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• W2135934842 endingPage "164" @default.
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• W2135934842 abstract "Cementum extracellular matrix is similar to other mineralized tissues; however, this unique tissue contains molecules only present in cementum. A cDNA of these molecules, cementum attachment protein (hrPTPLa/CAP) was cloned and expressed in a prokaryotic system. This molecule is an alternative splicing of protein tyrosine phosphatase-like A (PTPLa). In this study, we wanted to determine the structural and functional characteristics of this protein. Our results indicate that hrPTPLa/CAP contains a 43.2% α-helix, 8.9% β-sheet, 2% β-turn and 45.9% random coil secondary structure. Dynamic light scattering shows that this molecule has a size distribution of 4.8 nm and aggregates as an estimated mass of 137 kDa species. AFM characterization and FE-SEM studies indicate that this protein self-assembles into nanospheres with sizes ranging from 7.0 to 27 nm in diameter. Functional studies demonstrate that hrPTPLa/CAP promotes hydroxyapatite crystal nucleation: EDS analysis revealed that hrPTPLa/CAP-induced crystals had a 1.59 ± 0.06 Ca/P ratio. Further confirmation with MicroRaman spectrometry and TEM confirm the presence of hydroxyapatite. In vivo studies using critical-size defects in rat cranium showed that hrPTPLa/CAP promoted 73% ± 2.19% and 87% ± 1.97% new bone formation at 4 and 8 weeks respectively. Although originally identified in cementum, PTPLa/CAP is very effective at inducing bone repair and healing and therefore this novel molecule has a great potential to be used for mineralized tissue bioengineering and tissue regeneration." @default.
• W2135934842 created "2016-06-24" @default.
• W2135934842 creator A5000576238 @default.
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• W2135934842 date "2014-12-01" @default.
• W2135934842 modified "2023-10-03" @default.
• W2135934842 title "Human recombinant cementum attachment protein (hrPTPLa/CAP) promotes hydroxyapatite crystal formation in vitro and bone healing in vivo" @default.
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• W2135934842 cites W1987870530 @default.
• W2135934842 cites W1989337138 @default.
• W2135934842 cites W1992152880 @default.
• W2135934842 cites W1993752813 @default.
• W2135934842 cites W1997530993 @default.
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• W2135934842 cites W2031066958 @default.
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• W2135934842 doi "https://doi.org/10.1016/j.bone.2014.09.014" @default.
• W2135934842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25263524" @default.
• W2135934842 hasPublicationYear "2014" @default.
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