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• W2135910189 endingPage "974" @default.
• W2135910189 startingPage "961" @default.
• W2135910189 abstract "The release of glutamate and GABA is modulated by presynaptic metabotropic glutamate receptors (mGluRs). We used immuno-cytochemical methods to define the location of the group III receptor mGluR7a in glutamatergic and GABAergic terminals innervating GABAergic interneurons and pyramidal cells. Immunoreactivity for mGluR7a was localized in the presynaptic active zone of both identified GABAergic and presumed glutamatergic terminals. Terminals innervating dendritic spines showed a variable level of receptor immunoreactivity, ranging from immunonegative to strongly immunopositive. The frequency of strongly mGluR7a positive terminals innervating the soma and dendrites of mGluR1α/somato-statin-expressing interneurons was very high relative to other neurons. On dendrites that received mGluR7a-enriched gluta-matergic innervation, at least 80% of GABAergic terminals were immunopositive for mGluR7a. On such dendrites virtually all (95%) vasoactive intestinal polypeptide (VIP) positive (GABAergic) terminals were enriched in mGluR7a. The targets of VIP/mGluR7a-expressing terminals were mainly (88%) mGluR1α-expressing interneurons, which were mostly somatostatin immunopositive. Parvalbumin positive terminals were immunonegative for mGluR7a. Some parvalbumin immunoreactive dendrites received strongly mGluR7a positive terminals. The subcellular location, as well as the cell type and synapse-specific distribution of mGluR7a in isocortical neuronal circuits, is homologous to its distribution in the hippo-campus. The specific location of mGluR7a in the presynaptic active zone of both glutamatergic and GABAergic synapses may be related to the proximity of calcium channels and the vesicle fusion machinery. The enrichment of mGluR7a in the main GABAergic, as well as in the glutamatergic, innervation of mGluR1α/somatostatin-expressing interneurons suggests that their activation is under unique regulation by extracellular glutamate." @default.
• W2135910189 created "2016-06-24" @default.
• W2135910189 creator A5085022304 @default.
• W2135910189 date "2002-09-01" @default.
• W2135910189 modified "2023-09-23" @default.
• W2135910189 title "Enrichment of mGluR7a in the Presynaptic Active Zones of GABAergic and Non-GABAergic Terminals on Interneurons in the Rat Somatosensory Cortex" @default.
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• W2135910189 doi "https://doi.org/10.1093/cercor/12.9.961" @default.
• W2135910189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12183395" @default.
• W2135910189 hasPublicationYear "2002" @default.
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