FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135943189> ?p ?o ?g. }

• W2135943189 abstract "The relationship between cognitive and functional impairment in AD is not well characterized. Recent analyses suggest that cognitive decline precedes and predicts functional declines throughout the progression of AD. Data from patients with mild AD (Mini-Mental State Examination score 20 to 26) were pooled from two multicenter, double-blind, Phase 3 solanezumab studies (EXPEDITION and EXPEDITION2) and separately for two semagacestat studies (IDENTITY and IDENTITY2). Cognitive and functional outcome measures were assessed at baseline and 6 post-baseline time points every 3 months for 18 months using the AD Assessment Scale-Cognitive subscale (ADAS-Cog 14) and the AD Cooperative Study-Activities of Daily Living instrumental subscale (ADCS-iADL). Auto-regressive cross-lagged panel analyses were used to evaluate the relationships between cognitive and functional impairment over time, and potential causal relationships between them. Overall model fit was assessed using Comparative Fit Index (CFI) and Root Mean Square Error of Approximation (RMSEA). A model with CFI of 0.9 or greater and RMSEA of 0.06 or less is considered acceptable. In EXPEDITION/EXPEDITION2, the results from the cross-lagged panel analyses demonstrated that cognitive impairment significantly predicted future functional impairment in 5 out of 6 time points (CFI=0.993, RMSEA=0.045). Results showed that functional scores predicted cognitive outcomes in only 1 out of 6 time points when the same analyses were performed to test the opposite hypothesis. The data from IDENTITY/IDENTITY2 were more limited due to early termination of the trials and a small sample size, but the analyses still yielded consistent results that cognition predicted subsequent function (CFI=0.998, RMSEA=0.025). The analyses from all 4 clinical trials indicated that cognitive decline precedes and predicts subsequent functional decline. These findings are consistent with previously proposed hypotheses and with recent publications using similar methodologies. Cognition, in this research measured by ADAS-Cog 14, can be used as a predictor for future functional impairments in mild AD." @default.
• W2135943189 created "2016-06-24" @default.
• W2135943189 creator A5001330348 @default.
• W2135943189 creator A5034225628 @default.
• W2135943189 creator A5037912275 @default.
• W2135943189 creator A5041035865 @default.
• W2135943189 creator A5060487287 @default.
• W2135943189 creator A5063618224 @default.
• W2135943189 creator A5077626458 @default.
• W2135943189 creator A5079086758 @default.
• W2135943189 creator A5080609944 @default.
• W2135943189 creator A5082728252 @default.
• W2135943189 creator A5085051732 @default.
• W2135943189 date "2014-07-01" @default.
• W2135943189 modified "2023-09-27" @default.
• W2135943189 title "P2-390: COGNITION IMPAIRMENT PRECEDES AND PREDICTS FUNCTIONAL IMPAIRMENT IN MILD ALZHIEMER's DISEASE" @default.
• W2135943189 doi "https://doi.org/10.1016/j.jalz.2014.05.1070" @default.
• W2135943189 hasPublicationYear "2014" @default.
• W2135943189 type Work @default.
• W2135943189 sameAs 2135943189 @default.
• W2135943189 citedByCount "0" @default.
• W2135943189 crossrefType "journal-article" @default.
• W2135943189 hasAuthorship W2135943189A5001330348 @default.
• W2135943189 hasAuthorship W2135943189A5034225628 @default.
• W2135943189 hasAuthorship W2135943189A5037912275 @default.
• W2135943189 hasAuthorship W2135943189A5041035865 @default.
• W2135943189 hasAuthorship W2135943189A5060487287 @default.
• W2135943189 hasAuthorship W2135943189A5063618224 @default.
• W2135943189 hasAuthorship W2135943189A5077626458 @default.
• W2135943189 hasAuthorship W2135943189A5079086758 @default.
• W2135943189 hasAuthorship W2135943189A5080609944 @default.
• W2135943189 hasAuthorship W2135943189A5082728252 @default.
• W2135943189 hasAuthorship W2135943189A5085051732 @default.
• W2135943189 hasConcept C105795698 @default.
• W2135943189 hasConcept C118552586 @default.
• W2135943189 hasConcept C138496976 @default.
• W2135943189 hasConcept C15744967 @default.
• W2135943189 hasConcept C169900460 @default.
• W2135943189 hasConcept C2984915365 @default.
• W2135943189 hasConcept C33923547 @default.
• W2135943189 hasConcept C548259974 @default.
• W2135943189 hasConcept C70410870 @default.
• W2135943189 hasConcept C71104824 @default.
• W2135943189 hasConcept C71924100 @default.
• W2135943189 hasConceptScore W2135943189C105795698 @default.
• W2135943189 hasConceptScore W2135943189C118552586 @default.
• W2135943189 hasConceptScore W2135943189C138496976 @default.
• W2135943189 hasConceptScore W2135943189C15744967 @default.
• W2135943189 hasConceptScore W2135943189C169900460 @default.
• W2135943189 hasConceptScore W2135943189C2984915365 @default.
• W2135943189 hasConceptScore W2135943189C33923547 @default.
• W2135943189 hasConceptScore W2135943189C548259974 @default.
• W2135943189 hasConceptScore W2135943189C70410870 @default.
• W2135943189 hasConceptScore W2135943189C71104824 @default.
• W2135943189 hasConceptScore W2135943189C71924100 @default.
• W2135943189 hasIssue "4S_Part_17" @default.
• W2135943189 hasLocation W21359431891 @default.
• W2135943189 hasOpenAccess W2135943189 @default.
• W2135943189 hasPrimaryLocation W21359431891 @default.
• W2135943189 hasRelatedWork W2014659263 @default.
• W2135943189 hasRelatedWork W2016713905 @default.
• W2135943189 hasRelatedWork W2030000401 @default.
• W2135943189 hasRelatedWork W2052460212 @default.
• W2135943189 hasRelatedWork W2064484569 @default.
• W2135943189 hasRelatedWork W2157241338 @default.
• W2135943189 hasRelatedWork W2334446790 @default.
• W2135943189 hasRelatedWork W2377276789 @default.
• W2135943189 hasRelatedWork W2530873040 @default.
• W2135943189 hasRelatedWork W2902027532 @default.
• W2135943189 hasVolume "10" @default.
• W2135943189 isParatext "false" @default.
• W2135943189 isRetracted "false" @default.
• W2135943189 magId "2135943189" @default.
• W2135943189 workType "article" @default.