Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136152051> ?p ?o ?g. }
- W2136152051 endingPage "e2012001" @default.
- W2136152051 startingPage "e2012001" @default.
- W2136152051 abstract "Xmn-1 polymorphism is a known factor, which increases fetal haemoglobin production. Among the inherited disorders of blood, thalassaemia and SCD constitutes a major bulk of genetic diseases in India. Our aim was to verify the role of the Xmn I polymorphism as a modulating factor in sickle cell patients and frequency of the polymorphism in Indian sickle cell patients. Subjects were 60 sickles homozygous and 75 sickle beta thalassemia patients. 5 ml blood samples collected from patients. Screening of sickle patients done by HPLC. An automated cell analyzer SYSMEX (K-4500 Model) used to analyze the CBC of patients.Xmn1 polymorphism analysis done by PCR-RFLP and Statistical analysis was performed on GraphPad static’s software. t test applied to compare the means amongst group. Among the sickle homozygous 27 were heterozygous (+/-) and 19 were homozygous (+/+) while 30 were heterozygous and 24 were homozygous in sickle β-thalassemia patients. Extremely significant differences (p-value <0.001) of hematological parameters seen among patient with xmn-1 carrier and without the xmn-1 carrier. In our cases the clinical symptom less frequent and higher HbF level with Xmn-1 carriers. Presence of Xmn-1 polymorphism in sickle patients with higher HbF that improve phenotypic presentation in the sickle cell patients. We conclude that the phenotype of Indian sickle cell patients influenced by Xmn-1 polymorphism." @default.
- W2136152051 created "2016-06-24" @default.
- W2136152051 creator A5015426373 @default.
- W2136152051 creator A5055583649 @default.
- W2136152051 creator A5061900237 @default.
- W2136152051 creator A5087294492 @default.
- W2136152051 date "2012-01-15" @default.
- W2136152051 modified "2023-10-17" @default.
- W2136152051 title "MODULATING EFFECT OF THE −158 GΓ (C→T) XMN-1 POLYMORPHISM IN INDIAN SICKLE CELL PATIENTS" @default.
- W2136152051 cites W1967571715 @default.
- W2136152051 cites W1970819420 @default.
- W2136152051 cites W1972491801 @default.
- W2136152051 cites W1990599619 @default.
- W2136152051 cites W2006641199 @default.
- W2136152051 cites W2006754069 @default.
- W2136152051 cites W2008087687 @default.
- W2136152051 cites W2019325725 @default.
- W2136152051 cites W2024571301 @default.
- W2136152051 cites W2070849858 @default.
- W2136152051 cites W2080209759 @default.
- W2136152051 cites W2121678970 @default.
- W2136152051 cites W2153076975 @default.
- W2136152051 cites W2163032065 @default.
- W2136152051 cites W297744419 @default.
- W2136152051 cites W2272954997 @default.
- W2136152051 cites W3144957394 @default.
- W2136152051 doi "https://doi.org/10.4084/mjhid.2012.001" @default.
- W2136152051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3279316" @default.
- W2136152051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22348183" @default.
- W2136152051 hasPublicationYear "2012" @default.
- W2136152051 type Work @default.
- W2136152051 sameAs 2136152051 @default.
- W2136152051 citedByCount "14" @default.
- W2136152051 countsByYear W21361520512014 @default.
- W2136152051 countsByYear W21361520512015 @default.
- W2136152051 countsByYear W21361520512016 @default.
- W2136152051 countsByYear W21361520512017 @default.
- W2136152051 countsByYear W21361520512018 @default.
- W2136152051 countsByYear W21361520512019 @default.
- W2136152051 countsByYear W21361520512021 @default.
- W2136152051 countsByYear W21361520512022 @default.
- W2136152051 crossrefType "journal-article" @default.
- W2136152051 hasAuthorship W2136152051A5015426373 @default.
- W2136152051 hasAuthorship W2136152051A5055583649 @default.
- W2136152051 hasAuthorship W2136152051A5061900237 @default.
- W2136152051 hasAuthorship W2136152051A5087294492 @default.
- W2136152051 hasBestOaLocation W21361520511 @default.
- W2136152051 hasConcept C104317684 @default.
- W2136152051 hasConcept C126322002 @default.
- W2136152051 hasConcept C135763542 @default.
- W2136152051 hasConcept C142724271 @default.
- W2136152051 hasConcept C149737253 @default.
- W2136152051 hasConcept C172680121 @default.
- W2136152051 hasConcept C2776317666 @default.
- W2136152051 hasConcept C2777799968 @default.
- W2136152051 hasConcept C2778620579 @default.
- W2136152051 hasConcept C2779134260 @default.
- W2136152051 hasConcept C2779234561 @default.
- W2136152051 hasConcept C2780976302 @default.
- W2136152051 hasConcept C54355233 @default.
- W2136152051 hasConcept C71924100 @default.
- W2136152051 hasConcept C86803240 @default.
- W2136152051 hasConcept C90924648 @default.
- W2136152051 hasConceptScore W2136152051C104317684 @default.
- W2136152051 hasConceptScore W2136152051C126322002 @default.
- W2136152051 hasConceptScore W2136152051C135763542 @default.
- W2136152051 hasConceptScore W2136152051C142724271 @default.
- W2136152051 hasConceptScore W2136152051C149737253 @default.
- W2136152051 hasConceptScore W2136152051C172680121 @default.
- W2136152051 hasConceptScore W2136152051C2776317666 @default.
- W2136152051 hasConceptScore W2136152051C2777799968 @default.
- W2136152051 hasConceptScore W2136152051C2778620579 @default.
- W2136152051 hasConceptScore W2136152051C2779134260 @default.
- W2136152051 hasConceptScore W2136152051C2779234561 @default.
- W2136152051 hasConceptScore W2136152051C2780976302 @default.
- W2136152051 hasConceptScore W2136152051C54355233 @default.
- W2136152051 hasConceptScore W2136152051C71924100 @default.
- W2136152051 hasConceptScore W2136152051C86803240 @default.
- W2136152051 hasConceptScore W2136152051C90924648 @default.
- W2136152051 hasIssue "1" @default.
- W2136152051 hasLocation W21361520511 @default.
- W2136152051 hasLocation W21361520512 @default.
- W2136152051 hasLocation W21361520513 @default.
- W2136152051 hasLocation W21361520514 @default.
- W2136152051 hasLocation W21361520515 @default.
- W2136152051 hasLocation W21361520516 @default.
- W2136152051 hasOpenAccess W2136152051 @default.
- W2136152051 hasPrimaryLocation W21361520511 @default.
- W2136152051 hasRelatedWork W1965738657 @default.
- W2136152051 hasRelatedWork W2037204994 @default.
- W2136152051 hasRelatedWork W2088111470 @default.
- W2136152051 hasRelatedWork W2136152051 @default.
- W2136152051 hasRelatedWork W2322254905 @default.
- W2136152051 hasRelatedWork W2409009119 @default.
- W2136152051 hasRelatedWork W242090125 @default.
- W2136152051 hasRelatedWork W2560711617 @default.
- W2136152051 hasRelatedWork W2791021987 @default.
- W2136152051 hasRelatedWork W4241864284 @default.