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• W2135971237 abstract "Polyarthritis and cardiac lesions have been observed in the adult rat with homologous disease. Changes in the lymphoid tissue and kidney have also been noted. A migratory polyarthritis occurred in over half of the affected animals, and cardiac involvement of varying intensity was present in all. Histologically, the arthritis was characterized by a mononuclear synovial inflammatory reaction. In the heart, the valves and myocardium demonstrated a similar type of response. Cultures of involved joints and hearts for pyogens and pleuropneumonia-like organisms were negative. The lymphoid tissues showed progressive changes in three stages: (a) disappearance of follicles; (b) increase in plasma-like cells and histiocytes; and (c) fibrosis. The second stage tended to coincide with the development of the polyarthritis. The kidney showed mild interstitial mononuclear infiltration. The pathologic changes described appear to be a consequence of reaction between foreign immunologically competent cells and host antigens, but the possibility that these lesions represent a response to antigens derived from unknown infectious agents is, however, not ruled out." @default.
• W2135971237 created "2016-06-24" @default.
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• W2135971237 date "1965-10-01" @default.
• W2135971237 modified "2023-09-27" @default.
• W2135971237 title "HOMOLOGOUS DISEASE IN THE ADULT RAT, A MODEL FOR AUTOIMMUNE DISEASE" @default.
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• W2135971237 doi "https://doi.org/10.1084/jem.122.4.681" @default.
• W2135971237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2138092" @default.
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• W2135971237 hasPublicationYear "1965" @default.
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