FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2136246382> ?p ?o ?g. }

• W2136246382 endingPage "157" @default.
• W2136246382 startingPage "151" @default.
• W2136246382 abstract "We examined which of the known properties of trifluoperazine, including calmodulin inhibition, are involved in its analgesic effect. Furthermore, we tried to find any possible interaction between opioidergic system and calmodulin inhibition-induced analgesia. Intrathecal trifluoperazine (1, 10, 100 microg) showed a biphasic effect in the formalin test; i.e., analgesia at relatively low doses (1, 10 microg) and hyperalgesia at a high dose (100 microg). No analgesic effects were observed after intrathecal injection of sulpiride (1, 10, 100 microg), atropine (0.1, 1, 10 microg), phentolamine (0.1, 1, 10 microg) and brompheniramine (0.1, 1, 10 microg). Meanwhile, intrathecal calmidazolium (10, 50, 250 microg) induced a dose-dependent analgesia. Histamine (1 microg), physostigmine (1 microg), bromocriptine (1 microg) and norepinephrine (1 microg) did not affect trifluoperazine-induced analgesia. Calcium (20 microg) attenuated the antinociceptive effect of trifluoperazine and inhibited the analgesic effect of calmidazolium. Finally, naloxone (2 mg/kg) decreased trifluoperazine-induced antinociception but did not have any effects on calmidazolium-induced analgesia. We concluded that calmodulin inhibition may be involved in the analgesia produced by trifluoperazine. With increasing doses of trifluoperazine, the algesic effect seems to overcome the analgesic effect. It is also suggested that the opioidergic system does not interact with calmodulin inhibition-induced analgesia even though this system has a possible role in trifluoperazine-induced analgesia." @default.
• W2136246382 created "2016-06-24" @default.
• W2136246382 creator A5001216578 @default.
• W2136246382 creator A5006555299 @default.
• W2136246382 creator A5020250038 @default.
• W2136246382 creator A5035850424 @default.
• W2136246382 creator A5074951815 @default.
• W2136246382 date "2002-01-01" @default.
• W2136246382 modified "2023-10-17" @default.
• W2136246382 title "Involvement of Calmodulin Inhibition in Analgesia Induced With Low Doses of Intrathecal Trifluoperazine" @default.
• W2136246382 cites W1834905825 @default.
• W2136246382 cites W1964941501 @default.
• W2136246382 cites W1983112432 @default.
• W2136246382 cites W1988602401 @default.
• W2136246382 cites W1992622931 @default.
• W2136246382 cites W1994067213 @default.
• W2136246382 cites W2001247139 @default.
• W2136246382 cites W2005100019 @default.
• W2136246382 cites W2006911376 @default.
• W2136246382 cites W2008287665 @default.
• W2136246382 cites W2009345240 @default.
• W2136246382 cites W2023134404 @default.
• W2136246382 cites W2031754222 @default.
• W2136246382 cites W2034603577 @default.
• W2136246382 cites W2036028099 @default.
• W2136246382 cites W2040725197 @default.
• W2136246382 cites W2041570682 @default.
• W2136246382 cites W2056141898 @default.
• W2136246382 cites W2064541423 @default.
• W2136246382 cites W2078852704 @default.
• W2136246382 cites W2079235930 @default.
• W2136246382 cites W2083121463 @default.
• W2136246382 cites W2087608819 @default.
• W2136246382 cites W2087991407 @default.
• W2136246382 cites W2090734244 @default.
• W2136246382 cites W2092770533 @default.
• W2136246382 cites W2141724365 @default.
• W2136246382 cites W2146958131 @default.
• W2136246382 cites W2153450015 @default.
• W2136246382 cites W2161764701 @default.
• W2136246382 cites W2253302896 @default.
• W2136246382 cites W2286774932 @default.
• W2136246382 cites W2417105792 @default.
• W2136246382 cites W39570287 @default.
• W2136246382 cites W52465857 @default.
• W2136246382 cites W2531247149 @default.
• W2136246382 doi "https://doi.org/10.1254/jjp.88.151" @default.
• W2136246382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11928715" @default.
• W2136246382 hasPublicationYear "2002" @default.
• W2136246382 type Work @default.
• W2136246382 sameAs 2136246382 @default.
• W2136246382 citedByCount "7" @default.
• W2136246382 countsByYear W21362463822012 @default.
• W2136246382 countsByYear W21362463822018 @default.
• W2136246382 crossrefType "journal-article" @default.
• W2136246382 hasAuthorship W2136246382A5001216578 @default.
• W2136246382 hasAuthorship W2136246382A5006555299 @default.
• W2136246382 hasAuthorship W2136246382A5020250038 @default.
• W2136246382 hasAuthorship W2136246382A5035850424 @default.
• W2136246382 hasAuthorship W2136246382A5074951815 @default.
• W2136246382 hasBestOaLocation W21362463821 @default.
• W2136246382 hasConcept C126322002 @default.
• W2136246382 hasConcept C134018914 @default.
• W2136246382 hasConcept C170493617 @default.
• W2136246382 hasConcept C185592680 @default.
• W2136246382 hasConcept C24998067 @default.
• W2136246382 hasConcept C2775864247 @default.
• W2136246382 hasConcept C2775891158 @default.
• W2136246382 hasConcept C2776885963 @default.
• W2136246382 hasConcept C2778206117 @default.
• W2136246382 hasConcept C2778750930 @default.
• W2136246382 hasConcept C2779004600 @default.
• W2136246382 hasConcept C2780253649 @default.
• W2136246382 hasConcept C2780806966 @default.
• W2136246382 hasConcept C2780820201 @default.
• W2136246382 hasConcept C29688787 @default.
• W2136246382 hasConcept C519063684 @default.
• W2136246382 hasConcept C55493867 @default.
• W2136246382 hasConcept C71924100 @default.
• W2136246382 hasConcept C98274493 @default.
• W2136246382 hasConceptScore W2136246382C126322002 @default.
• W2136246382 hasConceptScore W2136246382C134018914 @default.
• W2136246382 hasConceptScore W2136246382C170493617 @default.
• W2136246382 hasConceptScore W2136246382C185592680 @default.
• W2136246382 hasConceptScore W2136246382C24998067 @default.
• W2136246382 hasConceptScore W2136246382C2775864247 @default.
• W2136246382 hasConceptScore W2136246382C2775891158 @default.
• W2136246382 hasConceptScore W2136246382C2776885963 @default.
• W2136246382 hasConceptScore W2136246382C2778206117 @default.
• W2136246382 hasConceptScore W2136246382C2778750930 @default.
• W2136246382 hasConceptScore W2136246382C2779004600 @default.
• W2136246382 hasConceptScore W2136246382C2780253649 @default.
• W2136246382 hasConceptScore W2136246382C2780806966 @default.
• W2136246382 hasConceptScore W2136246382C2780820201 @default.
• W2136246382 hasConceptScore W2136246382C29688787 @default.
• W2136246382 hasConceptScore W2136246382C519063684 @default.
• W2136246382 hasConceptScore W2136246382C55493867 @default.
• W2136246382 hasConceptScore W2136246382C71924100 @default.

• next