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• W2135911667 abstract "Genotoxicity biomarkers are widely measured in ecotoxicology as molecular toxic endpoints of major environmental pollutants. However, the long-term consequences of such damage still have to be elucidated. Some authors have suggested that the accumulation of unrepaired DNA lesions could explain the embryotoxicity of certain chemical pollutants. As embryotoxicity exerts a direct impact on the recruitment rate, genotoxicity could be closely related to disturbances of ecological concern and produce a possible impact upon population dynamics. The aim of the present work was to study the genotoxicity and the embryotoxicity of three relevant pollutants for oyster embryos: the polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), the synthetic estrogenic hormone, 17α-ethinylestradiol (EE2), and the organochlorine pesticide, endosulfan (ES). For each substance, gamete fertilization was performed and embryo development followed in contaminated reference seawater. Following exposure, embryotoxicity was evaluated by calculating the percentage of abnormal D-larvae obtained at 20 h development. Genotoxicity was measured in parallel by conducting a comet assay on enzymatically dissociated cells of pre-shelled larvae (16 h development). The oxidized DNA base, 8-oxodGuo, was also measured by HPLC coupled to electrochemical detection. For each contaminant, the relationship between genotoxicity and embryotoxicity was then studied to check for the possible significance of genotoxicity in the population dynamics of marine bivalves from polluted areas. For BaP, embryotoxicity and DNA strand breakage were both observed from the lowest tested concentration of 0.2 nM. Induction of 8-oxodGuo was significant from 20 nM. Endosulfan exposure resulted in similar effects for oyster embryos but from higher concentrations and followed a concentration-dependent manner. Embryotoxicity and genotoxicity in terms of DNA strand breaks were observed for endosulfan from 300 and 150 nM, respectively. No change in 8-oxodGuo level was observed following endosulfan exposure. EE2 displayed no toxic effect for oyster embryos within the range of tested concentrations (from 0.02 to 1.7 nM). Taking into account all the data collected during this study, a positive and significant correlation was demonstrated in oyster embryos between genotoxicity as measured by the comet assay and embryotoxicity." @default.
• W2135911667 created "2016-06-24" @default.
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• W2135911667 date "2007-11-01" @default.
• W2135911667 modified "2023-10-03" @default.
• W2135911667 title "Investigating the relationship between embryotoxic and genotoxic effects of benzo[a]pyrene, 17α-ethinylestradiol and endosulfan on Crassostrea gigas embryos" @default.
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• W2135911667 cites W1966594837 @default.
• W2135911667 cites W1973672062 @default.
• W2135911667 cites W1974404053 @default.
• W2135911667 cites W1977089134 @default.
• W2135911667 cites W1982266067 @default.
• W2135911667 cites W1983643631 @default.
• W2135911667 cites W1985682749 @default.
• W2135911667 cites W1987202732 @default.
• W2135911667 cites W1987814457 @default.
• W2135911667 cites W1990131329 @default.
• W2135911667 cites W1990352052 @default.
• W2135911667 cites W1992464773 @default.
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• W2135911667 cites W1996872375 @default.
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• W2135911667 cites W1998965812 @default.
• W2135911667 cites W1999864692 @default.
• W2135911667 cites W2006314665 @default.
• W2135911667 cites W2012963101 @default.
• W2135911667 cites W2013256150 @default.
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• W2135911667 cites W2021288128 @default.
• W2135911667 cites W2025355396 @default.
• W2135911667 cites W2032382155 @default.
• W2135911667 cites W2033064608 @default.
• W2135911667 cites W2035538685 @default.
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• W2135911667 cites W2036450133 @default.
• W2135911667 cites W2037211079 @default.
• W2135911667 cites W2037766564 @default.
• W2135911667 cites W2042161432 @default.
• W2135911667 cites W2043108871 @default.
• W2135911667 cites W2043860149 @default.
• W2135911667 cites W2044465050 @default.
• W2135911667 cites W2046874266 @default.
• W2135911667 cites W2048244792 @default.
• W2135911667 cites W2056291273 @default.
• W2135911667 cites W2059190816 @default.
• W2135911667 cites W2061209381 @default.
• W2135911667 cites W2069669658 @default.
• W2135911667 cites W2078069131 @default.
• W2135911667 cites W2083363203 @default.
• W2135911667 cites W2085013650 @default.
• W2135911667 cites W2085956066 @default.
• W2135911667 cites W2087848150 @default.
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• W2135911667 cites W2107932490 @default.
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• W2135911667 doi "https://doi.org/10.1016/j.aquatox.2007.08.007" @default.
• W2135911667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17904659" @default.
• W2135911667 hasPublicationYear "2007" @default.
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