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- W2136171593 startingPage "331" @default.
- W2136171593 abstract "Biosynthesis of proteins – from translation to folding to export – encompasses a complex set of events that are exquisitely regulated and scrutinized to ensure the functional quality of the end products. Cells have evolved to capitalize on multiple post-translational modifications in addition to primary structure to indicate the folding status of nascent polypeptides to the chaperones and other proteins that assist in their folding and export. These modifications can also, in the case of irreversibly misfolded candidates, signal the need for dislocation and degradation. The current Review focuses on the glycoprotein quality-control (GQC) system that utilizes protein N-glycosylation and N-glycan trimming to direct nascent glycopolypeptides through the folding, export and dislocation pathways in the endoplasmic reticulum (ER). A diverse set of pathological conditions rooted in defective as well as over-vigilant ER quality-control systems have been identified, underlining its importance in human health and disease. We describe the GQC pathways and highlight disease and animal models that have been instrumental in clarifying our current understanding of these processes." @default.
- W2136171593 created "2016-06-24" @default.
- W2136171593 creator A5013915309 @default.
- W2136171593 creator A5015378855 @default.
- W2136171593 creator A5029311054 @default.
- W2136171593 date "2014-03-01" @default.
- W2136171593 modified "2023-10-02" @default.
- W2136171593 title "Glycoprotein folding and quality-control mechanisms in protein-folding diseases" @default.
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