FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136245027> ?p ?o ?g. }

• W2136245027 endingPage "9236" @default.
• W2136245027 startingPage "9231" @default.
• W2136245027 abstract "Comparison of crystallized MHC class II*peptide complexes has revealed that, in addition to pocket interactions involving the peptide side chains, peptide binding to MHC class II molecules is characterized by a series of hydrogen bonds between genetically conserved amino acid residues in the class II molecule and the main chain of the peptide. Many class II*peptide structures have two sets of symmetrical hydrogen bonds at the opposite ends of the class II antigen-binding groove (beta-His-81, beta-Asn-82 vs. alpha-His-68, alpha-Asn-69). In this study, we alter these peripheral hydrogen bonds and measure the apparent contribution of each to the kinetic stability of peptide* II complexes. Single conservative amino substitutions were made in the I-A(d) protein to eliminate participation as a hydrogen bonding residue, and the kinetic stability of a diverse set of peptides bound to the substituted I-A(d) proteins was measured. Although each hydrogen bond does contribute to peptide binding, our results point to the striking conclusion that those hydrogen bonds localized to the amino terminus of the peptide contribute profoundly and disproportionately to the stability of peptide interactions with I-A(d). We suggest that the peripheral hydrogen bonds at the amino terminus of the bound peptide that are conserved in all class II*peptide crystal structures solved thus far form a cooperative network that critically regulates peptide dissociation from the class II molecule." @default.
• W2136245027 created "2016-06-24" @default.
• W2136245027 creator A5007453136 @default.
• W2136245027 creator A5074802230 @default.
• W2136245027 creator A5082611786 @default.
• W2136245027 creator A5085553594 @default.
• W2136245027 date "2001-07-24" @default.
• W2136245027 modified "2023-09-23" @default.
• W2136245027 title "Energetic asymmetry among hydrogen bonds in MHC class II⋅peptide complexes" @default.
• W2136245027 cites W1533530009 @default.
• W2136245027 cites W1541629890 @default.
• W2136245027 cites W1975085335 @default.
• W2136245027 cites W1976459392 @default.
• W2136245027 cites W1990316350 @default.
• W2136245027 cites W1993219476 @default.
• W2136245027 cites W2003986211 @default.
• W2136245027 cites W2012507946 @default.
• W2136245027 cites W2015881562 @default.
• W2136245027 cites W2016779929 @default.
• W2136245027 cites W2018620812 @default.
• W2136245027 cites W2025476985 @default.
• W2136245027 cites W2026954941 @default.
• W2136245027 cites W2028663182 @default.
• W2136245027 cites W2043762183 @default.
• W2136245027 cites W2047233981 @default.
• W2136245027 cites W2058071227 @default.
• W2136245027 cites W2060913542 @default.
• W2136245027 cites W2069253284 @default.
• W2136245027 cites W2080956086 @default.
• W2136245027 cites W2083046120 @default.
• W2136245027 cites W2087106927 @default.
• W2136245027 cites W2090342749 @default.
• W2136245027 cites W2095352046 @default.
• W2136245027 cites W2102678059 @default.
• W2136245027 cites W2112804922 @default.
• W2136245027 cites W2114957284 @default.
• W2136245027 cites W2140050918 @default.
• W2136245027 cites W2144275420 @default.
• W2136245027 cites W2157121950 @default.
• W2136245027 cites W2166972035 @default.
• W2136245027 cites W2414529992 @default.
• W2136245027 doi "https://doi.org/10.1073/pnas.151131498" @default.
• W2136245027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/55403" @default.
• W2136245027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11470892" @default.
• W2136245027 hasPublicationYear "2001" @default.
• W2136245027 type Work @default.
• W2136245027 sameAs 2136245027 @default.
• W2136245027 citedByCount "44" @default.
• W2136245027 countsByYear W21362450272012 @default.
• W2136245027 countsByYear W21362450272013 @default.
• W2136245027 countsByYear W21362450272015 @default.
• W2136245027 countsByYear W21362450272016 @default.
• W2136245027 countsByYear W21362450272017 @default.
• W2136245027 countsByYear W21362450272018 @default.
• W2136245027 countsByYear W21362450272019 @default.
• W2136245027 countsByYear W21362450272020 @default.
• W2136245027 countsByYear W21362450272022 @default.
• W2136245027 countsByYear W21362450272023 @default.
• W2136245027 crossrefType "journal-article" @default.
• W2136245027 hasAuthorship W2136245027A5007453136 @default.
• W2136245027 hasAuthorship W2136245027A5074802230 @default.
• W2136245027 hasAuthorship W2136245027A5082611786 @default.
• W2136245027 hasAuthorship W2136245027A5085553594 @default.
• W2136245027 hasBestOaLocation W21362450272 @default.
• W2136245027 hasConcept C104317684 @default.
• W2136245027 hasConcept C112887158 @default.
• W2136245027 hasConcept C159547669 @default.
• W2136245027 hasConcept C167625842 @default.
• W2136245027 hasConcept C178790620 @default.
• W2136245027 hasConcept C185592680 @default.
• W2136245027 hasConcept C2779281246 @default.
• W2136245027 hasConcept C32909587 @default.
• W2136245027 hasConcept C515207424 @default.
• W2136245027 hasConcept C55493867 @default.
• W2136245027 hasConcept C71240020 @default.
• W2136245027 hasConcept C8010536 @default.
• W2136245027 hasConceptScore W2136245027C104317684 @default.
• W2136245027 hasConceptScore W2136245027C112887158 @default.
• W2136245027 hasConceptScore W2136245027C159547669 @default.
• W2136245027 hasConceptScore W2136245027C167625842 @default.
• W2136245027 hasConceptScore W2136245027C178790620 @default.
• W2136245027 hasConceptScore W2136245027C185592680 @default.
• W2136245027 hasConceptScore W2136245027C2779281246 @default.
• W2136245027 hasConceptScore W2136245027C32909587 @default.
• W2136245027 hasConceptScore W2136245027C515207424 @default.
• W2136245027 hasConceptScore W2136245027C55493867 @default.
• W2136245027 hasConceptScore W2136245027C71240020 @default.
• W2136245027 hasConceptScore W2136245027C8010536 @default.
• W2136245027 hasIssue "16" @default.
• W2136245027 hasLocation W21362450271 @default.
• W2136245027 hasLocation W21362450272 @default.
• W2136245027 hasLocation W21362450273 @default.
• W2136245027 hasLocation W21362450274 @default.
• W2136245027 hasOpenAccess W2136245027 @default.
• W2136245027 hasPrimaryLocation W21362450271 @default.
• W2136245027 hasRelatedWork W1977884460 @default.
• W2136245027 hasRelatedWork W1991674640 @default.
• W2136245027 hasRelatedWork W1996887642 @default.

• next