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- W2136254458 endingPage "2180" @default.
- W2136254458 startingPage "2173" @default.
- W2136254458 abstract "ABSTRACT Human herpesviruses (HHVs) are ubiquitous pathogens that intermittently reactivate from latency. Transmission is believed to be facilitated by their frequent appearance in saliva. This study sought to understand the factors that influence the appearance of these viruses in saliva by examining the prevalence, pattern, and quantity of all eight HHVs in saliva of immunocompetent adults with a history of recurrent oral herpes simplex virus (HSV) infections following dental treatment and antiviral therapy. Valacyclovir or matched placebo was given (2 g twice on the day of treatment and 1 g twice the following day) to 125 patients in a randomized, double-blind controlled trial. Saliva, collected on the day of dental treatment and 3 and 7 days later, was analyzed using real-time quantitative PCR. At all visits, HHVs coinfected saliva. Over the course of the week, the DNAs of HHV-6 and HHV-7 were detected significantly more often (97% to 99% of patients) than Epstein-Barr virus (EBV; 64.8%), HSV-1 (13.0%), HHV-8 (3.2%), cytomegalovirus (2.4%), HSV-2 (0%), and varicella-zoster virus (0%), irrespective of drug treatment ( P < 0.002). Mean genome copy numbers were highest for HSV-1 and HHV-6. Dental treatment did not influence asymptomatic viral shedding patterns. However, valacyclovir treatment resulted in significantly fewer patients shedding EBV at both postoperative visits compared with placebo ( P < 0.008). These results suggest that HHVs are simultaneously present in the saliva of healthy adults at levels that could facilitate transmission, and valacyclovir therapy decreases the prevalence of EBV in saliva but has little effect on HHV-6 and HHV-7." @default.
- W2136254458 created "2016-06-24" @default.
- W2136254458 creator A5029451122 @default.
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- W2136254458 creator A5081688346 @default.
- W2136254458 creator A5082938315 @default.
- W2136254458 creator A5087047490 @default.
- W2136254458 date "2005-05-01" @default.
- W2136254458 modified "2023-09-25" @default.
- W2136254458 title "Effect of Prophylactic Valacyclovir on the Presence of Human Herpesvirus DNA in Saliva of Healthy Individuals after Dental Treatment" @default.
- W2136254458 cites W119634233 @default.
- W2136254458 cites W142417936 @default.
- W2136254458 cites W144745876 @default.
- W2136254458 cites W1512774751 @default.
- W2136254458 cites W1589492593 @default.
- W2136254458 cites W1672521926 @default.
- W2136254458 cites W168248326 @default.
- W2136254458 cites W1824022572 @default.
- W2136254458 cites W1966893320 @default.
- W2136254458 cites W1973062635 @default.
- W2136254458 cites W1974685586 @default.
- W2136254458 cites W1975679036 @default.
- W2136254458 cites W1976747381 @default.
- W2136254458 cites W1976888433 @default.
- W2136254458 cites W1977940165 @default.
- W2136254458 cites W1979257334 @default.
- W2136254458 cites W1980832209 @default.
- W2136254458 cites W1986062079 @default.
- W2136254458 cites W1987717229 @default.
- W2136254458 cites W1989432488 @default.
- W2136254458 cites W2002627178 @default.
- W2136254458 cites W2006724069 @default.
- W2136254458 cites W2012161992 @default.
- W2136254458 cites W2013586951 @default.
- W2136254458 cites W2013643465 @default.
- W2136254458 cites W2019107361 @default.
- W2136254458 cites W2023239238 @default.
- W2136254458 cites W2023352897 @default.
- W2136254458 cites W2028016841 @default.
- W2136254458 cites W2031522803 @default.
- W2136254458 cites W2032507422 @default.
- W2136254458 cites W2037840492 @default.
- W2136254458 cites W2046455634 @default.
- W2136254458 cites W2046566170 @default.
- W2136254458 cites W2049021121 @default.
- W2136254458 cites W2054577599 @default.
- W2136254458 cites W2055963840 @default.
- W2136254458 cites W2057440581 @default.
- W2136254458 cites W2060234765 @default.
- W2136254458 cites W2063393908 @default.
- W2136254458 cites W2069227770 @default.
- W2136254458 cites W2084536063 @default.
- W2136254458 cites W2087477023 @default.
- W2136254458 cites W2091146466 @default.
- W2136254458 cites W2092253144 @default.
- W2136254458 cites W2093573397 @default.
- W2136254458 cites W2097896008 @default.
- W2136254458 cites W2103533552 @default.
- W2136254458 cites W2105578914 @default.
- W2136254458 cites W2107943733 @default.
- W2136254458 cites W2108230984 @default.
- W2136254458 cites W2108824537 @default.
- W2136254458 cites W2114210493 @default.
- W2136254458 cites W2114689506 @default.
- W2136254458 cites W2116647385 @default.
- W2136254458 cites W2123446386 @default.
- W2136254458 cites W2123509633 @default.
- W2136254458 cites W2125072799 @default.
- W2136254458 cites W2125571151 @default.
- W2136254458 cites W2127950322 @default.
- W2136254458 cites W2128254664 @default.
- W2136254458 cites W2132447826 @default.
- W2136254458 cites W2133241248 @default.
- W2136254458 cites W2140671300 @default.
- W2136254458 cites W2146812842 @default.
- W2136254458 cites W2147776714 @default.
- W2136254458 cites W2148172598 @default.
- W2136254458 cites W2148417660 @default.
- W2136254458 cites W2155969241 @default.
- W2136254458 cites W2156604913 @default.
- W2136254458 cites W2160667223 @default.
- W2136254458 cites W2161298427 @default.
- W2136254458 cites W2164606228 @default.
- W2136254458 cites W2165312158 @default.
- W2136254458 cites W2166421599 @default.
- W2136254458 cites W2166534318 @default.
- W2136254458 cites W2167127147 @default.
- W2136254458 cites W2167517233 @default.
- W2136254458 cites W2168801583 @default.
- W2136254458 cites W2267660154 @default.
- W2136254458 cites W2316483500 @default.
- W2136254458 cites W2323865642 @default.
- W2136254458 cites W2330686085 @default.
- W2136254458 cites W2397043114 @default.
- W2136254458 cites W2412896983 @default.
- W2136254458 cites W24382251 @default.
- W2136254458 cites W2967025170 @default.
- W2136254458 cites W31152949 @default.