Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135928749> ?p ?o ?g. }
- W2135928749 endingPage "279" @default.
- W2135928749 startingPage "269" @default.
- W2135928749 abstract "Nucleus raphéobscurus (NRo) modulates hypoglossal (XII) nerve motor output in the in vitro transverse brain stem slice of neonatal rats (1–5 days old); chemical ablation of NRo and its focal CO 2 acidification modulated the bursting rhythm of XII nerves. We microinjected a 4.5 mM solution of kainic acid into the NRo to disrupt cellular activity and observed that XII nerve activity was temporarily abolished ( n = 10). We also microinjected CO 2 -acidified (pH = 6.00 ± 0.01) artificial cerebrospinal fluid (aCSF) into the NRo ( n = 6), the pre-Bötzinger complex (PBC) ( n = 6), as well as a control region in the lateral tegmental field equidistant to NRo, PBC, and the XII motor nuclei ( n = 12). CO 2 acidification of the control region had no effect on XII motor output. CO 2 acidification of the NRo significantly ( P < 0.05) increased the burst discharge frequency of XII nerves by 77%; integrated burst amplitude and burst duration increased by 64% and 52%, respectively. CO 2 acidification of the PBC significantly ( P < 0.05) increased the burst discharge frequency of XII nerves by 65%, but neither integrated burst amplitude nor burst duration changed. These results demonstrate that chemical ablation of the NRo can abolish XII nerve bursting rhythm and that stimulation of the NRo with CO 2 -acidified aCSF can excite XII nerve bursting activity. From these observations, we conclude that, in transverse brain stem slices, the NRo contains pH/CO 2 -sensitive cells that modulate XII motor output." @default.
- W2135928749 created "2016-06-24" @default.
- W2135928749 creator A5008490043 @default.
- W2135928749 creator A5019352493 @default.
- W2135928749 creator A5083264968 @default.
- W2135928749 date "2001-01-01" @default.
- W2135928749 modified "2023-10-15" @default.
- W2135928749 title "Nucleus raphé obscurus modulates hypoglossal output of neonatal rat in vitro transverse brain stem slices" @default.
- W2135928749 cites W1484357334 @default.
- W2135928749 cites W1560498709 @default.
- W2135928749 cites W1750942102 @default.
- W2135928749 cites W1800484072 @default.
- W2135928749 cites W1816316326 @default.
- W2135928749 cites W1828538530 @default.
- W2135928749 cites W1901761516 @default.
- W2135928749 cites W1922287817 @default.
- W2135928749 cites W1971288017 @default.
- W2135928749 cites W1972745541 @default.
- W2135928749 cites W1973809761 @default.
- W2135928749 cites W1974299769 @default.
- W2135928749 cites W1975049267 @default.
- W2135928749 cites W1977037306 @default.
- W2135928749 cites W1979638483 @default.
- W2135928749 cites W1991627377 @default.
- W2135928749 cites W1994616611 @default.
- W2135928749 cites W1994695342 @default.
- W2135928749 cites W2000744528 @default.
- W2135928749 cites W2001138290 @default.
- W2135928749 cites W2001167698 @default.
- W2135928749 cites W2007632407 @default.
- W2135928749 cites W2018319177 @default.
- W2135928749 cites W2019911608 @default.
- W2135928749 cites W2021110549 @default.
- W2135928749 cites W2025461949 @default.
- W2135928749 cites W2025747294 @default.
- W2135928749 cites W2029182453 @default.
- W2135928749 cites W2029338036 @default.
- W2135928749 cites W2032601445 @default.
- W2135928749 cites W2035916726 @default.
- W2135928749 cites W2037688283 @default.
- W2135928749 cites W2041460581 @default.
- W2135928749 cites W2044280082 @default.
- W2135928749 cites W2061162469 @default.
- W2135928749 cites W2062426538 @default.
- W2135928749 cites W2068422717 @default.
- W2135928749 cites W2069048858 @default.
- W2135928749 cites W2077904893 @default.
- W2135928749 cites W2079279101 @default.
- W2135928749 cites W2082706061 @default.
- W2135928749 cites W2086246680 @default.
- W2135928749 cites W2087176838 @default.
- W2135928749 cites W2094699087 @default.
- W2135928749 cites W2095238834 @default.
- W2135928749 cites W2220903811 @default.
- W2135928749 cites W2233793390 @default.
- W2135928749 cites W2234934158 @default.
- W2135928749 cites W2282341296 @default.
- W2135928749 cites W2401175449 @default.
- W2135928749 cites W2403019643 @default.
- W2135928749 cites W2414473429 @default.
- W2135928749 doi "https://doi.org/10.1152/jappl.2001.90.1.269" @default.
- W2135928749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11133919" @default.
- W2135928749 hasPublicationYear "2001" @default.
- W2135928749 type Work @default.
- W2135928749 sameAs 2135928749 @default.
- W2135928749 citedByCount "34" @default.
- W2135928749 countsByYear W21359287492012 @default.
- W2135928749 countsByYear W21359287492013 @default.
- W2135928749 countsByYear W21359287492014 @default.
- W2135928749 countsByYear W21359287492015 @default.
- W2135928749 countsByYear W21359287492017 @default.
- W2135928749 countsByYear W21359287492022 @default.
- W2135928749 countsByYear W21359287492023 @default.
- W2135928749 crossrefType "journal-article" @default.
- W2135928749 hasAuthorship W2135928749A5008490043 @default.
- W2135928749 hasAuthorship W2135928749A5019352493 @default.
- W2135928749 hasAuthorship W2135928749A5083264968 @default.
- W2135928749 hasConcept C105702510 @default.
- W2135928749 hasConcept C12554922 @default.
- W2135928749 hasConcept C126322002 @default.
- W2135928749 hasConcept C134018914 @default.
- W2135928749 hasConcept C142724271 @default.
- W2135928749 hasConcept C169760540 @default.
- W2135928749 hasConcept C170493617 @default.
- W2135928749 hasConcept C185592680 @default.
- W2135928749 hasConcept C195221683 @default.
- W2135928749 hasConcept C24998067 @default.
- W2135928749 hasConcept C2775864247 @default.
- W2135928749 hasConcept C2776108384 @default.
- W2135928749 hasConcept C2777615928 @default.
- W2135928749 hasConcept C2778110749 @default.
- W2135928749 hasConcept C2779209236 @default.
- W2135928749 hasConcept C2779744641 @default.
- W2135928749 hasConcept C37000724 @default.
- W2135928749 hasConcept C529278444 @default.
- W2135928749 hasConcept C55493867 @default.
- W2135928749 hasConcept C61174792 @default.
- W2135928749 hasConcept C71924100 @default.