Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136204273> ?p ?o ?g. }
- W2136204273 endingPage "598" @default.
- W2136204273 startingPage "589" @default.
- W2136204273 abstract "Cyclic AMP-dependent transcription factor-3 (ATF3), a stress sensor, plays an essential role in cells to maintain homeostasis and has diverse functions in cellular survival and death signal pathways. ATF3 is a novel regulator of p53 protein stability and function. The activities of ATF3 are modulated by post-translational modifications (PTMs), such as ubiquitination, but whether it is modified by small ubiquitin-related modifier (SUMO) remains unknown. The aim of this study was to investigate whether ATF3 is post-translationally modified by SUMO proteins and also to elucidate SUMOylation of ATF3 on TP53 gene activity. Here we report that ATF3 is clearly defined as a SUMO target protein both in vitro SUMOylation assay using recombinant proteins and at the cellular levels. Furthermore, ATF3 interacted with UBE2I, the only SUMO E2 enzyme found so far. In addition, PIAS3β (a SUMO E3 ligase) enhanced and SENP2 and SENP7 (two SUMOylation proteases) decreased SUMOylation of ATF3, respectively. Finally, we found that ATF3 is selectively SUMOylated at lysine residue 42 but the SUMOylation does not alter subcellular localization of ATF3. We then characterized the functional role of ATF3 SUMOylation on TP53 gene expression. We found that SUMOylation of ATF3 is required for full repression of TP53 gene. Overall, we provide the first evidence that ATF3 is post-translationally modified by SUMO and SUMOylation of ATF3 plays a functional role in regulation of TP53 gene activity." @default.
- W2136204273 created "2016-06-24" @default.
- W2136204273 creator A5023883029 @default.
- W2136204273 creator A5034853997 @default.
- W2136204273 creator A5040646593 @default.
- W2136204273 creator A5069564276 @default.
- W2136204273 creator A5088458011 @default.
- W2136204273 creator A5089734822 @default.
- W2136204273 date "2013-01-22" @default.
- W2136204273 modified "2023-10-10" @default.
- W2136204273 title "SUMOylation of ATF3 alters its transcriptional activity on regulation of<i>TP53</i>gene" @default.
- W2136204273 cites W1517778647 @default.
- W2136204273 cites W1541379084 @default.
- W2136204273 cites W1965226335 @default.
- W2136204273 cites W1966584824 @default.
- W2136204273 cites W1970488978 @default.
- W2136204273 cites W1972166544 @default.
- W2136204273 cites W1979275431 @default.
- W2136204273 cites W1993180829 @default.
- W2136204273 cites W1994473965 @default.
- W2136204273 cites W2004722555 @default.
- W2136204273 cites W2006976630 @default.
- W2136204273 cites W2019058511 @default.
- W2136204273 cites W2021509563 @default.
- W2136204273 cites W2032278957 @default.
- W2136204273 cites W2032811319 @default.
- W2136204273 cites W2040888486 @default.
- W2136204273 cites W2041968244 @default.
- W2136204273 cites W2044499746 @default.
- W2136204273 cites W2047885999 @default.
- W2136204273 cites W2047978738 @default.
- W2136204273 cites W2051388125 @default.
- W2136204273 cites W2053338034 @default.
- W2136204273 cites W2054147049 @default.
- W2136204273 cites W2059007379 @default.
- W2136204273 cites W2075025942 @default.
- W2136204273 cites W2080047282 @default.
- W2136204273 cites W2081302775 @default.
- W2136204273 cites W2081766744 @default.
- W2136204273 cites W2087535194 @default.
- W2136204273 cites W2096764229 @default.
- W2136204273 cites W2100983536 @default.
- W2136204273 cites W2105296700 @default.
- W2136204273 cites W2111369228 @default.
- W2136204273 cites W2112188875 @default.
- W2136204273 cites W2112441454 @default.
- W2136204273 cites W2116755431 @default.
- W2136204273 cites W2118810511 @default.
- W2136204273 cites W2122044343 @default.
- W2136204273 cites W2122537353 @default.
- W2136204273 cites W2131705781 @default.
- W2136204273 cites W2138090110 @default.
- W2136204273 cites W2141829793 @default.
- W2136204273 cites W2145690501 @default.
- W2136204273 cites W2152573239 @default.
- W2136204273 cites W2158748750 @default.
- W2136204273 cites W2162093159 @default.
- W2136204273 cites W2169995647 @default.
- W2136204273 cites W4246077736 @default.
- W2136204273 doi "https://doi.org/10.1002/jcb.24396" @default.
- W2136204273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22991139" @default.
- W2136204273 hasPublicationYear "2013" @default.
- W2136204273 type Work @default.
- W2136204273 sameAs 2136204273 @default.
- W2136204273 citedByCount "18" @default.
- W2136204273 countsByYear W21362042732013 @default.
- W2136204273 countsByYear W21362042732014 @default.
- W2136204273 countsByYear W21362042732015 @default.
- W2136204273 countsByYear W21362042732016 @default.
- W2136204273 countsByYear W21362042732017 @default.
- W2136204273 countsByYear W21362042732018 @default.
- W2136204273 countsByYear W21362042732019 @default.
- W2136204273 countsByYear W21362042732021 @default.
- W2136204273 countsByYear W21362042732022 @default.
- W2136204273 crossrefType "journal-article" @default.
- W2136204273 hasAuthorship W2136204273A5023883029 @default.
- W2136204273 hasAuthorship W2136204273A5034853997 @default.
- W2136204273 hasAuthorship W2136204273A5040646593 @default.
- W2136204273 hasAuthorship W2136204273A5069564276 @default.
- W2136204273 hasAuthorship W2136204273A5088458011 @default.
- W2136204273 hasAuthorship W2136204273A5089734822 @default.
- W2136204273 hasConcept C101762097 @default.
- W2136204273 hasConcept C104317684 @default.
- W2136204273 hasConcept C134459356 @default.
- W2136204273 hasConcept C150194340 @default.
- W2136204273 hasConcept C153911025 @default.
- W2136204273 hasConcept C157880135 @default.
- W2136204273 hasConcept C171350616 @default.
- W2136204273 hasConcept C185592680 @default.
- W2136204273 hasConcept C25602115 @default.
- W2136204273 hasConcept C2776016237 @default.
- W2136204273 hasConcept C515207424 @default.
- W2136204273 hasConcept C54355233 @default.
- W2136204273 hasConcept C86803240 @default.
- W2136204273 hasConcept C95444343 @default.
- W2136204273 hasConceptScore W2136204273C101762097 @default.
- W2136204273 hasConceptScore W2136204273C104317684 @default.
- W2136204273 hasConceptScore W2136204273C134459356 @default.