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- W2136099797 abstract "Inappropriate signaling of the RET receptor tyrosine kinase causes different forms of human thyroid malignancy. We have previously identified the adaptor Grap-2 as RET binding protein. To verify involvement of Grap-2 in RET oncogenic signaling we performed sequence and expression analysis of Grap-2 in 15 human MTC samples. All tumors displayed marked Grap-2 mRNA and protein expression without a linear correlation. Beyond one conservative base pair substitution we detected no further alteration in genomic Grap-2 sequence. Consistent Grap-2 expression suggests a specific role for this adaptor in human MTC, while qualitative alterations do not appear to influence RET signaling." @default.
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- W2136099797 date "2009-03-01" @default.
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- W2136099797 title "Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma" @default.
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- W2136099797 doi "https://doi.org/10.1016/j.canlet.2008.10.010" @default.
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