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• W2136180536 endingPage "1999" @default.
• W2136180536 startingPage "1990" @default.
• W2136180536 abstract "The Mos protein kinase is a key regulator of vertebrate oocyte maturation. Oocyte-specific Mos protein expression is subject to translational control. In the frog Xenopus, the translation of Mos protein requires the progesterone-induced polyadenylation of the maternal Mos mRNA, which is present in the oocyte cytoplasm. Both theXenopus p42 mitogen-activated protein kinase (MAPK) and maturation-promoting factor (MPF) signaling pathways have been proposed to mediate progesterone-stimulated oocyte maturation. In this study, we have determined the relative contributions of the MAPK and MPF signaling pathways to Mos mRNA polyadenylation. We report that progesterone-induced Mos mRNA polyadenylation was attenuated in oocytes expressing the MAPK phosphatase rVH6. Moreover, inhibition of MAPK signaling blocked progesterone-induced Mos protein accumulation. Activation of the MAPK pathway by injection of RNA encoding Mos was sufficient to induce both the polyadenylation of synthetic Mos mRNA substrates and the accumulation of endogenous Mos protein in the absence of MPF signaling. Activation of MPF, by injection of cyclin B1 RNA or purified cyclin B1 protein, also induced both Mos protein accumulation and Mos mRNA polyadenylation. However, this action of MPF required MAPK activity. By contrast, the cytoplasmic polyadenylation of maternal cyclin B1 mRNA was stimulated by MPF in a MAPK-independent manner, thus revealing a differential regulation of maternal mRNA polyadenylation by the MAPK and MPF signaling pathways. We propose that MAPK-stimulated Mos mRNA cytoplasmic polyadenylation is a key component of the positive-feedback loop, which contributes to the all-or-none process of oocyte maturation." @default.
• W2136180536 created "2016-06-24" @default.
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• W2136180536 creator A5063253877 @default.
• W2136180536 creator A5074008409 @default.
• W2136180536 creator A5084812887 @default.
• W2136180536 date "1999-03-01" @default.
• W2136180536 modified "2023-10-11" @default.
• W2136180536 title "The Mitogen-Activated Protein Kinase Signaling Pathway Stimulates Mos mRNA Cytoplasmic Polyadenylation during <i>Xenopus</i> Oocyte Maturation" @default.
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• W2136180536 doi "https://doi.org/10.1128/mcb.19.3.1990" @default.
• W2136180536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/83992" @default.
• W2136180536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10022886" @default.
• W2136180536 hasPublicationYear "1999" @default.
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