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• W2136037415 abstract "ABSTRACT The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through pattern recognition receptors (PRR) and transduces downstream signaling to activate the host defense. Here we report that in addition to direct PAMP-PRR interactions, live Candida albicans cells can release soluble factors to actively potentiate interleukin-6 (IL-6) and IL-8 production induced in human mononuclear cells by the fungi. Although protease-activated receptor 1 (PAR1) and PAR2 ligation can moderately upregulate Toll-like receptor 4 (TLR4)-mediated IL-8 production, no effect on the C. albicans -induced cytokine was apparent. Similarly, the blockade of PAR signaling did not reverse the potentiation of cytokine production induced by soluble factors released by C. albicans . In conclusion, C. albicans releases soluble factors that potentiate cytokine release in a PAR1/2-independent manner. Thus, human PAR1 and PAR2 have a redundant role in the activation of human cells by C. albicans ." @default.
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• W2136037415 date "2010-01-01" @default.
• W2136037415 modified "2023-09-25" @default.
• W2136037415 title "<i>Candida albicans</i> Releases Soluble Factors That Potentiate Cytokine Production by Human Cells through a Protease-Activated Receptor 1- and 2-Independent Pathway" @default.
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• W2136037415 doi "https://doi.org/10.1128/iai.01041-09" @default.
• W2136037415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2798204" @default.
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