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- W2135890351 abstract "Abstract: The binding of the unselective opioid antagonist [3H]diprenorphine to homogenates prepared from rat brain and from guinea-pig brain and cerebellum has been studied in HEPES buffer containing 10 mM Mg2+ ions. Sequential displacement of bound [3H]diprenorphine by ligands with selectivity for μ-, 8- δ, and k-opioid receptors uncovers the multiple components of binding. In the presence of cold ligands that occupy all μ-, δ-, and k-sites, opioid binding still remains. This binding represents 20% of total specific sites and is displaced by naloxone. The nature of these undefined opioid binding sites is discussed." @default.
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- W2135890351 date "1989-07-01" @default.
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- W2135890351 title "[3H]Diprenorphine Binding to k-Sites in Guinea-Pig and Rat Brain: Evidence for Apparent Heterogeneity" @default.
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- W2135890351 doi "https://doi.org/10.1111/j.1471-4159.1989.tb07310.x" @default.
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