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- W2136171792 abstract "Continued spread of HIV infection among women has led to the use of antiretrovirals in pregnant women and their newborns. Regional strategies to prevent mother-to-child transmission are evolving. Altered drug disposition during pregnancy may require altered dosing or 'boosted' therapies to avoid treatment failure. Maturing drug elimination pathways in newborns must also be considered for effective therapy. Potential teratogenic effects and increased sensitivity to antiretroviral toxicities might be encountered in this population. Use of highly active antiretroviral therapy (HAART) to suppress viral replication combined with formula feeding can reduce the rate of mother-to-child HIV transmission to less than 2%. In resource-limited settings, less intensive regimens including zidovudine, lamivudine and nevirapine still substantially reduce mother-to-child transmission. Although difficult to perform, clinical trials to determine the safety, pharmacokinetics and optimal dosing of antiretroviral in pregnant women and their newborns are urgently needed." @default.
- W2136171792 created "2016-06-24" @default.
- W2136171792 creator A5025772367 @default.
- W2136171792 creator A5040076878 @default.
- W2136171792 creator A5085465326 @default.
- W2136171792 date "2005-04-01" @default.
- W2136171792 modified "2023-10-18" @default.
- W2136171792 title "Pharmacotherapy of perinatal HIV" @default.
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- W2136171792 doi "https://doi.org/10.1016/j.siny.2004.10.001" @default.
- W2136171792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15701581" @default.
- W2136171792 hasPublicationYear "2005" @default.
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