FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136049998> ?p ?o ?g. }

• W2136049998 endingPage "371" @default.
• W2136049998 startingPage "363" @default.
• W2136049998 abstract "Large striatal neurons are spared in caudate tissue from postmortem brain of patients with Huntington's disease (HD) and in the rat caudate lesioned with excitotoxins at short postlesion intervals. In order to determine the survival of large neurons and other effects of excitotoxicity at longer postlesion intervals the rat caudate nucleus was examined 2, 7, and 30 weeks after intrastriatal injections of the excitotoxin, quinolinic acid. The caudate nucleus diminished in size progressively up to 30 weeks postlesion due to 1) shrinkage and compacting of the lesion zone and 2) reduction in area of intact caudate, apparently due to gradual loss of the remaining caudate neurons. In Nissl-stained sections of the lesion zone where total neuronal density was less than 5% of contralateral control, large neurons were present at all postlesion intervals, forming 38-58% of the remaining neurons. Unexpectedly, a fivefold reduction in the number of large neurons was observed between 2 and 30 weeks postlesion. Also, at 7 and 30 weeks postlesion most of the large neurons were confined to the peripheral region of the lesion. At all postlesion intervals, large neurons retained ultrastructural integrity and some synaptic inputs despite the severe disruption of the surrounding neuropil. Surrounding the lesion zone was a transition zone which exhibited a decrease in total neuronal density to 53-74% of control. In this region the density of large neurons was not diminished, and the proportion of large neurons was elevated in comparison to that of controls at all postlesion intervals. Findings suggest that following excitotoxic lesion of the caudate nucleus there are marked differences between short- and long-term postlesion intervals in the survival and distribution of large neurons. We speculate that an imbalance in the synaptic connections with other caudate neurons leads to the persistent loss of large neurons in the lesion zone at long postlesion intervals. A transition zone surrounding the lesion, where cell loss is less severe than in the lesion zone, exhibits features more characteristic of the neuropathology of HD." @default.
• W2136049998 created "2016-06-24" @default.
• W2136049998 creator A5001439788 @default.
• W2136049998 creator A5029654174 @default.
• W2136049998 date "1989-01-01" @default.
• W2136049998 modified "2023-09-27" @default.
• W2136049998 title "Short- and long-term survival of large neurons in the excitotoxic lesioned rat caudate nucleus: A light and electron microscopic study" @default.
• W2136049998 cites W1934062495 @default.
• W2136049998 cites W1965007932 @default.
• W2136049998 cites W1966001039 @default.
• W2136049998 cites W1969010113 @default.
• W2136049998 cites W1983209655 @default.
• W2136049998 cites W1993470377 @default.
• W2136049998 cites W1996853305 @default.
• W2136049998 cites W2001415828 @default.
• W2136049998 cites W2004159362 @default.
• W2136049998 cites W2006457780 @default.
• W2136049998 cites W2014486882 @default.
• W2136049998 cites W2020882643 @default.
• W2136049998 cites W2022764592 @default.
• W2136049998 cites W2024478624 @default.
• W2136049998 cites W2032008406 @default.
• W2136049998 cites W2032999262 @default.
• W2136049998 cites W2034906758 @default.
• W2136049998 cites W2037256941 @default.
• W2136049998 cites W2039776384 @default.
• W2136049998 cites W2046096408 @default.
• W2136049998 cites W2051353156 @default.
• W2136049998 cites W2062637879 @default.
• W2136049998 cites W2063568787 @default.
• W2136049998 cites W2068592394 @default.
• W2136049998 cites W2068936199 @default.
• W2136049998 cites W2071563998 @default.
• W2136049998 cites W2074887424 @default.
• W2136049998 cites W2075010970 @default.
• W2136049998 cites W2075496897 @default.
• W2136049998 cites W2081814623 @default.
• W2136049998 cites W2083739240 @default.
• W2136049998 cites W2089025505 @default.
• W2136049998 cites W2093103458 @default.
• W2136049998 cites W2106001311 @default.
• W2136049998 doi "https://doi.org/10.1002/syn.890030410" @default.
• W2136049998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2525824" @default.
• W2136049998 hasPublicationYear "1989" @default.
• W2136049998 type Work @default.
• W2136049998 sameAs 2136049998 @default.
• W2136049998 citedByCount "41" @default.
• W2136049998 countsByYear W21360499982017 @default.
• W2136049998 crossrefType "journal-article" @default.
• W2136049998 hasAuthorship W2136049998A5001439788 @default.
• W2136049998 hasAuthorship W2136049998A5029654174 @default.
• W2136049998 hasConcept C105702510 @default.
• W2136049998 hasConcept C134018914 @default.
• W2136049998 hasConcept C142724271 @default.
• W2136049998 hasConcept C169760540 @default.
• W2136049998 hasConcept C190283241 @default.
• W2136049998 hasConcept C2776706248 @default.
• W2136049998 hasConcept C2776993930 @default.
• W2136049998 hasConcept C2777831001 @default.
• W2136049998 hasConcept C2777896816 @default.
• W2136049998 hasConcept C2781012912 @default.
• W2136049998 hasConcept C2781156865 @default.
• W2136049998 hasConcept C2781423529 @default.
• W2136049998 hasConcept C31573885 @default.
• W2136049998 hasConcept C515207424 @default.
• W2136049998 hasConcept C529278444 @default.
• W2136049998 hasConcept C55493867 @default.
• W2136049998 hasConcept C71924100 @default.
• W2136049998 hasConcept C86803240 @default.
• W2136049998 hasConceptScore W2136049998C105702510 @default.
• W2136049998 hasConceptScore W2136049998C134018914 @default.
• W2136049998 hasConceptScore W2136049998C142724271 @default.
• W2136049998 hasConceptScore W2136049998C169760540 @default.
• W2136049998 hasConceptScore W2136049998C190283241 @default.
• W2136049998 hasConceptScore W2136049998C2776706248 @default.
• W2136049998 hasConceptScore W2136049998C2776993930 @default.
• W2136049998 hasConceptScore W2136049998C2777831001 @default.
• W2136049998 hasConceptScore W2136049998C2777896816 @default.
• W2136049998 hasConceptScore W2136049998C2781012912 @default.
• W2136049998 hasConceptScore W2136049998C2781156865 @default.
• W2136049998 hasConceptScore W2136049998C2781423529 @default.
• W2136049998 hasConceptScore W2136049998C31573885 @default.
• W2136049998 hasConceptScore W2136049998C515207424 @default.
• W2136049998 hasConceptScore W2136049998C529278444 @default.
• W2136049998 hasConceptScore W2136049998C55493867 @default.
• W2136049998 hasConceptScore W2136049998C71924100 @default.
• W2136049998 hasConceptScore W2136049998C86803240 @default.
• W2136049998 hasIssue "4" @default.
• W2136049998 hasLocation W21360499981 @default.
• W2136049998 hasLocation W21360499982 @default.
• W2136049998 hasOpenAccess W2136049998 @default.
• W2136049998 hasPrimaryLocation W21360499981 @default.
• W2136049998 hasRelatedWork W2001948961 @default.
• W2136049998 hasRelatedWork W2012906643 @default.
• W2136049998 hasRelatedWork W2029803348 @default.
• W2136049998 hasRelatedWork W2068230856 @default.
• W2136049998 hasRelatedWork W2102254677 @default.
• W2136049998 hasRelatedWork W2136049998 @default.

• next