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- W2136157696 abstract "We present a case in which a patient took an overdose of captopril (Capoten) and alprazolam (Xanax) in a suicide attempt. The patient presented with hypotension (systolic blood pressure of 80 mm Hg) and drowsiness. The hypotension initially responded to administration of intravenous fluids and dopamine; however, it recurred twice at 18.5 and 24.5 hours after ingestion. These episodes again responded to administration of fluids and dopamine. A plasma captopril level of 27 391.1 nmol/L (5982 ng/mL) was documented, as well as a depressed level of angiotensin converting enzyme. Captopril is an angiotensin converting enzyme inhibitor used in the management of hypertension and ventricular failure; to our knowledge, this is the first case of an acute captopril overdose reported in the English-language literature. The role of captopril in inducing hypotension is discussed herein. (<i>JAMA</i>1988;259:3302-3305)" @default.
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- W2136157696 date "1988-06-10" @default.
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- W2136157696 title "Captopril Overdose Resulting in Hypotension" @default.
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- W2136157696 doi "https://doi.org/10.1001/jama.1988.03720220048025" @default.
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