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• W2136178051 startingPage "1113" @default.
• W2136178051 abstract "Neurotransmitter is released from nerve terminals by Ca2+-dependent exocytosis through many steps. SNARE proteins are key components at the priming and fusion steps, and the priming step is modulated by cAMP-dependent protein kinase (PKA), which causes synaptic plasticity. We show that the SNARE regulatory protein tomosyn is directly phosphorylated by PKA, which reduces its interaction with syntaxin-1 (a component of SNAREs) and enhances the formation of the SNARE complex. Electrophysiological studies using cultured superior cervical ganglion (SCG) neurons revealed that this enhanced formation of the SNARE complex by the PKA-catalyzed phosphorylation of tomosyn increased the fusion-competent readily releasable pool of synaptic vesicles and, thereby, enhanced neurotransmitter release. This mechanism was indeed involved in the facilitation of neurotransmitter release that was induced by a potent biological mediator, the pituitary adenylate cyclase-activating polypeptide, in SCG neurons. We describe the roles and modes of action of PKA and tomosyn in Ca2+-dependent neurotransmitter release." @default.
• W2136178051 created "2016-06-24" @default.
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• W2136178051 date "2005-09-26" @default.
• W2136178051 modified "2023-10-15" @default.
• W2136178051 title "PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter" @default.
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• W2136178051 cites W1601289488 @default.
• W2136178051 cites W1700565657 @default.
• W2136178051 cites W1822252127 @default.
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• W2136178051 cites W1998983314 @default.
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• W2136178051 doi "https://doi.org/10.1083/jcb.200504055" @default.
• W2136178051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2171531" @default.
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