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- W2135991755 abstract "Single injections of 100 μg of 5-fluorouracil (5-FU) containing 1.25 μc of [2-14C]5-FU were made into the yolk sac of 4-day chick embryos. Greater amounts of label were incorporated into DNA than into RNA extracts. The rate of accumulation of protein per embryo was lowered by 5-FU to a somewhat greater extent than was either DNA or RNA. Chromatography of TCA-soluble fraction from 5-day embryos indicated presence of 5-FU and two peaks of unidentified heavier molecules derived from 5-FU. Thus the selective depression of protein accumulation and the progressive labeling of DNA from 5-FU indicate a wider spectrum of metabolic effects in chick embryos than might be expected from the reports of 5-FU in the literature. These data suggest that 5-FU may act as a teratogen by one or more routes other than as an analogue of an RNA precursor." @default.
- W2135991755 created "2016-06-24" @default.
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- W2135991755 date "1974-08-01" @default.
- W2135991755 modified "2023-09-27" @default.
- W2135991755 title "5-FU in chick embryos as a source of label for DNA and a depressant of protein synthesis" @default.
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- W2135991755 doi "https://doi.org/10.1002/tera.1420100107" @default.
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