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• W2136222303 endingPage "3032" @default.
• W2136222303 startingPage "3028" @default.
• W2136222303 abstract "ABSTRACT We tested the impact of individual PBP 5 mutations on expression of ampicillin resistance in Enterococcus faecium using a shuttle plasmid designed to facilitate expression of cloned pbp5 in ampicillin-susceptible E. faecium D344SRF. Substitutions that had been implicated in contributing to the resistance of clinical strains conferred only modest levels of resistance when they were present as single point mutations. The levels of resistance were amplified when some mutations were present in combination. In particular, a methionine-to-alanine change at position 485 (in close proximity to the active site) combined with the insertion of a serine at position 466 (located in a loop that forms the outer edge of the active site) was associated with the highest levels of resistance to all β-lactams. Affinity for penicillin generally correlated with β-lactam MICs for the mutants, but these associations were not strictly proportional." @default.
• W2136222303 created "2016-06-24" @default.
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• W2136222303 date "2004-08-01" @default.
• W2136222303 modified "2023-10-18" @default.
• W2136222303 title "Impact of Specific <i>pbp5</i> Mutations on Expression of β-Lactam Resistance in <i>Enterococcus faecium</i>" @default.
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• W2136222303 doi "https://doi.org/10.1128/aac.48.8.3028-3032.2004" @default.
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