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- W2135994759 endingPage "1713" @default.
- W2135994759 startingPage "1695" @default.
- W2135994759 abstract "Transformed cells, characterised by inappropriate cell proliferation, do not necessarily lose the capacity to undergo growth arrest under certain stimuli. DNA, genetic information, is packaged in chromatin proteins, for example, histones. The structure of chromatin may be altered by post-translational modifications (e.g., acetylation, phosphorylation, methylation and ubiquitylation) which play a role in regulating gene expression. Two groups of enzymes, histone deacetylases (HDACs) and acetyl transferases, determine the acetylation status of histones. This review focuses on compounds that inhibit HDAC activity. These agents have been shown to be active in vitro and in vivo in causing cancer cell growth arrest, differentiation and/or apoptosis. Several HDAC inhibitors are currently in clinical trials as anticancer agents and, in particular, hydroxamic acid-based HDAC inhibitors have shown activity against cancers at well-tolerated doses." @default.
- W2135994759 created "2016-06-24" @default.
- W2135994759 creator A5002126535 @default.
- W2135994759 creator A5078159824 @default.
- W2135994759 creator A5090355173 @default.
- W2135994759 date "2002-12-01" @default.
- W2135994759 modified "2023-10-18" @default.
- W2135994759 title "Histone deacetylase inhibitors: from target to clinical trials" @default.
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