Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136209291> ?p ?o ?g. }
- W2136209291 endingPage "2559" @default.
- W2136209291 startingPage "2551" @default.
- W2136209291 abstract "Abstract Cerebral malaria (CM) is the most severe complication of malaria. The murine Plasmodium berghei ANKA (PbA) infection model has helped to identify crucial players in the pathogenesis of CM. However, the role of pattern recognition receptors in innate immunity to CM induction is still poorly understood. C-type lectin receptors (CLRs) represent a family of pattern recognition receptors that recognize carbohydrate structures on pathogens and self-Ags often in a Ca2+-dependent manner. In this study, we investigated the role of the CLR dendritic cell immunoreceptor (DCIR) in the genesis of CM. Using the murine PbA infection, we show in this article that DCIR is essential for the development of CM. Although PbA infection led to 80% CM in wild-type C57BL/6 mice, DCIR-deficient mice were highly protected with only 15% CM development. In accordance with the reduced CM incidence in DCIR−/− mice, CD8+ T cell sequestration was markedly reduced in brains of PbA-infected DCIR−/− mice, which was accompanied by reduced brain inflammation. Reduced T cell sequestration in the brain was caused by decreased TNF-α levels in sera, as well as a modulated activation of CD4+ and CD8+ T cells in spleen of PbA-infected DCIR−/− mice. This study indicates that DCIR is critically involved in CM induction, thus highlighting the importance of this CLR in innate immunity during malaria infection." @default.
- W2136209291 created "2016-06-24" @default.
- W2136209291 creator A5008512379 @default.
- W2136209291 creator A5011041473 @default.
- W2136209291 creator A5035008126 @default.
- W2136209291 creator A5047633666 @default.
- W2136209291 date "2013-09-01" @default.
- W2136209291 modified "2023-10-11" @default.
- W2136209291 title "The C-Type Lectin Receptor DCIR Is Crucial for the Development of Experimental Cerebral Malaria" @default.
- W2136209291 cites W1492482164 @default.
- W2136209291 cites W1497860205 @default.
- W2136209291 cites W1586942665 @default.
- W2136209291 cites W1607744302 @default.
- W2136209291 cites W1610233406 @default.
- W2136209291 cites W1614456110 @default.
- W2136209291 cites W1661544713 @default.
- W2136209291 cites W1953963427 @default.
- W2136209291 cites W1966439617 @default.
- W2136209291 cites W1990290004 @default.
- W2136209291 cites W1991773233 @default.
- W2136209291 cites W1993067459 @default.
- W2136209291 cites W2001219616 @default.
- W2136209291 cites W2005234042 @default.
- W2136209291 cites W2006501593 @default.
- W2136209291 cites W2008186052 @default.
- W2136209291 cites W2014904052 @default.
- W2136209291 cites W2022636507 @default.
- W2136209291 cites W2022911752 @default.
- W2136209291 cites W2025928231 @default.
- W2136209291 cites W2038859753 @default.
- W2136209291 cites W2039227742 @default.
- W2136209291 cites W2048992607 @default.
- W2136209291 cites W2060000199 @default.
- W2136209291 cites W2064938586 @default.
- W2136209291 cites W2073541049 @default.
- W2136209291 cites W2079744876 @default.
- W2136209291 cites W2084697718 @default.
- W2136209291 cites W2085077927 @default.
- W2136209291 cites W2087166273 @default.
- W2136209291 cites W2091019029 @default.
- W2136209291 cites W2097504721 @default.
- W2136209291 cites W2099907868 @default.
- W2136209291 cites W2100359781 @default.
- W2136209291 cites W2100704940 @default.
- W2136209291 cites W2102564122 @default.
- W2136209291 cites W2103615574 @default.
- W2136209291 cites W2107398045 @default.
- W2136209291 cites W2114216755 @default.
- W2136209291 cites W2114900483 @default.
- W2136209291 cites W2119428502 @default.
- W2136209291 cites W2121287211 @default.
- W2136209291 cites W2127273721 @default.
- W2136209291 cites W2133972984 @default.
- W2136209291 cites W2137670912 @default.
- W2136209291 cites W2139366119 @default.
- W2136209291 cites W2140235930 @default.
- W2136209291 cites W2142649160 @default.
- W2136209291 cites W2142945482 @default.
- W2136209291 cites W2146353248 @default.
- W2136209291 cites W2147820406 @default.
- W2136209291 cites W2148576770 @default.
- W2136209291 cites W2154758884 @default.
- W2136209291 cites W2156686268 @default.
- W2136209291 cites W2256588368 @default.
- W2136209291 cites W80579013 @default.
- W2136209291 doi "https://doi.org/10.4049/jimmunol.1203451" @default.
- W2136209291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23918990" @default.
- W2136209291 hasPublicationYear "2013" @default.
- W2136209291 type Work @default.
- W2136209291 sameAs 2136209291 @default.
- W2136209291 citedByCount "36" @default.
- W2136209291 countsByYear W21362092912014 @default.
- W2136209291 countsByYear W21362092912015 @default.
- W2136209291 countsByYear W21362092912016 @default.
- W2136209291 countsByYear W21362092912017 @default.
- W2136209291 countsByYear W21362092912018 @default.
- W2136209291 countsByYear W21362092912019 @default.
- W2136209291 countsByYear W21362092912020 @default.
- W2136209291 countsByYear W21362092912021 @default.
- W2136209291 countsByYear W21362092912022 @default.
- W2136209291 countsByYear W21362092912023 @default.
- W2136209291 crossrefType "journal-article" @default.
- W2136209291 hasAuthorship W2136209291A5008512379 @default.
- W2136209291 hasAuthorship W2136209291A5011041473 @default.
- W2136209291 hasAuthorship W2136209291A5035008126 @default.
- W2136209291 hasAuthorship W2136209291A5047633666 @default.
- W2136209291 hasBestOaLocation W21362092911 @default.
- W2136209291 hasConcept C106257327 @default.
- W2136209291 hasConcept C136449434 @default.
- W2136209291 hasConcept C167672396 @default.
- W2136209291 hasConcept C170493617 @default.
- W2136209291 hasConcept C203014093 @default.
- W2136209291 hasConcept C2777237215 @default.
- W2136209291 hasConcept C2778048844 @default.
- W2136209291 hasConcept C2778371730 @default.
- W2136209291 hasConcept C2779341262 @default.
- W2136209291 hasConcept C2780931953 @default.
- W2136209291 hasConcept C2780942790 @default.