FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136021981> ?p ?o ?g. }

• W2136021981 endingPage "160" @default.
• W2136021981 startingPage "152" @default.
• W2136021981 abstract "Background The association between C-reactive protein (CRP) levels and risk of cardiovascular (CV) events has been reported in several studies. However, it is unclear whether a reduction in CRP is associated with a reduction in risk of clinical events. Therefore we sought to investigate, in a meta-regression analysis of randomized studies enrolling patients treated by statins, whether changes in CRP are associated with changes in risk of CV events or overall survival. Methods Randomized trials enrolling patients treated by statins, reporting CRP at baseline and at end of follow-up, CV events [myocardial infarction (MI) and stroke], CV and all-cause mortality were selected. Results Twenty-two trials enrolling 54,213 participants were included in the analysis. Meta-analysis showed that active treatment significantly reduced risk of all-cause death by 8%, myocardial infarction by 11%, stroke by 10.3% and the composite outcome (including CV death, MI and stroke) by 8%, whereas risks of CV mortality was not significantly reduced. Meta-regression analysis revealed that reduction in CRP levels was significantly associated only with the reduction of MI, whereas no relationship was identified between changes in CRP and risk of stroke, CV and all-cause mortality, and the composite outcome. Conclusions These findings demonstrate that statin-induced changes in CRP do not correlate with major CV events apart from the risk of MI nor with overall survival in high-risk patients. These data suggest that although CRP may be a surrogate marker for coronary risk, it should not be used for predicting the effectiveness of statin therapy." @default.
• W2136021981 created "2016-06-24" @default.
• W2136021981 creator A5007555093 @default.
• W2136021981 creator A5015344056 @default.
• W2136021981 creator A5020371820 @default.
• W2136021981 creator A5043319148 @default.
• W2136021981 creator A5055832234 @default.
• W2136021981 creator A5073037854 @default.
• W2136021981 creator A5081364563 @default.
• W2136021981 creator A5084708009 @default.
• W2136021981 date "2014-11-01" @default.
• W2136021981 modified "2023-09-26" @default.
• W2136021981 title "Reduction of C-reactive protein is not associated with reduced cardiovascular risk and mortality in patients treated with statins. A meta-analysis of 22 randomized trials" @default.
• W2136021981 cites W1520348292 @default.
• W2136021981 cites W1587342213 @default.
• W2136021981 cites W1812416290 @default.
• W2136021981 cites W1937664636 @default.
• W2136021981 cites W1982392960 @default.
• W2136021981 cites W1989028689 @default.
• W2136021981 cites W1993060519 @default.
• W2136021981 cites W1994898034 @default.
• W2136021981 cites W1995187774 @default.
• W2136021981 cites W2018711158 @default.
• W2136021981 cites W2019790119 @default.
• W2136021981 cites W2022120174 @default.
• W2136021981 cites W2039420330 @default.
• W2136021981 cites W2047348709 @default.
• W2136021981 cites W2059934146 @default.
• W2136021981 cites W2064214053 @default.
• W2136021981 cites W2066061852 @default.
• W2136021981 cites W2067231723 @default.
• W2136021981 cites W2080883999 @default.
• W2136021981 cites W2102095525 @default.
• W2136021981 cites W2102899779 @default.
• W2136021981 cites W2111597641 @default.
• W2136021981 cites W2113275926 @default.
• W2136021981 cites W2118154631 @default.
• W2136021981 cites W2119475547 @default.
• W2136021981 cites W2120289695 @default.
• W2136021981 cites W2126452437 @default.
• W2136021981 cites W2127933204 @default.
• W2136021981 cites W2137983259 @default.
• W2136021981 cites W2144790234 @default.
• W2136021981 cites W2145053304 @default.
• W2136021981 cites W2147454356 @default.
• W2136021981 cites W2149991612 @default.
• W2136021981 cites W2155121555 @default.
• W2136021981 cites W2155693224 @default.
• W2136021981 cites W2157622195 @default.
• W2136021981 cites W2157823046 @default.
• W2136021981 cites W2162430779 @default.
• W2136021981 cites W2165934245 @default.
• W2136021981 cites W2167362639 @default.
• W2136021981 cites W2170521505 @default.
• W2136021981 cites W2316243284 @default.
• W2136021981 cites W2468996569 @default.
• W2136021981 cites W3021842026 @default.
• W2136021981 cites W92189825 @default.
• W2136021981 doi "https://doi.org/10.1016/j.ijcard.2014.09.028" @default.
• W2136021981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25499365" @default.
• W2136021981 hasPublicationYear "2014" @default.
• W2136021981 type Work @default.
• W2136021981 sameAs 2136021981 @default.
• W2136021981 citedByCount "7" @default.
• W2136021981 countsByYear W21360219812015 @default.
• W2136021981 countsByYear W21360219812016 @default.
• W2136021981 countsByYear W21360219812018 @default.
• W2136021981 countsByYear W21360219812020 @default.
• W2136021981 countsByYear W21360219812022 @default.
• W2136021981 crossrefType "journal-article" @default.
• W2136021981 hasAuthorship W2136021981A5007555093 @default.
• W2136021981 hasAuthorship W2136021981A5015344056 @default.
• W2136021981 hasAuthorship W2136021981A5020371820 @default.
• W2136021981 hasAuthorship W2136021981A5043319148 @default.
• W2136021981 hasAuthorship W2136021981A5055832234 @default.
• W2136021981 hasAuthorship W2136021981A5073037854 @default.
• W2136021981 hasAuthorship W2136021981A5081364563 @default.
• W2136021981 hasAuthorship W2136021981A5084708009 @default.
• W2136021981 hasConcept C126322002 @default.
• W2136021981 hasConcept C127413603 @default.
• W2136021981 hasConcept C164705383 @default.
• W2136021981 hasConcept C168563851 @default.
• W2136021981 hasConcept C2776839432 @default.
• W2136021981 hasConcept C2776914184 @default.
• W2136021981 hasConcept C2780645631 @default.
• W2136021981 hasConcept C2781195455 @default.
• W2136021981 hasConcept C500558357 @default.
• W2136021981 hasConcept C71924100 @default.
• W2136021981 hasConcept C78519656 @default.
• W2136021981 hasConcept C95190672 @default.
• W2136021981 hasConceptScore W2136021981C126322002 @default.
• W2136021981 hasConceptScore W2136021981C127413603 @default.
• W2136021981 hasConceptScore W2136021981C164705383 @default.
• W2136021981 hasConceptScore W2136021981C168563851 @default.
• W2136021981 hasConceptScore W2136021981C2776839432 @default.
• W2136021981 hasConceptScore W2136021981C2776914184 @default.
• W2136021981 hasConceptScore W2136021981C2780645631 @default.
• W2136021981 hasConceptScore W2136021981C2781195455 @default.

• next