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- W2135909428 endingPage "337S" @default.
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- W2135909428 abstract "Recent dietary guidance for heart health recommends a reduction (by ∼50%) in saturated fatty acid (SFA) intake to reduce LDL cholesterol and to decrease risk of cardiovascular disease (CVD). The 2010 Dietary Guidelines for Americans recommends substituting unsaturated fat [both polyunsaturated and monounsaturated fatty acids (PUFAs and MUFAs, respectively)] for SFAs. There are many dietary options that can be implemented to replace SFAs, given the different sources of unsaturated fats in the food supply. Compelling evidence exists for the cardioprotective benefits of n-3 (ω-3) PUFAs, both marine- and plant-derived. In addition, the evidence of cardioprotective benefits of n-6 (ω-6) PUFAs is strong, whereas that for MUFAs is mixed, although there is emerging evidence of benefits. Quantitatively, lowering SFAs by 50% will require, in part, substituting food sources of n-6 and n-3 PUFAs and MUFAs for food sources of SFAs. The use of n-3 PUFAs as a replacement for SFAs will result in a shortfall in reaching the SFA goal because of the relatively low amounts that can be incorporated in the diet, even with very high n-3 PUFA substitution. SFAs also can be replaced with dietary carbohydrate and/or protein. Replacing SFAs with carbohydrate, specifically refined sources, however, has little impact on reducing CVD risk. There is evidence about the health benefits of dietary protein on CVD risk, which merits study. Dietary guidelines have advanced considerably with the replacement of SFA with unsaturated fat message instead of recommending decreasing SFAs alone. A key question that remains is what is the optimal mix of macronutrients to maximally reduce CVD risk." @default.
- W2135909428 created "2016-06-24" @default.
- W2135909428 creator A5078144573 @default.
- W2135909428 creator A5079154529 @default.
- W2135909428 date "2015-05-01" @default.
- W2135909428 modified "2023-09-26" @default.
- W2135909428 title "Emerging Nutrition Science on Fatty Acids and Cardiovascular Disease: Nutritionists' Perspectives" @default.
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- W2135909428 doi "https://doi.org/10.3945/an.114.006981" @default.
- W2135909428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4424771" @default.
- W2135909428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25979506" @default.
- W2135909428 hasPublicationYear "2015" @default.
- W2135909428 type Work @default.