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- W2135936100 abstract "Objective: To investigate the arrangement of chromosomes within pronuclei-stage mouse zygotes.Design: In vitro study.Setting: Academic medical center.Patient(s): None.Intervention(s): None.Main Outcome Measure(s): Location of major α-satellite DNA, centromeres, and telomeres, and relative location of chromosomes.Result(s): Chromosomes appeared to be oriented inward by centromeres and to be interconnected by major α-satellite DNA, which appeared to be the sole DNA component of the nucleoli. This chromosomal arrangement persisted throughout interphase. Chromosomal painting failed to identify chromosomal ordering within pronuclei.Conclusion(s): Pronuclear nucleoli are represented by α-satellite sequences of interconnecting chromosomes that hold all chromosomes together during interphase. Chromosomes within the pronucleus are randomly positioned relative to each other." @default.
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- W2135936100 date "2000-02-01" @default.
- W2135936100 modified "2023-09-29" @default.
- W2135936100 title "Nucleoli in a pronuclei-stage mouse embryo are represented by major satellite DNA of interconnecting chromosomes" @default.
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- W2135936100 doi "https://doi.org/10.1016/s0015-0282(99)00491-4" @default.
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