FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2135970036> ?p ?o ?g. }

• W2135970036 abstract "Artemisinin-combination therapy is a highly effective treatment for uncomplicated falciparum malaria but parasite recrudescence has been commonly reported following artemisinin (ART) monotherapy. The dormancy recovery hypothesis has been proposed to explain this phenomenon, which is different from the slower parasite clearance times reported as the first evidence of the development of ART resistance.In this study, an existing P. falciparum infection model is modified to incorporate the hypothesis of dormancy. Published in vitro data describing the characteristics of dormant parasites is used to explore whether dormancy alone could be responsible for the high recrudescence rates observed in field studies using monotherapy. Several treatment regimens and dormancy rates were simulated to investigate the rate of clinical and parasitological failure following treatment.The model output indicates that following a single treatment with ART parasitological and clinical failures occur in up to 77% and 67% of simulations, respectively. These rates rapidly decline with repeated treatment and are sensitive to the assumed dormancy rate. The simulated parasitological and clinical treatment failure rates after 3 and 7 days of treatment are comparable to those reported from several field trials.Although further studies are required to confirm dormancy in vivo, this theoretical study adds support for the hypothesis, highlighting the potential role of this parasite sub-population in treatment failure following monotherapy and reinforcing the importance of using ART in combination with other anti-malarials." @default.
• W2135970036 created "2016-06-24" @default.
• W2135970036 creator A5039014826 @default.
• W2135970036 creator A5049503823 @default.
• W2135970036 creator A5068779570 @default.
• W2135970036 creator A5080098306 @default.
• W2135970036 creator A5082171943 @default.
• W2135970036 date "2011-03-08" @default.
• W2135970036 modified "2023-10-15" @default.
• W2135970036 title "Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure" @default.
• W2135970036 cites W1927214849 @default.
• W2135970036 cites W1963865286 @default.
• W2135970036 cites W1964590401 @default.
• W2135970036 cites W1991072114 @default.
• W2135970036 cites W1999692874 @default.
• W2135970036 cites W2016977143 @default.
• W2135970036 cites W2023783944 @default.
• W2135970036 cites W2028844917 @default.
• W2135970036 cites W2076183255 @default.
• W2135970036 cites W2091016659 @default.
• W2135970036 cites W2102343384 @default.
• W2135970036 cites W2122534122 @default.
• W2135970036 cites W2128208738 @default.
• W2135970036 cites W2137529385 @default.
• W2135970036 cites W2147982765 @default.
• W2135970036 cites W2161311583 @default.
• W2135970036 cites W2170682688 @default.
• W2135970036 cites W2181657564 @default.
• W2135970036 cites W2395812409 @default.
• W2135970036 doi "https://doi.org/10.1186/1475-2875-10-56" @default.
• W2135970036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3060839" @default.
• W2135970036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21385409" @default.
• W2135970036 hasPublicationYear "2011" @default.
• W2135970036 type Work @default.
• W2135970036 sameAs 2135970036 @default.
• W2135970036 citedByCount "88" @default.
• W2135970036 countsByYear W21359700362012 @default.
• W2135970036 countsByYear W21359700362013 @default.
• W2135970036 countsByYear W21359700362014 @default.
• W2135970036 countsByYear W21359700362015 @default.
• W2135970036 countsByYear W21359700362016 @default.
• W2135970036 countsByYear W21359700362017 @default.
• W2135970036 countsByYear W21359700362018 @default.
• W2135970036 countsByYear W21359700362019 @default.
• W2135970036 countsByYear W21359700362020 @default.
• W2135970036 countsByYear W21359700362021 @default.
• W2135970036 countsByYear W21359700362022 @default.
• W2135970036 countsByYear W21359700362023 @default.
• W2135970036 crossrefType "journal-article" @default.
• W2135970036 hasAuthorship W2135970036A5039014826 @default.
• W2135970036 hasAuthorship W2135970036A5049503823 @default.
• W2135970036 hasAuthorship W2135970036A5068779570 @default.
• W2135970036 hasAuthorship W2135970036A5080098306 @default.
• W2135970036 hasAuthorship W2135970036A5082171943 @default.
• W2135970036 hasBestOaLocation W21359700361 @default.
• W2135970036 hasConcept C100701293 @default.
• W2135970036 hasConcept C126322002 @default.
• W2135970036 hasConcept C136764020 @default.
• W2135970036 hasConcept C203014093 @default.
• W2135970036 hasConcept C2776120307 @default.
• W2135970036 hasConcept C2776999253 @default.
• W2135970036 hasConcept C2778048844 @default.
• W2135970036 hasConcept C2778371730 @default.
• W2135970036 hasConcept C2908647359 @default.
• W2135970036 hasConcept C3527866 @default.
• W2135970036 hasConcept C41008148 @default.
• W2135970036 hasConcept C535046627 @default.
• W2135970036 hasConcept C59822182 @default.
• W2135970036 hasConcept C71924100 @default.
• W2135970036 hasConcept C71928629 @default.
• W2135970036 hasConcept C86803240 @default.
• W2135970036 hasConcept C98274493 @default.
• W2135970036 hasConcept C99454951 @default.
• W2135970036 hasConceptScore W2135970036C100701293 @default.
• W2135970036 hasConceptScore W2135970036C126322002 @default.
• W2135970036 hasConceptScore W2135970036C136764020 @default.
• W2135970036 hasConceptScore W2135970036C203014093 @default.
• W2135970036 hasConceptScore W2135970036C2776120307 @default.
• W2135970036 hasConceptScore W2135970036C2776999253 @default.
• W2135970036 hasConceptScore W2135970036C2778048844 @default.
• W2135970036 hasConceptScore W2135970036C2778371730 @default.
• W2135970036 hasConceptScore W2135970036C2908647359 @default.
• W2135970036 hasConceptScore W2135970036C3527866 @default.
• W2135970036 hasConceptScore W2135970036C41008148 @default.
• W2135970036 hasConceptScore W2135970036C535046627 @default.
• W2135970036 hasConceptScore W2135970036C59822182 @default.
• W2135970036 hasConceptScore W2135970036C71924100 @default.
• W2135970036 hasConceptScore W2135970036C71928629 @default.
• W2135970036 hasConceptScore W2135970036C86803240 @default.
• W2135970036 hasConceptScore W2135970036C98274493 @default.
• W2135970036 hasConceptScore W2135970036C99454951 @default.
• W2135970036 hasIssue "1" @default.
• W2135970036 hasLocation W21359700361 @default.
• W2135970036 hasLocation W21359700362 @default.
• W2135970036 hasLocation W21359700363 @default.
• W2135970036 hasLocation W21359700364 @default.
• W2135970036 hasLocation W21359700365 @default.
• W2135970036 hasOpenAccess W2135970036 @default.
• W2135970036 hasPrimaryLocation W21359700361 @default.
• W2135970036 hasRelatedWork W1970678915 @default.

• next