (BDI). Physiological outcome was measured by serial plasma cortisol, prolactin and tryptophan levels, pulse and blood pressure. Tryptophan depletion did not exacerbate 35% CO2 inhalation effects on anxiety symptoms. Single breath CO2 robustly increased plasma cortisol levels in comparison to an air inhalation; this was less certain for prolactin levels. ATD influenced the HPA axis (associated with higher cortisol levels), apparently independent of CO2 or air inhalation stressors. ATD and 35% CO2 inhalation both induced a pressor response and bradycardia in these normal volunteers. Thirty-five percent CO2 inhalation and ATD independently activate the human stress response, but do not appear to produce synergistic effects when combined, at least for the conditions produced in this study." @default.
• W2135884966 created "2016-06-24" @default.
• W2135884966 creator A5001852870 @default.
• W2135884966 creator A5012264016 @default.
• W2135884966 creator A5012514335 @default.
• W2135884966 creator A5030518299 @default.
• W2135884966 creator A5046408523 @default.
• W2135884966 creator A5069588559 @default.
• W2135884966 date "2006-10-01" @default.
• W2135884966 modified "2023-09-27" @default.
• W2135884966 title "Serotonin regulation of the human stress response" @default.
• W2135884966 cites W1482114328 @default.
• W2135884966 cites W1607171655 @default.
• W2135884966 cites W1969771401 @default.
• W2135884966 cites W1971334427 @default.
• W2135884966 cites W1976021773 @default.
• W2135884966 cites W1977881487 @default.
• W2135884966 cites W1978341871 @default.
• W2135884966 cites W1979885502 @default.
• W2135884966 cites W1983587913 @default.
• W2135884966 cites W1990788335 @default.
• W2135884966 cites W1995051494 @default.
• W2135884966 cites W1997326317 @default.
• W2135884966 cites W1998542626 @default.
• W2135884966 cites W2004470488 @default.
• W2135884966 cites W2015827110 @default.
• W2135884966 cites W2018761568 @default.
• W2135884966 cites W2033397874 @default.
• W2135884966 cites W2034007695 @default.
• W2135884966 cites W2041110988 @default.
• W2135884966 cites W2042026706 @default.
• W2135884966 cites W2044335206 @default.
• W2135884966 cites W2045529234 @default.
• W2135884966 cites W2056575770 @default.
• W2135884966 cites W2065700655 @default.
• W2135884966 cites W2068555985 @default.
• W2135884966 cites W2071359470 @default.
• W2135884966 cites W2078463027 @default.
• W2135884966 cites W2080956512 @default.
• W2135884966 cites W2085839022 @default.
• W2135884966 cites W2091059631 @default.
• W2135884966 cites W2093837465 @default.
• W2135884966 cites W2095628690 @default.
• W2135884966 cites W2101474381 @default.
• W2135884966 cites W2111178305 @default.
• W2135884966 cites W2113082650 @default.
• W2135884966 cites W2113103296 @default.
• W2135884966 cites W2115829407 @default.
• W2135884966 cites W2136681439 @default.
• W2135884966 cites W2137082982 @default.
• W2135884966 cites W2150280168 @default.
• W2135884966 cites W2150460734 @default.
• W2135884966 cites W2156267802 @default.
• W2135884966 cites W2163348409 @default.
• W2135884966 cites W2166762864 @default.
• W2135884966 cites W2231374287 @default.
• W2135884966 cites W2323546369 @default.
• W2135884966 cites W2409959974 @default.
• W2135884966 cites W2245231029 @default.
• W2135884966 cites W2602198223 @default.
• W2135884966 doi "https://doi.org/10.1016/j.psyneuen.2006.07.001" @default.
• W2135884966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16962720" @default.
• W2135884966 hasPublicationYear "2006" @default.
• W2135884966 type Work @default.
• W2135884966 sameAs 2135884966 @default.
• W2135884966 citedByCount "44" @default.
• W2135884966 countsByYear W21358849662012 @default.
• W2135884966 countsByYear W21358849662013 @default.
• W2135884966 countsByYear W21358849662014 @default.
• W2135884966 countsByYear W21358849662015 @default.
• W2135884966 countsByYear W21358849662016 @default.
• W2135884966 countsByYear W21358849662017 @default.
• W2135884966 countsByYear W21358849662019 @default.
• W2135884966 countsByYear W21358849662020 @default.
• W2135884966 countsByYear W21358849662021 @default.
• W2135884966 countsByYear W21358849662022 @default.
• W2135884966 crossrefType "journal-article" @default.
• W2135884966 hasAuthorship W2135884966A5001852870 @default.
• W2135884966 hasAuthorship W2135884966A5012264016 @default.
• W2135884966 hasAuthorship W2135884966A5012514335 @default.
• W2135884966 hasAuthorship W2135884966A5030518299 @default.
• W2135884966 hasAuthorship W2135884966A5046408523 @default.
• W2135884966 hasAuthorship W2135884966A5069588559 @default.
• W2135884966 hasConcept C118552586 @default.
• W2135884966 hasConcept C126322002 @default.
• W2135884966 hasConcept C134018914 @default.
• W2135884966 hasConcept C142724271 @default.
• W2135884966 hasConcept C15744967 @default.
• W2135884966 hasConcept C169760540 @default.
• W2135884966 hasConcept C170493617 @default.
• W2135884966 hasConcept C204787440 @default.
• W2135884966 hasConcept C27081682 @default.
• W2135884966 hasConcept C2775864247 @default.
• W2135884966 hasConcept C2776954882 @default.
• W2135884966 hasConcept C2778678127 @default.
• W2135884966 hasConcept C2778709874 @default.
• W2135884966 hasConcept C2779064019 @default.
• W2135884966 hasConcept C2779631380 @default.

• next