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• W2136021956 abstract "Some trypanosomatids harbor a symbiotic bacterium, which maintains a close association with the host, constituting an excellent model to study organelle origin and cellular evolution. Molecular data show that all endosymbiontharboring trypanosomatids are grouped together in a single phylogenetic branch. According to rRNA sequences, symbionts of different species are similar, being classified in the ß division of Proteobacteria, thus suggesting that a single evolutionary event gave rise to the symbiosis in the Trypanosomatidae family. The bacterium is enclosed by two unit membranes and presents a reduced peptidoglycan layer, which is essential for cell division and morphological maintenance. Regarding the protein composition, the number of intramembrane particles in the endosymbiont envelope is similar to that described for Gram-negative bacteria. Lipid analyses of purified endosymbionts show absence of sterols and indicate phosphatidylcholine as a major component of the envelope, as described in other intracellular bacteria. The presence of the endosymbiont is associated with distinct ultrastructural and physico-chemical alterations in the trypanosomatid and influences the protozoan interaction with the insect host and mammalian cells. Symbiont-containing trypanosomatids are able to infect and to replicate inside fibroblasts and macrophages, whose microbicidal activity was deactivated by HIV-1 infection. The symbiosis in trypanosomatids is characterized by intensive metabolic exchanges; the bacterium expresses enzymes and metabolic precursors that complete essential biosynthetic pathways of the protozoan. Conversely, the symbiont is capable of obtaining part of the required energetic molecules from the host glycosomes. Taken together data suggest that endosymbiosis in trypanosomatids represents an interesting model to study cell evolution." @default.
• W2136021956 created "2016-06-24" @default.
• W2136021956 creator A5070823338 @default.
• W2136021956 date "2010-03-15" @default.
• W2136021956 modified "2023-10-03" @default.
• W2136021956 title "Endosymbiosis in Trypanosomatids as a Model to Study Cell Evolution" @default.
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• W2136021956 doi "https://doi.org/10.2174/1874421401004010139" @default.
• W2136021956 hasPublicationYear "2010" @default.
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