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- W2136010626 abstract "Levosimendan is an inodilator indicated for the short-term treatment of acutely decompensated severe chronic heart failure, and in situations where conventional therapy is not considered adequate. The principal pharmacological effects of levosimendan are (a) increased cardiac contractility by calcium sensitisation of troponin C, (b) vasodilation, and (c) cardioprotection. These last two effects are related to the opening of sarcolemmal and mitochondrial potassium-ATP channels, respectively. Data from clinical trials indicate that levosimendan improves haemodynamics with no attendant significant increase in cardiac oxygen consumption and relieves symptoms of acute heart failure; these effects are not impaired or attenuated by the concomitant use of beta-blockers. Levosimendan also has favourable effects on neurohormone levels in heart failure patients. Levosimendan is generally well tolerated in acute heart failure patients: the most common adverse events encountered in this setting are hypotension, headache, atrial fibrillation, hypokalaemia and tachycardia. Levosimendan has also been studied in other therapeutic applications, particularly cardiac surgery - in which it has shown a range of beneficial haemodynamic and cardioprotective effects, and a favourable influence on clinical outcomes - and has been evaluated in repetitive dosing protocols in patients with advanced chronic heart failure. Levosimendan has shown preliminary positive effects in a range of conditions requiring inotropic support, including right ventricular failure, cardiogenic shock, septic shock, and Takotsubo cardiomyopathy." @default.
- W2136010626 created "2016-06-24" @default.
- W2136010626 creator A5027601842 @default.
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- W2136010626 creator A5061166515 @default.
- W2136010626 creator A5065380088 @default.
- W2136010626 date "2013-01-01" @default.
- W2136010626 modified "2023-09-29" @default.
- W2136010626 title "Levosimendan: current data, clinical use and future development." @default.
- W2136010626 cites W1506887995 @default.
- W2136010626 cites W1556535974 @default.
- W2136010626 cites W1580601226 @default.
- W2136010626 cites W1595801403 @default.
- W2136010626 cites W1748374584 @default.
- W2136010626 cites W1930352112 @default.
- W2136010626 cites W1969138599 @default.
- W2136010626 cites W1975641106 @default.
- W2136010626 cites W1981985639 @default.
- W2136010626 cites W1983305832 @default.
- W2136010626 cites W1983477070 @default.
- W2136010626 cites W1987952896 @default.
- W2136010626 cites W1991814810 @default.
- W2136010626 cites W1992536611 @default.
- W2136010626 cites W1995122464 @default.
- W2136010626 cites W1997155620 @default.
- W2136010626 cites W1997993335 @default.
- W2136010626 cites W1998488091 @default.
- W2136010626 cites W2000056139 @default.
- W2136010626 cites W2000876750 @default.
- W2136010626 cites W2004341877 @default.
- W2136010626 cites W2005717288 @default.
- W2136010626 cites W2007344779 @default.
- W2136010626 cites W2010699540 @default.
- W2136010626 cites W2011160790 @default.
- W2136010626 cites W2012864937 @default.
- W2136010626 cites W2013687346 @default.
- W2136010626 cites W2015507882 @default.
- W2136010626 cites W2017583766 @default.
- W2136010626 cites W2019161030 @default.
- W2136010626 cites W2023005794 @default.
- W2136010626 cites W2027898894 @default.
- W2136010626 cites W2027960752 @default.
- W2136010626 cites W2027999171 @default.
- W2136010626 cites W2029377396 @default.
- W2136010626 cites W2031514364 @default.
- W2136010626 cites W2032118462 @default.
- W2136010626 cites W2033225260 @default.
- W2136010626 cites W2034011395 @default.
- W2136010626 cites W2036330627 @default.
- W2136010626 cites W2038229351 @default.
- W2136010626 cites W2039392276 @default.
- W2136010626 cites W2040624527 @default.
- W2136010626 cites W2041875434 @default.
- W2136010626 cites W2045290851 @default.
- W2136010626 cites W2046724909 @default.
- W2136010626 cites W2048959653 @default.
- W2136010626 cites W2049536761 @default.
- W2136010626 cites W2050077505 @default.
- W2136010626 cites W2053409291 @default.
- W2136010626 cites W2053980793 @default.
- W2136010626 cites W2054938569 @default.
- W2136010626 cites W2056646492 @default.
- W2136010626 cites W2058542276 @default.
- W2136010626 cites W2059752992 @default.
- W2136010626 cites W2060904229 @default.
- W2136010626 cites W2061463574 @default.
- W2136010626 cites W2062219104 @default.
- W2136010626 cites W2063940938 @default.
- W2136010626 cites W2064927551 @default.
- W2136010626 cites W2066118369 @default.
- W2136010626 cites W2068616973 @default.
- W2136010626 cites W2069745742 @default.
- W2136010626 cites W2071156135 @default.
- W2136010626 cites W2071297987 @default.
- W2136010626 cites W2072650593 @default.
- W2136010626 cites W2074187473 @default.
- W2136010626 cites W2078176071 @default.
- W2136010626 cites W2078213367 @default.
- W2136010626 cites W2084482269 @default.
- W2136010626 cites W2085028768 @default.
- W2136010626 cites W2087553025 @default.
- W2136010626 cites W2098634559 @default.
- W2136010626 cites W2098740917 @default.
- W2136010626 cites W2100558276 @default.
- W2136010626 cites W2101544705 @default.
- W2136010626 cites W2101809775 @default.
- W2136010626 cites W2102307678 @default.
- W2136010626 cites W2104724345 @default.
- W2136010626 cites W2104996682 @default.
- W2136010626 cites W2106703370 @default.
- W2136010626 cites W2109712401 @default.
- W2136010626 cites W2112781257 @default.
- W2136010626 cites W2113439927 @default.
- W2136010626 cites W2114759921 @default.
- W2136010626 cites W2117483856 @default.