FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135942209> ?p ?o ?g. }

• W2135942209 endingPage "5066" @default.
• W2135942209 startingPage "5057" @default.
• W2135942209 abstract "The DNA of patients taking immunosuppressive and anti-inflammatory thiopurines contains 6-thioguanine (6-TG) and their skin is hypersensitive to ultraviolet A (UVA) radiation. DNA 6-TG absorbs UVA and generates reactive oxygen species that damage DNA and proteins. Here, we show that the DNA damage includes covalent DNA-protein crosslinks. An oligonucleotide containing a single 6-TG is photochemically crosslinked to cysteine-containing oligopeptides by low doses of UVA. Crosslinking is significantly more efficient if guanine sulphonate (G(SO3))--an oxidized 6-TG and a previously identified UVA photoproduct--replaces 6-TG, suggesting that G(SO3) is an important reaction intermediate. Crosslinking occurs via oligopeptide sulphydryl and free amino groups. The oligonucleotide-oligopeptide adducts are heat stable but are partially reversed by reducing treatments. UVA irradiation of human cells containing DNA 6-TG induces extensive heat- and reducing agent-resistant covalent DNA-protein crosslinks and diminishes the recovery of some DNA repair and replication proteins from nuclear extracts. DNA-protein crosslinked material has an altered buoyant density and can be purified by banding in cesium chloride (CsCl) gradients. PCNA, the MSH2 mismatch repair protein and the XPA nucleotide excision repair (NER) factor are among the proteins detectable in the DNA-crosslinked material. These findings suggest that the 6-TG/UVA combination might compromise DNA repair by sequestering essential proteins." @default.
• W2135942209 created "2016-06-24" @default.
• W2135942209 creator A5018896194 @default.
• W2135942209 creator A5035270156 @default.
• W2135942209 creator A5042569509 @default.
• W2135942209 creator A5088212132 @default.
• W2135942209 date "2011-03-11" @default.
• W2135942209 modified "2023-09-28" @default.
• W2135942209 title "Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA" @default.
• W2135942209 cites W1968240894 @default.
• W2135942209 cites W1968848232 @default.
• W2135942209 cites W1972484974 @default.
• W2135942209 cites W1998969339 @default.
• W2135942209 cites W2007030143 @default.
• W2135942209 cites W2020643908 @default.
• W2135942209 cites W2020815084 @default.
• W2135942209 cites W2021814997 @default.
• W2135942209 cites W2030879575 @default.
• W2135942209 cites W2042931953 @default.
• W2135942209 cites W2061414242 @default.
• W2135942209 cites W2067595418 @default.
• W2135942209 cites W2072173165 @default.
• W2135942209 cites W2074206760 @default.
• W2135942209 cites W2078319055 @default.
• W2135942209 cites W2082015504 @default.
• W2135942209 cites W2084622414 @default.
• W2135942209 cites W2087624153 @default.
• W2135942209 cites W2114624818 @default.
• W2135942209 cites W2116165311 @default.
• W2135942209 cites W2119665774 @default.
• W2135942209 cites W2133408276 @default.
• W2135942209 doi "https://doi.org/10.1093/nar/gkr112" @default.
• W2135942209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3130278" @default.
• W2135942209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21398635" @default.
• W2135942209 hasPublicationYear "2011" @default.
• W2135942209 type Work @default.
• W2135942209 sameAs 2135942209 @default.
• W2135942209 citedByCount "41" @default.
• W2135942209 countsByYear W21359422092012 @default.
• W2135942209 countsByYear W21359422092013 @default.
• W2135942209 countsByYear W21359422092014 @default.
• W2135942209 countsByYear W21359422092015 @default.
• W2135942209 countsByYear W21359422092016 @default.
• W2135942209 countsByYear W21359422092017 @default.
• W2135942209 countsByYear W21359422092018 @default.
• W2135942209 countsByYear W21359422092019 @default.
• W2135942209 countsByYear W21359422092021 @default.
• W2135942209 countsByYear W21359422092022 @default.
• W2135942209 countsByYear W21359422092023 @default.
• W2135942209 crossrefType "journal-article" @default.
• W2135942209 hasAuthorship W2135942209A5018896194 @default.
• W2135942209 hasAuthorship W2135942209A5035270156 @default.
• W2135942209 hasAuthorship W2135942209A5042569509 @default.
• W2135942209 hasAuthorship W2135942209A5088212132 @default.
• W2135942209 hasBestOaLocation W21359422092 @default.
• W2135942209 hasConcept C104317684 @default.
• W2135942209 hasConcept C104451858 @default.
• W2135942209 hasConcept C113271649 @default.
• W2135942209 hasConcept C129312508 @default.
• W2135942209 hasConcept C134935766 @default.
• W2135942209 hasConcept C143425029 @default.
• W2135942209 hasConcept C153911025 @default.
• W2135942209 hasConcept C2778301229 @default.
• W2135942209 hasConcept C512185932 @default.
• W2135942209 hasConcept C552990157 @default.
• W2135942209 hasConcept C55493867 @default.
• W2135942209 hasConcept C73573662 @default.
• W2135942209 hasConcept C86339819 @default.
• W2135942209 hasConcept C86803240 @default.
• W2135942209 hasConcept C94966510 @default.
• W2135942209 hasConceptScore W2135942209C104317684 @default.
• W2135942209 hasConceptScore W2135942209C104451858 @default.
• W2135942209 hasConceptScore W2135942209C113271649 @default.
• W2135942209 hasConceptScore W2135942209C129312508 @default.
• W2135942209 hasConceptScore W2135942209C134935766 @default.
• W2135942209 hasConceptScore W2135942209C143425029 @default.
• W2135942209 hasConceptScore W2135942209C153911025 @default.
• W2135942209 hasConceptScore W2135942209C2778301229 @default.
• W2135942209 hasConceptScore W2135942209C512185932 @default.
• W2135942209 hasConceptScore W2135942209C552990157 @default.
• W2135942209 hasConceptScore W2135942209C55493867 @default.
• W2135942209 hasConceptScore W2135942209C73573662 @default.
• W2135942209 hasConceptScore W2135942209C86339819 @default.
• W2135942209 hasConceptScore W2135942209C86803240 @default.
• W2135942209 hasConceptScore W2135942209C94966510 @default.
• W2135942209 hasIssue "12" @default.
• W2135942209 hasLocation W21359422091 @default.
• W2135942209 hasLocation W21359422092 @default.
• W2135942209 hasLocation W21359422093 @default.
• W2135942209 hasLocation W21359422094 @default.
• W2135942209 hasOpenAccess W2135942209 @default.
• W2135942209 hasPrimaryLocation W21359422091 @default.
• W2135942209 hasRelatedWork W1555107814 @default.
• W2135942209 hasRelatedWork W1746630368 @default.
• W2135942209 hasRelatedWork W2005621507 @default.
• W2135942209 hasRelatedWork W2108192168 @default.
• W2135942209 hasRelatedWork W2122753398 @default.
• W2135942209 hasRelatedWork W2123456626 @default.

• next