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• W2136043232 endingPage "34" @default.
• W2136043232 startingPage "23" @default.
• W2136043232 abstract "Peptide:N-glycanase (PNGase) is a de-N-glycosylating enzyme that cleaves intact N-glycans from glycoproteins/glycopeptides. The activity of the cytoplasmic PNGase in several mammalian-derived cultured cells was first reported in 1993, and 7 years later, the gene encoding the enzyme was identified in budding yeast. Although the gene—PNG1 in budding yeast and NGLY1/Ngly1 in mammalian cells—appears to be well conserved throughout eukaryotes, the biological significance of this enzyme has remained elusive until recently. However, discovery of a human genetic disorder involving the NGLY1 gene clearly indicates that this enzyme plays a critical role in human biology. This review summarizes the research history of cytoplasmic PNGase. The importance of curiosity-driven, pure ‘basic science’ will also be discussed." @default.
• W2136043232 created "2016-06-24" @default.
• W2136043232 creator A5054250942 @default.
• W2136043232 date "2014-11-13" @default.
• W2136043232 modified "2023-09-27" @default.
• W2136043232 title "The cytoplasmic peptide:N-glycanase (Ngly1)--basic science encounters a human genetic disorder" @default.
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