FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136083359> ?p ?o ?g. }

• W2136083359 endingPage "83" @default.
• W2136083359 startingPage "77" @default.
• W2136083359 abstract "Medial nucleus tractus solitarius (mNTS) neurons express leptin receptors (LepRs), and intra-mNTS delivery of leptin reduces food intake and body weight. Here, the contribution of endogenous LepR signaling in mNTS neurons to energy balance control was examined. Knockdown of LepR in mNTS and area postrema (AP) neurons of rats (LepRKD) via adeno-associated virus short hairpin RNA-interference (AAV-shRNAi) resulted in significant hyperphagia for chow, high-fat, and sucrose diets, yielding increased body weight and adiposity. The chronic hyperphagia of mNTS/AP LepRKD rats is likely mediated by a reduction in leptin potentiation of gastrointestinal satiation signaling, as LepRKD rats showed decreased sensitivity to the intake-reducing effects of cholecystokinin. LepRKD rats showed increased basal AMP-kinase activity in mNTS/AP micropunches, and pharmacological data suggest that this increase provides a likely mechanism for their chronic hyperphagia. Overall these findings demonstrate that LepRs in mNTS and AP neurons are required for normal energy balance control." @default.
• W2136083359 created "2016-06-24" @default.
• W2136083359 creator A5011685656 @default.
• W2136083359 creator A5016431924 @default.
• W2136083359 creator A5065258001 @default.
• W2136083359 creator A5067849248 @default.
• W2136083359 creator A5067962088 @default.
• W2136083359 creator A5072040580 @default.
• W2136083359 creator A5085016374 @default.
• W2136083359 date "2010-01-01" @default.
• W2136083359 modified "2023-09-30" @default.
• W2136083359 title "Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation" @default.
• W2136083359 cites W1516631422 @default.
• W2136083359 cites W1964904380 @default.
• W2136083359 cites W1977915489 @default.
• W2136083359 cites W1990876441 @default.
• W2136083359 cites W1996713062 @default.
• W2136083359 cites W1999938411 @default.
• W2136083359 cites W2003456064 @default.
• W2136083359 cites W2003967044 @default.
• W2136083359 cites W2013299787 @default.
• W2136083359 cites W2020670112 @default.
• W2136083359 cites W2024023663 @default.
• W2136083359 cites W2035703541 @default.
• W2136083359 cites W2050684182 @default.
• W2136083359 cites W2054966058 @default.
• W2136083359 cites W2060914572 @default.
• W2136083359 cites W2071643732 @default.
• W2136083359 cites W2073893647 @default.
• W2136083359 cites W2074303577 @default.
• W2136083359 cites W2091576257 @default.
• W2136083359 cites W2091988898 @default.
• W2136083359 cites W2092530840 @default.
• W2136083359 cites W2099518333 @default.
• W2136083359 cites W2102238490 @default.
• W2136083359 cites W2109684842 @default.
• W2136083359 cites W2111100731 @default.
• W2136083359 cites W2114711378 @default.
• W2136083359 cites W2134520365 @default.
• W2136083359 cites W4242805754 @default.
• W2136083359 cites W4254970928 @default.
• W2136083359 doi "https://doi.org/10.1016/j.cmet.2009.10.009" @default.
• W2136083359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2807619" @default.
• W2136083359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27076082" @default.
• W2136083359 hasPublicationYear "2010" @default.
• W2136083359 type Work @default.
• W2136083359 sameAs 2136083359 @default.
• W2136083359 citedByCount "209" @default.
• W2136083359 countsByYear W21360833592012 @default.
• W2136083359 countsByYear W21360833592013 @default.
• W2136083359 countsByYear W21360833592014 @default.
• W2136083359 countsByYear W21360833592015 @default.
• W2136083359 countsByYear W21360833592016 @default.
• W2136083359 countsByYear W21360833592017 @default.
• W2136083359 countsByYear W21360833592018 @default.
• W2136083359 countsByYear W21360833592019 @default.
• W2136083359 countsByYear W21360833592020 @default.
• W2136083359 countsByYear W21360833592021 @default.
• W2136083359 countsByYear W21360833592022 @default.
• W2136083359 countsByYear W21360833592023 @default.
• W2136083359 crossrefType "journal-article" @default.
• W2136083359 hasAuthorship W2136083359A5011685656 @default.
• W2136083359 hasAuthorship W2136083359A5016431924 @default.
• W2136083359 hasAuthorship W2136083359A5065258001 @default.
• W2136083359 hasAuthorship W2136083359A5067849248 @default.
• W2136083359 hasAuthorship W2136083359A5067962088 @default.
• W2136083359 hasAuthorship W2136083359A5072040580 @default.
• W2136083359 hasAuthorship W2136083359A5085016374 @default.
• W2136083359 hasBestOaLocation W21360833591 @default.
• W2136083359 hasConcept C126322002 @default.
• W2136083359 hasConcept C134018914 @default.
• W2136083359 hasConcept C14372207 @default.
• W2136083359 hasConcept C170493617 @default.
• W2136083359 hasConcept C185592680 @default.
• W2136083359 hasConcept C24998067 @default.
• W2136083359 hasConcept C2776459250 @default.
• W2136083359 hasConcept C2777593968 @default.
• W2136083359 hasConcept C2779929655 @default.
• W2136083359 hasConcept C2780613262 @default.
• W2136083359 hasConcept C2781404750 @default.
• W2136083359 hasConcept C511355011 @default.
• W2136083359 hasConcept C529278444 @default.
• W2136083359 hasConcept C71924100 @default.
• W2136083359 hasConcept C86803240 @default.
• W2136083359 hasConceptScore W2136083359C126322002 @default.
• W2136083359 hasConceptScore W2136083359C134018914 @default.
• W2136083359 hasConceptScore W2136083359C14372207 @default.
• W2136083359 hasConceptScore W2136083359C170493617 @default.
• W2136083359 hasConceptScore W2136083359C185592680 @default.
• W2136083359 hasConceptScore W2136083359C24998067 @default.
• W2136083359 hasConceptScore W2136083359C2776459250 @default.
• W2136083359 hasConceptScore W2136083359C2777593968 @default.
• W2136083359 hasConceptScore W2136083359C2779929655 @default.
• W2136083359 hasConceptScore W2136083359C2780613262 @default.
• W2136083359 hasConceptScore W2136083359C2781404750 @default.
• W2136083359 hasConceptScore W2136083359C511355011 @default.
• W2136083359 hasConceptScore W2136083359C529278444 @default.
• W2136083359 hasConceptScore W2136083359C71924100 @default.

• next