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• W2135890775 endingPage "5162" @default.
• W2135890775 startingPage "5149" @default.
• W2135890775 abstract "Borrelia burgdorferi, the agent of Lyme disease, alters its gene expression in response to highly disparate environmental signals encountered in its hosts. Among the relatively few regulators of adaptive gene expression present in the borrelial genome is an open reading frame (ORF), BB0184, annotated as CsrA (carbon storage regulator A). CsrA, in several bacterial species, has been characterized as a small RNA binding protein that functions as a global regulator affecting mRNA stability or levels of translation of multiple ORFs. Consistent with known functions of CsrA, overexpression of CsrA from B. burgdorferi (CsrABb) in Escherichia coli resulted in reduced accumulation of glycogen. We determined that csrABb is part of the flgK motility operon and that the synthesis of CsrABb was increased when B. burgdorferi was propagated under fed-tick conditions. Overexpression of CsrABb in B. burgdorferi strain B31 (ML23, lp25-negative clonal isolate) resulted in a clone, designated ES25, which exhibited alterations in colony morphology and a significant reduction in the levels of FlaB. Several lipoproteins previously characterized as playing a role in infectivity were also altered in ES25. Real-time reverse transcription-PCR analysis of RNA revealed significant differences in the transcriptional levels of ospC in ES25, while there were no such differences in the levels of other transcripts, suggesting posttranscriptional regulation of expression of these latter genes. These observations indicate that CsrABb plays a role in the regulation of expression of pathophysiological determinants of B. burgdorferi, and further characterization of CsrABb will help in better understanding of the regulators of gene expression in B. burgdorferi." @default.
• W2135890775 created "2016-06-24" @default.
• W2135890775 creator A5037183809 @default.
• W2135890775 creator A5055695025 @default.
• W2135890775 creator A5059848712 @default.
• W2135890775 creator A5088820362 @default.
• W2135890775 date "2009-11-01" @default.
• W2135890775 modified "2023-10-05" @default.
• W2135890775 title "Overexpression of CsrA (BB0184) Alters the Morphology and Antigen Profiles of <i>Borrelia burgdorferi</i>" @default.
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• W2135890775 doi "https://doi.org/10.1128/iai.00673-09" @default.
• W2135890775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2772508" @default.
• W2135890775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19737901" @default.
• W2135890775 hasPublicationYear "2009" @default.

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