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• W2135909732 abstract "Objective : Human chorionic gonadotropin (hCG) is widely used in the management of hydatidiform mole and persistent trophoblastic disease (PTD). Predicting PTD after molar pregnancy might be beneficial since prophylactic chemotherapy reduces the incidence of PTD. Design : A retrospective study based on blood specimens collected in the Dutch Registry for Hydatidiform Moles. A group of 165 patients with complete moles (of which 43 had PTD) and 39 patients with partial moles (of which 7 had PTD) were compared with 27 pregnant women with uneventful pregnancy. Methods : Serum samples from patients with hydatidiform mole with or without PTD were assayed using specific (radio) immunoassays for free α-subunit (hCGα), free β-subunit (hCGβ) and ‘total’ hCG (hCG + hCGβ). In addition, we calculated the ratios hCGα/hCG + hCGβ, hCGβ/hCG + hCGβ, and hCGα/hCGβ. Specificity and sensitivity were calculated and paired in receiver-operating characteristic (ROC) curve analysis, resulting in areas under the curves (AUCs). Results : hCGβ, hCGβ/hCG + hCGβ and hCGα/hCGβ show AUCs ranging between 0.922 and 0.999 and, therefore, are excellent diagnostic tests to distinguish complete and partial moles from normal pregnancy. To distinguish partial from complete moles the analytes hCGβ, hCG + hCGβ and the ratio hCGα/hCGβ have AUCs between 0.7 and 0.8. Although hCGα, hCGβ and hCG + hCGβ concentrations are significantly elevated in patients who will develop PTD compared with patients with spontaneous regression after evacuation of their moles, in predicting PTD, these analytes and parameters have AUCs <0.7. Conclusions : Distinction between hydatidiform mole and normal pregnancy is best shown by a single blood specimen with hCGβ, but hCGβ/hCG + hCGβ and hCGα/hCGβ are also excellent diagnostic parameters. To predict PTD, hCGα, hCGβ, hCG + hCGβ and hCGα/hCGβ are moderately accurate tests, although they are not accurate enough to justify prophylactic chemotherapy treatment for prevention of PTD." @default.
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• W2135909732 date "2005-10-01" @default.
• W2135909732 modified "2023-10-18" @default.
• W2135909732 title "Diagnosis of hydatidiform mole and persistent trophoblastic disease: diagnostic accuracy of total human chorionic gonadotropin (hCG), free hCG α- and β-subunits, and their ratios" @default.
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• W2135909732 doi "https://doi.org/10.1530/eje.1.01997" @default.
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